{"id":"https://openalex.org/W6986909690","doi":null,"title":"The Role of Lipid Mediators in the Regulation of Macrophage Differentiation and Immune Function","display_name":"The Role of Lipid Mediators in the Regulation of Macrophage Differentiation and Immune Function","publication_year":2024,"publication_date":"2024-07-31","ids":{"openalex":"https://openalex.org/W6986909690"},"language":"en","primary_location":{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/98485","doi":null,"is_oa":false,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/98485","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087922078","display_name":"Kimberly Pistorius","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pistorius, K","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5087922078"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.8629999756813049},{"id":"https://openalex.org/keywords/efferocytosis","display_name":"efferocytosis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/protectins","display_name":"protectins","score":0.781000018119812},{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.8410000205039978},{"id":"https://openalex.org/keywords/macrophage-phenotype","display_name":"macrophage phenotype","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.36970001459121704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34540000557899475},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26109999418258667},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2515999972820282},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24690000712871552},{"id":"https://openalex.org/C168261976","wikidata":"https://www.wikidata.org/wiki/Q5347407","display_name":"Efferocytosis","level":4,"score":0.24420000612735748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24240000545978546}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/98485","doi":null,"is_oa":false,"landing_page_url":"https://qmro.qmul.ac.uk/xmlui/handle/123456789/98485","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8338000178337097,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2803887211","https://openalex.org/W2766435905","https://openalex.org/W2473681996","https://openalex.org/W2122405246","https://openalex.org/W265800703","https://openalex.org/W7126223491","https://openalex.org/W2623469171","https://openalex.org/W2792240904","https://openalex.org/W4237669910","https://openalex.org/W2602555822"],"abstract_inverted_index":{"Inflammation":[0],"is":[1,129,352,359],"a":[2,47,59,504],"necessary":[3],"process":[4,14],"in":[5,22,31,39,62,70,116,139,158,174,184,191,195,228,312,318,430,481,514,522],"fighting":[6],"infection":[7],"or":[8,286],"during":[9,80],"injury.":[10],"Subsequently,":[11],"the":[12,40,63,72,81,86,104,113,122,153,161,171,175,192,201,207,225,229,241,257,291,320,326,332,345,364,380,489,507],"active":[13],"of":[15,17,24,50,65,74,83,124,155,177,203,259,293,322,334,347,379,382,457,478,495],"resolution":[16,82,123,321,333,523],"inflammation":[18,323,335,339,362,407],"occurs,":[19],"which":[20,289,316,366],"assists":[21],"clearance":[23,73],"cell":[25,186],"debris":[26,79],"and":[27,30,34,77,112,145,235,265,270,297,300,341,375,397,408,452,472,491,512,517,519],"dead":[28],"cells":[29,76],"tissue":[32,117,303,313,453],"repair":[33],"regeneration":[35,118,314],"to":[36,151,206,224,252,324,328,337,344,369,401,445,449],"restore":[37,325],"homeostasis":[38],"tissue.":[41],"Recently,":[42],"it":[43],"was":[44,166,221,427,443],"determined":[45],"that":[46,120,130,358,385,416,441],"novel":[48,100],"family":[49],"lipid":[51],"mediators,":[52],"namely":[53,103],"specialised":[54],"pro-resolving":[55,135],"mediators":[56,132,157,227],"(SPMs),":[57],"had":[58],"vital":[60],"role":[61,505,521],"activation":[64],"resolution.":[66],"Macrophages":[67],"are":[68],"central":[69],"orchestrating":[71],"apoptotic":[75],"cellular":[78],"inflammation.":[84,125,349],"Here,":[85],"mechanism(s)":[87],"regulating":[88,515],"macrophage":[89,143,268,298],"function,":[90],"including":[91],"efferocytosis,":[92],"remain":[93],"incompletely":[94],"understood.":[95],"Recent":[96],"studies":[97],"identified":[98],"two":[99],"mediator":[101],"families,":[102],"n-3":[105,204],"docosapentaenoic":[106],"acid":[107,213],"(DPA)-derived":[108],"protectins":[109],"(PDn-3":[110],"DPA)":[111],"maresin":[114,310],"conjugates":[115,311],"(MCTRs)":[119],"regulate":[121],"My":[126],"overarching":[127],"hypothesis":[128],"these":[131,156,178,181,273,404,482,501],"exert":[133,450],"their":[134,520],"activities,":[136],"at":[137],"least":[138],"part,":[140],"via":[141],"modulating":[142],"phenotype":[144,269],"function.":[146,271],"Therefore,":[147],"I":[148,168,188],"set":[149],"out":[150],"detail":[152],"biology":[154,381],"macrophages.":[159],"Since":[160],"PDn-3":[162,230,262,508],"DPA":[163,205,220,231,234,251,263,285,509],"biosynthetic":[164,510],"pathway":[165,511],"unknown,":[167],"first":[169],"studied":[170],"enzymes":[172,239],"involved":[173],"production":[176,264],"mediators.":[179],"In":[180,255],"studies,":[182],"using":[183,469],"vitro":[185],"systems,":[187],"established":[189],"that,":[190],"initial":[193],"step":[194],"this":[196],"pathway,":[197],"15-lipoxygenases":[198],"(ALOX15)":[199],"catalysed":[200],"conversion":[202],"intermediate":[208],"allylic":[209],"epoxide,":[210],"16S,":[211,218],"17S-epoxy-7Z,10Z,12E,4E,19Z-docosapentaenoic":[212],"(16S,":[214],"17S-ePDn-3":[215,219],"DPA).":[216],"Thereafter,":[217],"enzymatically":[222],"converted":[223,249],"bioactive":[226],"metabolome,":[232],"PD1n-3":[233,287],"PD2n-3":[236],"DPA,":[237,288],"by":[238],"from":[240,388,461],"epoxide":[242,246],"hydrolase":[243,247],"family,":[244],"where":[245],"2":[248],"16S,17S-ePDn-3":[250,284],"PD2n-":[253],"3DPA.":[254],"addition,":[256],"inhibition":[258,486],"ALOX15":[260],"inhibited":[261],"altered":[266],"both":[267,488],"Yet,":[272],"biological":[274],"activities":[275],"were":[276,280,391,417],"rescued":[277],"when":[278,386,412],"macrophages":[279,305,460,518],"incubated":[281,392,421],"with":[282,361,393,414,419,422,434,465],"either":[283],"restored":[290],"expression":[292],"several":[294],"lineage":[295],"markers":[296],"efferocytosis":[299,426],"phagocytosis.":[301],"Additionally,":[302],"protective":[304,454,493],"produce,":[306],"among":[307],"other":[308],"SPMs,":[309],"(MCTRs),":[315],"assist":[317],"promoting":[319],"host":[327],"homeostasis.":[329],"However,":[330],"if":[331],"fails":[336],"occur,":[338],"persists":[340],"may":[342],"lead":[343,368],"development":[346],"chronic":[348,355],"Rheumatoid":[350],"arthritis":[351],"an":[353,476],"autoimmune":[354],"inflammatory":[356],"disease":[357],"associated":[360],"within":[363],"joints,":[365],"can":[367],"joint":[370,406,492],"damage":[371],"through":[372],"cartilage":[373,410],"degradation":[374],"bone":[376],"erosion.":[377],"Assessment":[378],"MCTR3":[383,394,435,442,466,496,513],"demonstrated":[384],"monocytes":[387,420,468,516],"arthritic":[389,402,431,462],"mice":[390,415,432,463],"ex":[395],"vivo":[396],"then":[398],"transferred":[399],"back":[400],"mice,":[403],"reduced":[405],"increased":[409],"integrity":[411],"compared":[413],"treated":[418,433,464],"vehicle":[423],"alone.":[424],"Macrophage":[425],"also":[428],"enhanced":[429],"reprogrammed":[436,467,497],"monocytes.":[437,498],"These":[438],"data":[439],"indicated":[440,475],"able":[444],"reprogramme":[446],"monocyte":[447,458],"responses":[448],"anti-inflammatory":[451],"activities.":[455],"Evaluation":[456],"derived":[459],"transcriptomic":[470],"profiling":[471],"flow":[473],"cytometry":[474],"upregulation":[477],"Arginase-1":[479],"(Arg1)":[480],"cells.":[483],"Furthermore,":[484],"Arg1":[485],"reversed":[487],"anti-arthritic":[490],"actions":[494],"Taken":[499],"together,":[500],"results":[502],"establish":[503],"for":[506],"responses.":[524]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}