{"id":"https://openalex.org/W6987071752","doi":null,"title":"Roles of post-transcriptional modifications in Solanum lycopersicum","display_name":"Roles of post-transcriptional modifications in Solanum lycopersicum","publication_year":2022,"publication_date":"2022-08-03","ids":{"openalex":"https://openalex.org/W6987071752"},"language":"en","primary_location":{"id":"pmh:oai:eprints.nottingham.ac.uk:69238","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/69238/1/Cameron%20Grundy%20-%20Doctoral%20Thesis%20-%20Corrected%20.pdf","pdf_url":"https://eprints.nottingham.ac.uk/69238/1/Cameron%20Grundy%20-%20Doctoral%20Thesis%20-%20Corrected%20.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.nottingham.ac.uk/bitstreams/82eeee1c-ce77-47e6-a3b6-8429dc09e851/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Grundy, Cameron H S","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Grundy, Cameron H S","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/m6a-methylation","display_name":"m6A RNA methylation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/yth-domain-proteins","display_name":"YTH domain proteins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ythdf1","display_name":"YTHDF1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":1.0},{"id":"https://openalex.org/keywords/ythdf3","display_name":"YTHDF3","score":1.0},{"id":"https://openalex.org/keywords/tomato","display_name":"tomato","score":0.9860000014305115},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/salt-stress","display_name":"salt stress","score":0.7870000004768372},{"id":"https://openalex.org/keywords/consensus-sequence","display_name":"consensus sequence","score":0.5},{"id":"https://openalex.org/keywords/protein-redundancy","display_name":"protein redundancy","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C2781083041","wikidata":"https://www.wikidata.org/wiki/Q146555","display_name":"Solanum","level":2,"score":0.7612000107765198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7145000100135803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5123999714851379},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47699999809265137},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4742000102996826},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.47099998593330383},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.45159998536109924},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4275999963283539},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4219000041484833},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40869998931884766},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4058000147342682},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33719998598098755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3314000070095062},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C2778239642","wikidata":"https://www.wikidata.org/wiki/Q3045481","display_name":"Plant development","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C2985179745","wikidata":"https://www.wikidata.org/wiki/Q131449","display_name":"Plant species","level":2,"score":0.2946999967098236},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C2779315201","wikidata":"https://www.wikidata.org/wiki/Q414601","display_name":"Sequence homology","level":4,"score":0.2824999988079071},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.28220000863075256},{"id":"https://openalex.org/C3019009989","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Plant protein","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.26660001277923584},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.nottingham.ac.uk:69238","doi":null,"is_oa":false,"landing_page_url":"https://eprints.nottingham.ac.uk/69238/1/Cameron%20Grundy%20-%20Doctoral%20Thesis%20-%20Corrected%20.pdf","pdf_url":"https://eprints.nottingham.ac.uk/69238/1/Cameron%20Grundy%20-%20Doctoral%20Thesis%20-%20Corrected%20.pdf","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Thesis (University of Nottingham only)"},{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/59510","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/59510","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/82eeee1c-ce77-47e6-a3b6-8429dc09e851/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"}],"best_oa_location":{"id":"pmh:oai:repository.nottingham.ac.uk:123456789/59510","doi":null,"is_oa":true,"landing_page_url":"https://repository.nottingham.ac.uk/handle/123456789/59510","pdf_url":"https://repository.nottingham.ac.uk/bitstreams/82eeee1c-ce77-47e6-a3b6-8429dc09e851/download","source":{"id":"https://openalex.org/S4306402014","display_name":"Nottingham ePrints (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"ethesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.5666999816894531,"display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6987071752.pdf","grobid_xml":"https://content.openalex.org/works/W6987071752.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W776567260","https://openalex.org/W1734992670","https://openalex.org/W1933156045","https://openalex.org/W1941339056","https://openalex.org/W1970893992","https://openalex.org/W1970950317","https://openalex.org/W1972895159","https://openalex.org/W1977233304","https://openalex.org/W1978581274","https://openalex.org/W1981629946","https://openalex.org/W1982749428","https://openalex.org/W1986405290","https://openalex.org/W1986427733","https://openalex.org/W1987438700","https://openalex.org/W1987777159","https://openalex.org/W1987981719","https://openalex.org/W1988226525","https://openalex.org/W1989967763","https://openalex.org/W1990379499","https://openalex.org/W1991807334","https://openalex.org/W1992131459","https://openalex.org/W1992672580","https://openalex.org/W1996831533","https://openalex.org/W1996877837","https://openalex.org/W1997535872","https://openalex.org/W1998201734","https://openalex.org/W1999348612","https://openalex.org/W2000126667","https://openalex.org/W2001334836","https://openalex.org/W2003019599","https://openalex.org/W2003818671","https://openalex.org/W2005054126","https://openalex.org/W2006322387","https://openalex.org/W2007429249","https://openalex.org/W2008273587","https://openalex.org/W2009308529","https://openalex.org/W2009329319","https://openalex.org/W2011131953","https://openalex.org/W2016135634","https://openalex.org/W2016667239","https://openalex.org/W2018608365","https://openalex.org/W2019028857","https://openalex.org/W2021767455","https://openalex.org/W2022770379","https://openalex.org/W2025727763","https://openalex.org/W2029439198","https://openalex.org/W2035905956","https://openalex.org/W2040811909","https://openalex.org/W2044648543","https://openalex.org/W2045435533","https://openalex.org/W2050791777","https://openalex.org/W2050843600","https://openalex.org/W2051786026","https://openalex.org/W2052494348","https://openalex.org/W2053820259","https://openalex.org/W2055214702","https://openalex.org/W2055524446","https://openalex.org/W2059892207","https://openalex.org/W2062814567","https://openalex.org/W2062821957","https://openalex.org/W2064128480","https://openalex.org/W2064210252","https://openalex.org/W2065847836","https://openalex.org/W2066180422","https://openalex.org/W2067515559","https://openalex.org/W2071930821","https://openalex.org/W2073029061","https://openalex.org/W2078964320","https://openalex.org/W2082559221","https://openalex.org/W2083459777","https://openalex.org/W2084622414","https://openalex.org/W2085278634","https://openalex.org/W2087101377","https://openalex.org/W2088873069","https://openalex.org/W2090217746","https://openalex.org/W2091310902","https://openalex.org/W2091931541","https://openalex.org/W2093864708","https://openalex.org/W2101222632","https://openalex.org/W2101555571","https://openalex.org/W2101636211","https://openalex.org/W2102872651","https://openalex.org/W2102919823","https://openalex.org/W2104062741","https://openalex.org/W2105551327","https://openalex.org/W2107624922","https://openalex.org/W2108130533","https://openalex.org/W2115495500","https://openalex.org/W2117849671","https://openalex.org/W2119895133","https://openalex.org/W2120156669","https://openalex.org/W2127087804","https://openalex.org/W2128415323","https://openalex.org/W2132315340","https://openalex.org/W2132926880","https://openalex.org/W2133449910","https://openalex.org/W2134530067","https://openalex.org/W2137318078","https://openalex.org/W2138310356","https://openalex.org/W2143350291","https://openalex.org/W2145145979","https://openalex.org/W2145768975","https://openalex.org/W2147372875","https://openalex.org/W2148624148","https://openalex.org/W2151562469","https://openalex.org/W2153866367","https://openalex.org/W2155254243","https://openalex.org/W2155804510","https://openalex.org/W2161890613","https://openalex.org/W2163741321","https://openalex.org/W2163820831","https://openalex.org/W2164852392","https://openalex.org/W2165547003","https://openalex.org/W2168961527","https://openalex.org/W2169108775","https://openalex.org/W2180502603","https://openalex.org/W2210597779","https://openalex.org/W2213040759","https://openalex.org/W2269054226","https://openalex.org/W2271995006","https://openalex.org/W2277180634","https://openalex.org/W2299801542","https://openalex.org/W2308896320","https://openalex.org/W2314476006","https://openalex.org/W2327072409","https://openalex.org/W2336857745","https://openalex.org/W2342878844","https://openalex.org/W2403990263","https://openalex.org/W2442161751","https://openalex.org/W2466739815","https://openalex.org/W2489507000","https://openalex.org/W2503596412","https://openalex.org/W2507685096","https://openalex.org/W2509465044","https://openalex.org/W2516597552","https://openalex.org/W2520925527","https://openalex.org/W2525507785","https://openalex.org/W2532091902","https://openalex.org/W2538543247","https://openalex.org/W2559344646","https://openalex.org/W2562211106","https://openalex.org/W2600626962","https://openalex.org/W2602513088","https://openalex.org/W2613267149","https://openalex.org/W2616124103","https://openalex.org/W2626278962","https://openalex.org/W2627064270","https://openalex.org/W2632544498","https://openalex.org/W2726900405","https://openalex.org/W2744875888","https://openalex.org/W2750194183","https://openalex.org/W2751621434","https://openalex.org/W2754659296","https://openalex.org/W2754764090","https://openalex.org/W2761042033","https://openalex.org/W2762814002","https://openalex.org/W2764301500","https://openalex.org/W2765639695","https://openalex.org/W2769707765","https://openalex.org/W2769807951","https://openalex.org/W2770747479","https://openalex.org/W2776310795","https://openalex.org/W2780167957","https://openalex.org/W2782731154","https://openalex.org/W2786133340","https://openalex.org/W2790194840","https://openalex.org/W2791349417","https://openalex.org/W2795649819","https://openalex.org/W2796894265","https://openalex.org/W2800770690","https://openalex.org/W2803510059","https://openalex.org/W2810207915","https://openalex.org/W2881215346","https://openalex.org/W2884715962","https://openalex.org/W2884859505","https://openalex.org/W2886533440","https://openalex.org/W2891167139","https://openalex.org/W2891713480","https://openalex.org/W2892968638","https://openalex.org/W2899065760","https://openalex.org/W2899339826","https://openalex.org/W2901016862","https://openalex.org/W2901594129","https://openalex.org/W2903485910","https://openalex.org/W2909507412","https://openalex.org/W2909551222","https://openalex.org/W2912768590","https://openalex.org/W2913752156","https://openalex.org/W2915489297","https://openalex.org/W2947725313","https://openalex.org/W2962381110","https://openalex.org/W2966866763","https://openalex.org/W2967881004","https://openalex.org/W2969897014","https://openalex.org/W2972933339","https://openalex.org/W2979684814","https://openalex.org/W2989644512","https://openalex.org/W2994139222","https://openalex.org/W2999689892","https://openalex.org/W3025397233","https://openalex.org/W3026751717","https://openalex.org/W3040615014","https://openalex.org/W3042541158","https://openalex.org/W3048545728","https://openalex.org/W3119069404","https://openalex.org/W3123434787","https://openalex.org/W4206028215","https://openalex.org/W4214864012","https://openalex.org/W7096644567"],"related_works":["https://openalex.org/W3165466348","https://openalex.org/W4403973866","https://openalex.org/W4387638717","https://openalex.org/W4310704955","https://openalex.org/W4293206827","https://openalex.org/W4399173028","https://openalex.org/W7056184461","https://openalex.org/W7021081662","https://openalex.org/W2795649819","https://openalex.org/W3045194704"],"abstract_inverted_index":{"Methylation":[0],"at":[1],"the":[2,12,100,180],"N6":[3],"position":[4],"of":[5,36,99,103,194,234],"internal":[6],"adenosines":[7],"(m6A)":[8],"is":[9,39,69,83],"known":[10,84],"as":[11],"most":[13],"prevalent":[14],"and":[15,32,74,137,161,218],"widespread":[16],"modification":[17],"in":[18,25,88,106,132,164,171,211,221,231],"mRNA.":[19],"In":[20,143],"plants,":[21],"m6A":[22,62,68,134],"has":[23,179],"roles":[24],"post-transcriptional":[26],"gene":[27],"control,":[28],"influencing":[29],"growth,":[30],"development":[31,73],"reproduction.":[33],"The":[34],"function":[35],"these":[37,235],"modifications":[38],"often":[40],"mediated":[41],"by":[42],"RNA":[43],"binding":[44],"proteins":[45,87,105],"containing":[46],"a":[47,55,169,226],"YT521-B":[48],"homology":[49],"(YTH)":[50],"domain.":[51],"These":[52],"domains":[53],"contain":[54],"hydrophobic":[56],"pocket":[57],"that":[58,67,94,110,154,203],"can":[59],"directly":[60],"accommodate":[61],"residues.":[63],"Despite":[64],"studies":[65,76],"demonstrating":[66],"crucial":[70],"for":[71,215,228],"plant":[72,135],"multiple":[75],"on":[77],"mammalian":[78],"YTH":[79,86,104],"proteins,":[80],"very":[81],"little":[82],"about":[85],"plants.":[89],"Here,":[90],"we":[91,145,167],"have":[92,97,146,158],"identified":[93,131],"Solanum":[95,119],"lycopersicum":[96],"some":[98],"lowest":[101],"number":[102],"Plantae.":[107],"We":[108],"show":[109,213],"plants":[111],"lacking":[112],"YTHDF1,":[113],"YTHDF2,":[114],"YTHDF3":[115],"or":[116],"YTHDF4":[117],"from":[118],"lycopersicum,":[120],"exhibit":[121],"vegetative":[122],"growth":[123],"defects,":[124],"including":[125],"phenotypes":[126],"which":[127,152,178],"overlap":[128],"with":[129],"those":[130],"low":[133],"lines":[136],"respond":[138],"differently":[139],"to":[140,182,185,190,201],"salt":[141],"stress.":[142],"addition,":[144],"produced":[147],"several":[148],"YTHDF":[149,156,209],"double":[150],"mutants,":[151],"demonstrate":[153,168],"each":[155,208],"protein":[157,175,210],"both":[159,216],"redundant":[160],"specific":[162],"functions":[163],"vivo.":[165],"Finally,":[166],"novel":[170],"vitro":[172],"randomised":[173],"RNA-binding":[174],"selection":[176],"strategy,":[177],"potential":[181],"be":[183],"used":[184],"identify":[186,202],"key":[187],"consensus":[188],"sequences":[189,220],"further":[191],"our":[192,232],"understanding":[193,233],"complex":[195,236],"processes.":[196],"This":[197,223],"strategy":[198],"allowed":[199],"us":[200],"just":[204],"like":[205],"their":[206],"phenotypes,":[207],"tomato":[212],"affinity":[214],"unique":[217],"overlapping":[219],"vitro.":[222],"work":[224],"provides":[225],"platform":[227],"future":[229],"advances":[230],"proteins.":[237]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}