{"id":"https://openalex.org/W6987313240","doi":null,"title":"Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal Health","display_name":"Simulated Space Radiation and Weightlessness: Vascular-Bone Coupling Mechanisms to Preserve Skeletal Health","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W6987313240"},"language":"en","primary_location":{"id":"pmh:oai:casi.ntrs.nasa.gov:20120011349","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2060/20120011349","pdf_url":null,"source":{"id":"https://openalex.org/S4377196257","display_name":"NASA STI Repository (National Aeronautics and Space Administration)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CASI","raw_type":"ARC-E-DAA-TN4471"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Delp, M. D.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delp, M. D.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Limoli, C. L.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Limoli, C. L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Alwood, J. S.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alwood, J. S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105458980","display_name":"Alesha B. Castillo","orcid":"https://orcid.org/0000-0002-1371-7567","observed_orcids":["https://orcid.org/0000-0002-1371-7567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Castillo, A. B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062582492","display_name":"Ruth K. Globus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Globus, R. K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51039485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/microgravity","display_name":"microgravity","score":0.9380000233650208},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bone-vascularization","display_name":"bone vascularization","score":0.5130000114440918},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7630000114440918},{"id":"https://openalex.org/keywords/antioxidant-treatment","display_name":"antioxidant treatment","score":0.5630000233650208},{"id":"https://openalex.org/keywords/hindlimb-unloading","display_name":"hindlimb unloading","score":0.8270000219345093},{"id":"https://openalex.org/keywords/heavy-ion-irradiation","display_name":"heavy ion irradiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.7789999842643738},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.8140000104904175},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/fluid-shifts","display_name":"fluid shifts","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C37752432","wikidata":"https://www.wikidata.org/wiki/Q4299309","display_name":"Weightlessness","level":2,"score":0.8795999884605408},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6643000245094299},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.428600013256073},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.4004000127315521},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.3790999948978424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3643999993801117},{"id":"https://openalex.org/C2779925993","wikidata":"https://www.wikidata.org/wiki/Q336938","display_name":"Radiation exposure","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28780001401901245},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C125118446","wikidata":"https://www.wikidata.org/wiki/Q690200","display_name":"Radiobiology","level":3,"score":0.28029999136924744},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2800999879837036},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2703999876976013},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C2987978230","wikidata":"https://www.wikidata.org/wiki/Q5691173","display_name":"Space radiation","level":3,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:casi.ntrs.nasa.gov:20120011349","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2060/20120011349","pdf_url":null,"source":{"id":"https://openalex.org/S4377196257","display_name":"NASA STI Repository (National Aeronautics and Space Administration)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210124779","host_organization_name":"National Aeronautics and Space Administration","host_organization_lineage":["https://openalex.org/I4210124779"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"CASI","raw_type":"ARC-E-DAA-TN4471"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7065324894","https://openalex.org/W3172295637","https://openalex.org/W2789839262","https://openalex.org/W6987220853","https://openalex.org/W2303018668","https://openalex.org/W7016861931","https://openalex.org/W2748190508","https://openalex.org/W2587185047","https://openalex.org/W2143327145","https://openalex.org/W2740192234"],"abstract_inverted_index":{"Weightlessness":[0],"causes":[1],"a":[2,118],"cephalad":[3],"fluid":[4],"shift":[5],"and":[6,15,37,40,54,79,88,99,107,145,150,174,180,187,197,212,217,229,235],"reduction":[7],"in":[8,19,190],"mechanical":[9],"stimulation,":[10],"adversely":[11],"affecting":[12],"both":[13,105],"cortical":[14],"trabecular":[16],"bone":[17,29,112,127,143,186,194,215],"tissue":[18],"astronauts.":[20],"In":[21],"rodent":[22],"models":[23],"of":[24,28,73,162,177,193,238],"weightlessness,":[25],"the":[26,71,94,126,172,191,203,236],"onset":[27],"loss":[30,113,144,216],"correlates":[31],"with":[32,51,117,153],"reduced":[33,36,119],"skeletal":[34,188,228],"perfusion,":[35],"rarified":[38],"vasculature":[39,189,230],"lessened":[41],"vasodilation,":[42],"which":[43,206],"resembles":[44],"blood-bone":[45],"symbiotic":[46],"events":[47],"that":[48,114,136,151],"can":[49],"occur":[50],"fracture":[52],"repair":[53],"aging.":[55],"These":[56],"are":[57,167],"especially":[58],"serious":[59],"risks":[60],"for":[61,185],"long":[62],"term,":[63],"exploration":[64],"class":[65],"missions":[66],"when":[67],"astronauts":[68],"will":[69],"face":[70],"challenge":[72],"increased":[74],"exposure":[75,100,137],"to":[76,101,121,134,138,205,240],"space":[77,139,181,213,224],"radiation":[78,140,182,225],"abrupt":[80],"transitions":[81],"between":[82],"different":[83],"gravity":[84],"environments":[85],"upon":[86,148],"arrival":[87],"return.":[89],"Previously,":[90],"we":[91],"found":[92],"using":[93],"mouse":[95],"hindlimb":[96],"unloading":[97],"model":[98],"heavy":[102],"ion":[103],"radiation,":[104],"disuse":[106],"irradiation":[108],"cause":[109],"an":[110,207],"acute":[111],"was":[115],"associated":[116],"capacity":[120],"produce":[122],"bone-forming":[123],"osteoblasts":[124],"from":[125,232],"marrow.":[128],"Together,":[129],"these":[130,157],"findings":[131],"led":[132],"us":[133],"hypothesize":[135],"exacerbates":[141],"weightlessness-induced":[142],"impairs":[146],"recovery":[147,231],"return,":[149],"treatment":[152],"anti-oxidants":[154,239],"may":[155],"mitigate":[156],"effects.":[158],"The":[159],"specific":[160],"aims":[161],"this":[163],"recently":[164],"awarded":[165],"grant":[166],"to:":[168],"AIM":[169,200,220],"1":[170],"Determine":[171,202,222],"functional":[173],"structural":[175],"consequences":[176],"prolonged":[178,233],"weightlessness":[179,211,234],"(simulated":[183],"spaceflight)":[184],"context":[192],"cell":[195],"function":[196],"oxidative":[198],"stress.":[199],"2":[201],"extent":[204],"anti-oxidant":[208],"protects":[209],"against":[210],"radiation-induced":[214],"vascular":[218],"dysfunction.":[219],"3":[221],"how":[223],"influences":[226],"later":[227],"potential":[237],"preserve":[241],"adaptive":[242],"remodeling.":[243]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}