{"id":"https://openalex.org/W6987183244","doi":null,"title":"Separation of Modified Biomolecules With Synthetic Receptors in Capillary Electrophoresis","display_name":"Separation of Modified Biomolecules With Synthetic Receptors in Capillary Electrophoresis","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W6987183244"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt7403082s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7403082s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lee, Jiwon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lee, Jiwon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.11400000005960464,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.04690000042319298,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lysine-methylation","display_name":"lysine methylation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/synthetic-receptors","display_name":"synthetic receptors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/calixarenes","display_name":"calixarenes","score":0.875},{"id":"https://openalex.org/keywords/cucurbituril","display_name":"cucurbituril","score":0.9990000128746033},{"id":"https://openalex.org/keywords/demethylation","display_name":"demethylation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/host-guest-recognition","display_name":"host-guest recognition","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7506999969482422},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.6948999762535095},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6288999915122986},{"id":"https://openalex.org/C2900643","wikidata":"https://www.wikidata.org/wiki/Q747468","display_name":"Capillary electrophoresis","level":2,"score":0.5976999998092651},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5392000079154968},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45840001106262207},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4462999999523163},{"id":"https://openalex.org/C3018256011","wikidata":"https://www.wikidata.org/wiki/Q898987","display_name":"Separation method","level":2,"score":0.4307999908924103},{"id":"https://openalex.org/C40250595","wikidata":"https://www.wikidata.org/wiki/Q185098","display_name":"Electrophoresis","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.3716999888420105},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.33059999346733093},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.2809999883174896},{"id":"https://openalex.org/C162602672","wikidata":"https://www.wikidata.org/wiki/Q2695129","display_name":"Molecularly imprinted polymer","level":4,"score":0.2777000069618225},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2750999927520752},{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.2667999863624573},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C37601429","wikidata":"https://www.wikidata.org/wiki/Q4688978","display_name":"Affinity electrophoresis","level":4,"score":0.2581999897956848},{"id":"https://openalex.org/C2988629283","wikidata":"https://www.wikidata.org/wiki/Q44337","display_name":"Complex matrix","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2515000104904175}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt7403082s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7403082s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7403082s","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7403082s","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2780484840","https://openalex.org/W3009018622","https://openalex.org/W3003802685","https://openalex.org/W2103023204","https://openalex.org/W2583750572","https://openalex.org/W4390810992","https://openalex.org/W2794239972","https://openalex.org/W2068214485","https://openalex.org/W2562582209","https://openalex.org/W2411156563"],"abstract_inverted_index":{"Post-translational":[0],"modifications":[1,20],"(PTMs)":[2],"on":[3,16],"histone":[4,17,87,297],"proteins":[5,318],"affect":[6],"many":[7],"essential":[8],"biological":[9,54],"processes.":[10],"With":[11],"the":[12,46,84,144,208,231,238,268,301],"abundance":[13],"of":[14,40,76,86,146,235,241,245,270,289,303,313],"PTMs":[15,320],"proteins,":[18],"these":[19,41,199],"can":[21,51,195,203,299],"collectively":[22],"work":[23],"together":[24],"to":[25,58,94,108,136,219,258,316],"alter":[26,143],"chromatin":[27],"structure":[28],"and":[29,38,56,74,79,102,112,124,158,182,227,237,247,278],"impact":[30,300],"gene":[31],"expression":[32],"in":[33,106,149,156,167,207,293],"this":[34,212,266],"complex":[35],"system.":[36],"Detection":[37],"understanding":[39],"PTMs,":[42],"as":[43,45,98,321],"well":[44],"enzymes":[47],"that":[48,67,132,170,194],"mediate":[49],"them,":[50],"elucidate":[52],"their":[53],"outcomes":[55],"connection":[57],"pathogenesis.":[59],"Mass":[60],"spectrometry":[61],"(MS)":[62],"is":[63,68,188,311],"a":[64,217,290,295],"powerful":[65],"tool":[66],"most":[69],"often":[70],"used":[71],"for":[72,130,173,223,287,306],"identification":[73],"characterization":[75],"modification":[77,298],"patterns,":[78],"it":[80,151],"has":[81,162,282],"greatly":[82],"expanded":[83],"library":[85],"modifications.":[88],"However,":[89],"MS":[90],"does":[91,141],"require":[92],"coupling":[93],"separation":[95,126,192,209,244],"techniques,":[96],"such":[97],"reversed-phase":[99],"liquid":[100],"chromatography":[101],"hydrophilic":[103],"interaction":[104],"chromatography,":[105],"order":[107],"reduce":[109],"sample":[110],"complexity":[111],"improve":[113],"analysis.":[114],"While":[115],"chromatographic":[116],"techniques":[117],"have":[118,171],"been":[119,163],"widely":[120],"used,":[121],"multiple":[122],"columns":[123],"long":[125],"times":[127],"are":[128,133],"required":[129],"peptides":[131,249],"more":[134],"challenging":[135],"separate.":[137],"For":[138],"instance,":[139],"methylation":[140,263],"not":[142],"charge":[145],"lysine":[147,174,262],"residues;":[148],"addition,":[150],"introduces":[152],"only":[153],"subtle":[154],"changes":[155],"size":[157],"hydrophobicity.":[159],"Recently,":[160],"there":[161,310],"an":[164,189,304],"increasing":[165],"interest":[166],"synthetic":[168,200],"receptors":[169,177],"affinity":[172],"methylation.":[175],"Such":[176],"include":[178],"water-soluble":[179],"calixarenes,":[180],"cucurbiturils,":[181],"deep":[183],"cavitands.":[184],"Capillary":[185],"electrophoresis":[186],"(CE)":[187],"extremely":[190],"suitable":[191],"method":[193,218,255],"be":[196,204],"combined":[197],"with":[198,319],"receptors,":[201],"which":[202,294],"easily":[205],"included":[206],"buffer.":[210],"In":[211],"work,":[213],"we":[214],"first":[215],"developed":[216],"induce":[220],"mobility":[221],"shifts":[222],"methylated":[224],"small":[225],"guests":[226],"peptides.":[228],"After":[229],"combining":[230],"high":[232],"resolving":[233],"power":[234],"CE":[236,254,315],"selective":[239],"recognition":[240],"host":[242],"molecules,":[243],"modified":[246],"unmodified":[248],"was":[250,256],"achieved.":[251],"This":[252,280],"host-assisted":[253,314],"able":[257],"discriminate":[259],"between":[260],"different":[261],"levels;":[264],"essentially,":[265],"enabled":[267],"monitoring":[269],"various":[271],"PTM":[272],"enzyme":[273,305],"reactions,":[274],"including":[275],"demethylation,":[276],"methylation,":[277],"phosphorylation.":[279],"technique":[281],"also":[283],"demonstrated":[284],"its":[285],"capability":[286],"analysis":[288],"crosstalk":[291],"event":[292],"pre-existing":[296],"activity":[302],"another":[307],"PTM.":[308],"Furthermore,":[309],"potential":[312],"separate":[317],"well.":[322]},"counts_by_year":[],"updated_date":"2026-09-09T07:26:56.047234","created_date":"2025-10-10T00:00:00"}
