{"id":"https://openalex.org/W6986810418","doi":null,"title":"Reducing toxicity in the treatment of lymphoma","display_name":"Reducing toxicity in the treatment of lymphoma","publication_year":2024,"publication_date":"2024-02-06","ids":{"openalex":"https://openalex.org/W6986810418"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/25152326","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Reducing_toxicity_in_the_treatment_of_lymphoma/25152326","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/thesis/Reducing_toxicity_in_the_treatment_of_lymphoma/25152326","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021039318","display_name":"Anna Santarsieri","orcid":"https://orcid.org/0000-0002-4449-2196","observed_orcids":["https://orcid.org/0000-0002-4449-2196"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anna Santarsieri (16676331)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5021039318"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.6919999718666077},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/procarbazine","display_name":"procarbazine","score":0.746999979019165},{"id":"https://openalex.org/keywords/dacarbazine","display_name":"dacarbazine","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-substitution","display_name":"drug substitution","score":0.7749999761581421},{"id":"https://openalex.org/keywords/primary-mediastinal-large-b-cell-lymphoma","display_name":"primary mediastinal B-cell lymphoma","score":0.9539999961853027},{"id":"https://openalex.org/keywords/da-epoch-r","display_name":"DA-EPOCH-R","score":0.8790000081062317},{"id":"https://openalex.org/keywords/post-transplant-lymphoproliferative-disorder","display_name":"post-transplant lymphoproliferative disorder","score":0.9800000190734863},{"id":"https://openalex.org/keywords/rituximab-monotherapy","display_name":"rituximab monotherapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/chemotherapy-free-treatment","display_name":"chemotherapy-free treatment","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hematopoietic-stem-and-progenitor-cells","display_name":"hematopoietic stem and progenitor cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mutation-burden","display_name":"mutational burden","score":0.8700000047683716},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779112685","wikidata":"https://www.wikidata.org/wiki/Q418656","display_name":"Procarbazine","level":5,"score":0.7990999817848206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7656999826431274},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6416000127792358},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.6121000051498413},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6118999719619751},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5796999931335449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5022000074386597},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4523000121116638},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.43860000371932983},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.37549999356269836},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.3707999885082245},{"id":"https://openalex.org/C2777580203","wikidata":"https://www.wikidata.org/wiki/Q3237100","display_name":"Leucosis","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.34850001335144043},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.3253999948501587},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2778191690","wikidata":"https://www.wikidata.org/wiki/Q422324","display_name":"Brentuximab vedotin","level":4,"score":0.28119999170303345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27869999408721924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2621999979019165},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.260699987411499}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:figshare.com:article/25152326","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Reducing_toxicity_in_the_treatment_of_lymphoma/25152326","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/25152326","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/thesis/Reducing_toxicity_in_the_treatment_of_lymphoma/25152326","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310096169","https://openalex.org/W7222227853","https://openalex.org/W4380079143","https://openalex.org/W4395044158","https://openalex.org/W4308128474","https://openalex.org/W4405267311","https://openalex.org/W1987554969","https://openalex.org/W2690710466","https://openalex.org/W2092561943","https://openalex.org/W2746798179"],"abstract_inverted_index":{"While":[0],"prognosis":[1],"for":[2,43,49,195,221],"lymphoma":[3,67,146,159,294],"patients":[4,178,233],"has":[5],"improved":[6],"significantly":[7],"in":[8,54,83,91,135,157,190,227,238,267,273,290],"recent":[9],"years":[10],"due":[11],"to":[12,26,38,61,103,108,203],"modern":[13],"treatments,":[14],"diagnostics":[15],"and":[16,20,69,130,138,265],"imaging":[17],"techniques,":[18],"short-term":[19],"late":[21],"effects":[22],"of":[23,47,73,112,118,127,142,168,232,293,297],"treatment":[24,48,72,160,220],"continue":[25],"have":[27,87,286],"a":[28,58,184,256],"detrimental":[29],"impact":[30,117,302],"on":[31,120,303],"their":[32],"health.":[33,306],"This":[34,192],"project":[35,193],"set":[36],"out":[37],"investigate":[39],"three":[40],"different":[41],"strategies":[42,79,284],"reducing":[44,109,291],"the":[45,105,110,116,196,204,239,278,283],"toxicity":[46,111,175],"lymphoma:":[50],"i)":[51],"drug":[52],"substitution":[53,171],"Hodgkin":[55,145,158],"lymphoma,":[56],"(ii)":[57],"radiotherapy-free":[59],"approach":[60,258],"treating":[62],"primary":[63],"mediastinal":[64],"large":[65],"B-cell":[66],"(PMBL),":[68],"(iii)":[70],"chemotherapy-free":[71],"post-transplant":[74],"lymphoproliferative":[75],"disorder":[76],"(PTLD).":[77],"These":[78],"are":[80,288],"commonly":[81],"used":[82],"clinical":[84,94,274],"practice":[85,269],"but":[86],"not":[88],"been":[89],"tested":[90],"prospective,":[92],"randomised":[93],"trials.":[95,275],"Retrospective,":[96],"observational,":[97],"multicentre":[98],"study":[99,230],"designs":[100],"were":[101,151],"chosen":[102],"evaluate":[104],"above":[106],"approaches":[107],"treatment.":[113,295],"To":[114],"assess":[115],"chemotherapy":[119,298],"stem":[121,137],"cell":[122],"genomic":[123,305],"health,":[124],"an":[125,162],"analysis":[126],"mutation":[128,188],"burden":[129,189],"mutational":[131,206],"signatures":[132],"was":[133,245],"performed":[134],"haematopoietic":[136],"progenitor":[139],"cells":[140],"(HSPC)":[141],"previously":[143],"treated":[144,179],"patients.":[147],"The":[148,170],"key":[149],"findings":[150],"that":[152,199,255,282],"replacing":[153],"procarbazine":[154,200],"with":[155,180,210,259],"dacarbazine":[156],"maintains":[161],"excellent":[163],"36-month":[164],"progression-free":[165],"survival":[166],"(PFS)":[167],"92.4%.":[169],"also":[172,301],"confers":[173],"several":[174],"benefits.":[176],"Additionally,":[177],"dacarbazine-containing":[181],"regimens":[182],"had":[183],"far":[185],"lower":[186],"excess":[187],"HSPC.":[191],"showed":[194],"first":[197],"time":[198],"is":[201,217,263],"linked":[202],"SBS25":[205],"signature.":[207],"R-DA-EPOCH":[208],"(Rituximab":[209],"dose-adjusted":[211],"Etoposide,":[212],"Prednisolone,":[213],"Vincristine,":[214],"Cyclophosphamide,":[215],"Doxorubixin)":[216],"highly":[218],"effective":[219,264,289],"PMBL":[222],"(3-year":[223],"PFS":[224],"92.8%).":[225],"However,":[226],"this":[228],"real-world":[229,268,279],"31%":[231],"received":[234],"consolidative":[235],"radiotherapy,":[236],"while":[237],"landmark":[240],"Phase":[241],"II":[242],"trial":[243],"radiotherapy":[244],"omitted(Dunleavy":[246],"et":[247],"al.,":[248],"2013).":[249],"In":[250,276],"PTLD,":[251],"our":[252],"data":[253,280],"suggest":[254,281],"risk-stratified":[257],"first-line":[260],"Rituximab":[261],"monotherapy":[262],"safe":[266],"as":[270,272],"well":[271],"conclusion,":[277],"I":[285],"studied":[287],"toxicities":[292],"Choice":[296],"regimen":[299],"may":[300],"HSPC":[304]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-10T00:00:00"}
