{"id":"https://openalex.org/W6987050856","doi":null,"title":"Role of Membrane Asymmetry in Nanoparticle-Erythrocyte Interactions","display_name":"Role of Membrane Asymmetry in Nanoparticle-Erythrocyte Interactions","publication_year":2020,"publication_date":"2020-09-17","ids":{"openalex":"https://openalex.org/W6987050856"},"language":"en","primary_location":{"id":"pmh:oai:etd.ohiolink.edu:ohiou1592343805622053","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039299788","display_name":"Parnian Bigdelou","orcid":"https://orcid.org/0000-0002-1841-7571","observed_orcids":["https://orcid.org/0000-0002-1841-7571"]},"institutions":[{"id":"https://openalex.org/I4210106879","display_name":"Ohio University","ror":"https://ror.org/01jr3y717","country_code":"US","type":"education","lineage":["https://openalex.org/I4210106879"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bigdelou, Parnian","raw_affiliation_strings":["Ohio University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio University","institution_ids":["https://openalex.org/I4210106879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039299788"],"corresponding_institution_ids":["https://openalex.org/I4210106879"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-asymmetry","display_name":"membrane asymmetry","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.7630000114440918},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/eryptosis","display_name":"eryptosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/silica-nanoparticles","display_name":"silica nanoparticles","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nanoparticle-membrane-interactions","display_name":"nanoparticle-membrane interactions","score":0.7570000290870667},{"id":"https://openalex.org/keywords/lipid-vesicles","display_name":"lipid vesicles","score":0.7730000019073486},{"id":"https://openalex.org/keywords/cell-deformation","display_name":"cell deformation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/calcium-ionophore","display_name":"calcium ionophore","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.8029999732971191},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7907000184059143},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.723800003528595},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.5975000262260437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5763999819755554},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5672000050544739},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.5116000175476074},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.5073999762535095},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.5023999810218811},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.4731999933719635},{"id":"https://openalex.org/C38976095","wikidata":"https://www.wikidata.org/wiki/Q752641","display_name":"Asymmetry","level":2,"score":0.4359999895095825},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C2776659728","wikidata":"https://www.wikidata.org/wiki/Q887004","display_name":"Leaflet (botany)","level":2,"score":0.40450000762939453},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.3716999888420105},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3578000068664551},{"id":"https://openalex.org/C560191","wikidata":"https://www.wikidata.org/wiki/Q417736","display_name":"Peripheral membrane protein","level":5,"score":0.33820000290870667},{"id":"https://openalex.org/C2994365204","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane integrity","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.31940001249313354},{"id":"https://openalex.org/C2780727160","wikidata":"https://www.wikidata.org/wiki/Q1500907","display_name":"Membrane structure","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C96347405","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biophysics","level":4,"score":0.2849999964237213},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26179999113082886},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C3018040386","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Lipid vesicle","level":4,"score":0.25519999861717224}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:etd.ohiolink.edu:ohiou1592343805622053","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:etd.ohiolink.edu:ohiou1592343805622053","doi":null,"is_oa":true,"landing_page_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","pdf_url":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","source":{"id":"https://openalex.org/S4377196344","display_name":"OhioLink ETD Center (Ohio Library and Information Network)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210155183","host_organization_name":"Ohio Library and Information Network","host_organization_lineage":["https://openalex.org/I4210155183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1592343805622053","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6987050856.pdf","grobid_xml":"https://content.openalex.org/works/W6987050856.grobid-xml"},"referenced_works_count":98,"referenced_works":["https://openalex.org/W583189843","https://openalex.org/W838565612","https://openalex.org/W1160326939","https://openalex.org/W1909416876","https://openalex.org/W1965352829","https://openalex.org/W1967558059","https://openalex.org/W1968188734","https://openalex.org/W1968412972","https://openalex.org/W1968527449","https://openalex.org/W1971428641","https://openalex.org/W1972050205","https://openalex.org/W1977986845","https://openalex.org/W1984765893","https://openalex.org/W1986231174","https://openalex.org/W1997588014","https://openalex.org/W1999137929","https://openalex.org/W2002528172","https://openalex.org/W2005956428","https://openalex.org/W2011206285","https://openalex.org/W2015709186","https://openalex.org/W2016530312","https://openalex.org/W2019471670","https://openalex.org/W2020845872","https://openalex.org/W2021680015","https://openalex.org/W2022066534","https://openalex.org/W2025810776","https://openalex.org/W2034555772","https://openalex.org/W2036134210","https://openalex.org/W2038864652","https://openalex.org/W2042710862","https://openalex.org/W2045484171","https://openalex.org/W2048056641","https://openalex.org/W2055182511","https://openalex.org/W2057256078","https://openalex.org/W2058559717","https://openalex.org/W2066395245","https://openalex.org/W2067121397","https://openalex.org/W2067273125","https://openalex.org/W2068728879","https://openalex.org/W2069739211","https://openalex.org/W2071436231","https://openalex.org/W2078278984","https://openalex.org/W2085820120","https://openalex.org/W2088565781","https://openalex.org/W2088972036","https://openalex.org/W2089697004","https://openalex.org/W2091392394","https://openalex.org/W2094348762","https://openalex.org/W2094990470","https://openalex.org/W2096474273","https://openalex.org/W2096776708","https://openalex.org/W2097098920","https://openalex.org/W2111423624","https://openalex.org/W2117416272","https://openalex.org/W2122881251","https://openalex.org/W2127186004","https://openalex.org/W2129335264","https://openalex.org/W2131523916","https://openalex.org/W2131785128","https://openalex.org/W2134158036","https://openalex.org/W2137374477","https://openalex.org/W2139387137","https://openalex.org/W2139820378","https://openalex.org/W2144546631","https://openalex.org/W2148045277","https://openalex.org/W2149952617","https://openalex.org/W2153321597","https://openalex.org/W2156406953","https://openalex.org/W2156672048","https://openalex.org/W2157187673","https://openalex.org/W2161055212","https://openalex.org/W2164278547","https://openalex.org/W2165294395","https://openalex.org/W2324198136","https://openalex.org/W2329169327","https://openalex.org/W2329308917","https://openalex.org/W2395642814","https://openalex.org/W2414933268","https://openalex.org/W2533516264","https://openalex.org/W2535718410","https://openalex.org/W2563263261","https://openalex.org/W2563561063","https://openalex.org/W2566965061","https://openalex.org/W2613837805","https://openalex.org/W2743467450","https://openalex.org/W2760049479","https://openalex.org/W2781697521","https://openalex.org/W2790188895","https://openalex.org/W2809886833","https://openalex.org/W2891006829","https://openalex.org/W2895943463","https://openalex.org/W2920672763","https://openalex.org/W2922494586","https://openalex.org/W2995646607","https://openalex.org/W3002103657","https://openalex.org/W3016511734","https://openalex.org/W4231542079","https://openalex.org/W4234368842"],"related_works":["https://openalex.org/W3040388166","https://openalex.org/W2912747440","https://openalex.org/W2792786373","https://openalex.org/W7168282969","https://openalex.org/W2997606426","https://openalex.org/W2922494586","https://openalex.org/W3130057594","https://openalex.org/W3005414471","https://openalex.org/W3016511734","https://openalex.org/W2071993126"],"abstract_inverted_index":{"Disruption":[0],"of":[1,9,58,74,81,117,151,166,178],"plasma":[2],"membrane":[3,17,37,50,59,75,87,112,118,180,185],"integrity":[4],"is":[5],"a":[6,27,84,104,130],"primary":[7],"mechanism":[8],"nanoparticle":[10,108,154],"toxicity":[11],"in":[12,65,97,107,136,161,183,187],"cells.Mechanistic":[13],"studies":[14],"on":[15,29],"nanoparticle-induced":[16],"damage":[18,186],"have":[19],"been":[20],"commonly":[21],"performed":[22],"using":[23,83],"model":[24],"membranes":[25],"with":[26,46,134],"focus":[28],"symmetric":[30],"bilayers,":[31],"overlooking":[32],"the":[33,36,62,66,111,144,157,164,175,179],"fact":[34],"that":[35],"has":[38],"an":[39,171],"asymmetric":[40],"phospholipid":[41],"composition.In":[42],"this":[43],"thesis,":[44],"erythrocytes":[45,128],"normal":[47],"and":[48,61,153,191],"scrambled":[49,167],"asymmetry":[51,60,76],"were":[52],"utilized":[53],"to":[54,100,110,156],"examine":[55],"how":[56],"loss":[57,116],"resulting":[63],"alterations":[64],"outer":[67,146,181],"leaflet":[68,147,182],"lipid":[69,141,148,176,189],"composition":[70,165,177],"affect":[71],"nanoparticle-membrane":[72],"interactions.Loss":[73],"was":[77,94,113,159],"achieved":[78],"by":[79,90],"induction":[80],"eryptosis,":[82],"calcium":[85],"ionophore.Erythrocyte":[86],"disruption":[88],"(hemolysis)":[89],"plain":[91,138],"silica":[92],"nanoparticles":[93],"significantly":[95],"reduced":[96,160],"eryptotic":[98],"compared":[99],"healthy":[101,127],"cells.In":[102],"agreement,":[103],"significant":[105,123],"reduction":[106],"binding":[109,155],"observed":[114],"upon":[115],"asymmetry.The":[119],"particles":[120,139],"also":[121],"caused":[122],"cell":[124],"deformation,":[125],"changing":[126],"into":[129],"spheroid":[131],"shape.In":[132],"agreement":[133],"findings":[135,169],"cells,":[137],"disrupted":[140],"vesicles":[142,162,190],"mimicking":[143,163],"erythrocyte":[145],"composition.The":[149],"degree":[150],"disruption,":[152],"membrane,":[158],"membranes.Together,":[168],"indicate":[170],"important":[172],"role":[173],"for":[174],"nanoparticleinduced":[184],"both":[188],"erythrocytes.":[192]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}