{"id":"https://openalex.org/W6986795278","doi":null,"title":"Regulation of metabolism by DNA-binding ability and acetylation of FOXO in Drosophila","display_name":"Regulation of metabolism by DNA-binding ability and acetylation of FOXO in Drosophila","publication_year":2023,"publication_date":"2023-11-17","ids":{"openalex":"https://openalex.org/W6986795278"},"language":"en","primary_location":{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:71645","doi":null,"is_oa":true,"landing_page_url":"http://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","pdf_url":"https://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061647138","display_name":"Bruna Di Giacomo","orcid":"https://orcid.org/0000-0002-7153-7927","observed_orcids":["https://orcid.org/0000-0002-7153-7927"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Di Giacomo, Bruna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061647138"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxo","display_name":"FOXO","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dfoxo","display_name":"dFOXO","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acetylation","display_name":"acetylation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/insulin-igf-1-signaling","display_name":"insulin/IGF-1 signaling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/energy-homeostasis","display_name":"energy homeostasis","score":0.7459999918937683},{"id":"https://openalex.org/keywords/metabolism","display_name":"metabolism","score":0.824999988079071},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.7099999785423279},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.7379999756813049},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6579999923706055},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sugar-starvation","display_name":"sugar starvation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/methionine-depletion","display_name":"methionine depletion","score":0.9440000057220459},{"id":"https://openalex.org/keywords/lipid-utilization","display_name":"lipid utilization","score":0.6299999952316284},{"id":"https://openalex.org/keywords/high-sugar-diet","display_name":"high-sugar diet","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.8623999953269958},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.7023000121116638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6466000080108643},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6137999892234802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.583299994468689},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.43709999322891235},{"id":"https://openalex.org/C2908554999","wikidata":"https://www.wikidata.org/wiki/Q905506","display_name":"Forkhead Transcription Factors","level":4,"score":0.41290000081062317},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.40950000286102295},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38830000162124634},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.37610000371932983},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.3736000061035156},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.35679998993873596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3474000096321106},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.33799999952316284},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3230000138282776},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3215999901294708},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.3188999891281128},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.3156000077724457},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.2567000091075897}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:71645","doi":null,"is_oa":true,"landing_page_url":"http://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","pdf_url":"https://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:71645","doi":null,"is_oa":true,"landing_page_url":"http://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","pdf_url":"https://kups.ub.uni-koeln.de/71645/1/Dissertation_Bruna%20Di%20Giacomo.pdf","source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6986795278.pdf","grobid_xml":"https://content.openalex.org/works/W6986795278.grobid-xml"},"referenced_works_count":265,"referenced_works":["https://openalex.org/W1086165218","https://openalex.org/W1497754562","https://openalex.org/W1508829110","https://openalex.org/W1514533495","https://openalex.org/W1583767403","https://openalex.org/W1585352605","https://openalex.org/W1898922522","https://openalex.org/W1959935957","https://openalex.org/W1964801445","https://openalex.org/W1964876127","https://openalex.org/W1965580206","https://openalex.org/W1965818907","https://openalex.org/W1966132436","https://openalex.org/W1966262847","https://openalex.org/W1969353942","https://openalex.org/W1969435183","https://openalex.org/W1969832012","https://openalex.org/W1970083434","https://openalex.org/W1972597570","https://openalex.org/W1972657835","https://openalex.org/W1973094805","https://openalex.org/W1973622869","https://openalex.org/W1974178287","https://openalex.org/W1976050844","https://openalex.org/W1977351943","https://openalex.org/W1977466283","https://openalex.org/W1977869829","https://openalex.org/W1978489579","https://openalex.org/W1978714931","https://openalex.org/W1979499609","https://openalex.org/W1979877873","https://openalex.org/W1981614332","https://openalex.org/W1984782606","https://openalex.org/W1985246079","https://openalex.org/W1985425785","https://openalex.org/W1985478578","https://openalex.org/W1987738803","https://openalex.org/W1988007786","https://openalex.org/W1988012917","https://openalex.org/W1988068820","https://openalex.org/W1991199546","https://openalex.org/W1991476773","https://openalex.org/W1991782854","https://openalex.org/W1992609426","https://openalex.org/W1993983296","https://openalex.org/W1995008569","https://openalex.org/W1996200651","https://openalex.org/W1996522069","https://openalex.org/W1997711723","https://openalex.org/W1998443707","https://openalex.org/W1998674552","https://openalex.org/W2000962819","https://openalex.org/W2000966175","https://openalex.org/W2003219770","https://openalex.org/W2003779663","https://openalex.org/W2007530728","https://openalex.org/W2007636825","https://openalex.org/W2009010832","https://openalex.org/W2009607823","https://openalex.org/W2012195830","https://openalex.org/W2012956466","https://openalex.org/W2013388632","https://openalex.org/W2014885180","https://openalex.org/W2015843858","https://openalex.org/W2016269827","https://openalex.org/W2018080324","https://openalex.org/W2023181503","https://openalex.org/W2024123645","https://openalex.org/W2028962269","https://openalex.org/W2030732918","https://openalex.org/W2031078895","https://openalex.org/W2032189098","https://openalex.org/W2032306298","https://openalex.org/W2033261332","https://openalex.org/W2033442515","https://openalex.org/W2033682352","https://openalex.org/W2034201098","https://openalex.org/W2034415072","https://openalex.org/W2035289883","https://openalex.org/W2036075031","https://openalex.org/W2036837630","https://openalex.org/W2037341437","https://openalex.org/W2038017425","https://openalex.org/W2038120788","https://openalex.org/W2042986568","https://openalex.org/W2045418941","https://openalex.org/W2045992894","https://openalex.org/W2046989794","https://openalex.org/W2047066418","https://openalex.org/W2047667443","https://openalex.org/W2047683380","https://openalex.org/W2048376025","https://openalex.org/W2049009766","https://openalex.org/W2049266192","https://openalex.org/W2049739654","https://openalex.org/W2051397875","https://openalex.org/W2052722944","https://openalex.org/W2053493267","https://openalex.org/W2055893161","https://openalex.org/W2056388945","https://openalex.org/W2056418435","https://openalex.org/W2056525941","https://openalex.org/W2056894341","https://openalex.org/W2057077123","https://openalex.org/W2058381061","https://openalex.org/W2058768125","https://openalex.org/W2058803981","https://openalex.org/W2059222296","https://openalex.org/W2060535020","https://openalex.org/W2062070852","https://openalex.org/W2062629127","https://openalex.org/W2064412448","https://openalex.org/W2065197926","https://openalex.org/W2065552408","https://openalex.org/W2066473815","https://openalex.org/W2067951272","https://openalex.org/W2070745300","https://openalex.org/W2071656971","https://openalex.org/W2074794423","https://openalex.org/W2074930831","https://openalex.org/W2076174368","https://openalex.org/W2076708045","https://openalex.org/W2078156067","https://openalex.org/W2078639396","https://openalex.org/W2079106483","https://openalex.org/W2080863734","https://openalex.org/W2081200438","https://openalex.org/W2081267709","https://openalex.org/W2082966250","https://openalex.org/W2083850113","https://openalex.org/W2083984814","https://openalex.org/W2084013192","https://openalex.org/W2088122871","https://openalex.org/W2088749993","https://openalex.org/W2089741175","https://openalex.org/W2090759987","https://openalex.org/W2096576561","https://openalex.org/W2096935190","https://openalex.org/W2097723927","https://openalex.org/W2098146588","https://openalex.org/W2098563852","https://openalex.org/W2099283141","https://openalex.org/W2101735670","https://openalex.org/W2103428092","https://openalex.org/W2103716351","https://openalex.org/W2105283833","https://openalex.org/W2105746752","https://openalex.org/W2106655937","https://openalex.org/W2107368610","https://openalex.org/W2107601240","https://openalex.org/W2108570063","https://openalex.org/W2109639997","https://openalex.org/W2110839026","https://openalex.org/W2112023460","https://openalex.org/W2112399708","https://openalex.org/W2114008231","https://openalex.org/W2114713612","https://openalex.org/W2114927063","https://openalex.org/W2115202941","https://openalex.org/W2115691812","https://openalex.org/W2116461852","https://openalex.org/W2117188757","https://openalex.org/W2119667044","https://openalex.org/W2121881475","https://openalex.org/W2124898423","https://openalex.org/W2126525177","https://openalex.org/W2127337885","https://openalex.org/W2128648826","https://openalex.org/W2128655116","https://openalex.org/W2128807350","https://openalex.org/W2129438003","https://openalex.org/W2132716318","https://openalex.org/W2134138119","https://openalex.org/W2137035181","https://openalex.org/W2140803082","https://openalex.org/W2142983739","https://openalex.org/W2144653830","https://openalex.org/W2146685672","https://openalex.org/W2153551557","https://openalex.org/W2154058908","https://openalex.org/W2155098040","https://openalex.org/W2155905348","https://openalex.org/W2156403523","https://openalex.org/W2157725915","https://openalex.org/W2158678395","https://openalex.org/W2159540848","https://openalex.org/W2161007406","https://openalex.org/W2161197995","https://openalex.org/W2162434225","https://openalex.org/W2162665049","https://openalex.org/W2162711901","https://openalex.org/W2166208596","https://openalex.org/W2166256210","https://openalex.org/W2167795228","https://openalex.org/W2168778208","https://openalex.org/W2169250745","https://openalex.org/W2171241286","https://openalex.org/W2171391341","https://openalex.org/W2171677988","https://openalex.org/W2174037104","https://openalex.org/W2179506685","https://openalex.org/W2192708678","https://openalex.org/W2196594270","https://openalex.org/W2261050402","https://openalex.org/W2273121121","https://openalex.org/W2279382765","https://openalex.org/W2280484373","https://openalex.org/W2303025129","https://openalex.org/W2313389922","https://openalex.org/W2331547930","https://openalex.org/W2336226589","https://openalex.org/W2461170015","https://openalex.org/W2492370100","https://openalex.org/W2507611908","https://openalex.org/W2533366885","https://openalex.org/W2542827168","https://openalex.org/W2574492808","https://openalex.org/W2592240998","https://openalex.org/W2592281222","https://openalex.org/W2595188646","https://openalex.org/W2765507458","https://openalex.org/W2769153103","https://openalex.org/W2773071392","https://openalex.org/W2775819028","https://openalex.org/W2782694160","https://openalex.org/W2786417636","https://openalex.org/W2788825876","https://openalex.org/W2799840159","https://openalex.org/W2860743873","https://openalex.org/W2888242953","https://openalex.org/W2914541321","https://openalex.org/W2923371337","https://openalex.org/W2924622926","https://openalex.org/W2938027664","https://openalex.org/W2938944285","https://openalex.org/W2949821096","https://openalex.org/W2952520583","https://openalex.org/W2953550896","https://openalex.org/W2956809915","https://openalex.org/W2965665877","https://openalex.org/W2967744717","https://openalex.org/W2970686316","https://openalex.org/W2974441752","https://openalex.org/W3006122192","https://openalex.org/W3011945761","https://openalex.org/W3013641498","https://openalex.org/W3016696822","https://openalex.org/W3032648743","https://openalex.org/W3089485706","https://openalex.org/W3113827231","https://openalex.org/W3119306593","https://openalex.org/W3171153188","https://openalex.org/W3181871106","https://openalex.org/W3201060420","https://openalex.org/W3215990762","https://openalex.org/W4206313894","https://openalex.org/W4210256384","https://openalex.org/W4210654108","https://openalex.org/W4210788856","https://openalex.org/W4211058450","https://openalex.org/W4289526690","https://openalex.org/W4310497573","https://openalex.org/W4313531093","https://openalex.org/W4321481420","https://openalex.org/W6969068832"],"related_works":["https://openalex.org/W7065919171","https://openalex.org/W4413418310","https://openalex.org/W2157054680","https://openalex.org/W2128557797","https://openalex.org/W3082999105","https://openalex.org/W2078094378","https://openalex.org/W2002402108","https://openalex.org/W2090760489","https://openalex.org/W6929329921","https://openalex.org/W2413873740"],"abstract_inverted_index":{"Population":[0],"ageing":[1],"is":[2,20,99,310],"a":[3,74,188,203,251,257],"major":[4],"social":[5],"problem,":[6],"and":[7,43,57,66,83,105,143,180,221,361],"researchers":[8],"are":[9,51,294],"exploring":[10],"ways":[11],"to":[12,87,135,171,194,235,290,307,338],"promote":[13],"healthy":[14],"ageing.":[15],"One":[16],"area":[17],"of":[18,34,54,63,80,140,148,155,175,231,250,260,265,272,285,296,325],"investigation":[19],"the":[21,31,64,78,90,95,111,130,137,146,152,156,173,192,207,226,247,269,273,282,286,354],"evolutionarily":[22],"conserved":[23],"insulin-insulin":[24],"like":[25],"growth":[26],"factor":[27],"signaling":[28],"pathway":[29,56],"(IIS),":[30],"reduced":[32],"activity":[33],"which":[35,281],"has":[36],"been":[37,59,121],"largely":[38],"associated":[39,93,358],"with":[40,94,107,225,359],"improved":[41],"health":[42],"longevity":[44],"in":[45,77,117,145,191,280,366],"different":[46,91],"species.":[47],"FOXO":[48,115,232],"transcription":[49],"factors":[50],"downstream":[52],"effectors":[53],"this":[55,125,176,348],"have":[58,119,202],"identified":[60],"as":[61,262,340],"mediators":[62],"healthspan":[65],"lifespan":[67,179],"benefits.":[68],"Besides":[69],"regulating":[70],"ageing,":[71],"FOXOs":[72],"play":[73],"crucial":[75,189],"role":[76,190,259],"regulation":[79,116,147],"energy":[81,342],"homeostasis":[82],"metabolism.":[84,181],"In":[85,124,151,268,346],"order":[86],"coordinate":[88],"all":[89],"functions":[92,292,357],"protein,":[96],"their":[97],"action":[98],"specifically":[100],"regulated":[101],"by":[102],"post-translational":[103],"modifications":[104],"interactions":[106],"binding":[108],"partners.":[109],"However,":[110],"molecular":[112],"mechanisms":[113,365],"behind":[114],"vivo":[118],"not":[120],"fully":[122],"elucidated.":[123],"PhD":[126,349],"project,":[127,274],"I":[128,158,215,275],"used":[129,159,276],"model":[131],"organism":[132],"Drosophila":[133],"melanogaster":[134],"investigate":[136],"specific":[138,355],"contribution":[139],"DNA-binding":[141,283,315],"ability":[142,284],"acetylation":[144,186,211,219,228],"FOXO-related":[149],"functions.":[150],"first":[153],"part":[154,271],"study,":[157],"previously":[160],"generated":[161,216],"mutant":[162,278],"flies":[163,245,279],"expressing":[164],"constitutively":[165,241],"acetylated":[166,242],"or":[167],"deacetylated":[168],"dFOXO":[169,185,213,243,261,277,360],"proteins":[170],"study":[172,350],"influence":[174],"modification":[177],"on":[178,313,353,362],"We":[182],"found":[183],"that":[184,293,304,332],"plays":[187],"response":[193,306],"yeast":[195],"starvation":[196,309,323],"and,":[197],"partially,":[198],"cholesterol":[199],"starvation.":[200,345],"To":[201],"deeper":[204],"insight":[205],"into":[206],"lysine":[208],"residues":[209],"whose":[210],"regulates":[212],"function,":[214],"novel":[217],"partial":[218],"mutants":[220,334],"observed":[222,331],"overlapping":[223],"phenotypes":[224],"complete":[227],"mutants.":[229],"Acetylation":[230],"also":[233],"seemed":[234],"drive":[236],"metabolism":[237],"towards":[238],"lipogenesis.":[239],"Moreover,":[240,329],"protected":[244],"from":[246,336],"detrimental":[248],"effects":[249],"high-sugar":[252],"diet.":[253],"Finally,":[254],"we":[255,330],"described":[256],"new":[258],"potential":[263],"mediator":[264],"methionine":[266],"depletion.":[267],"second":[270],"protein":[287],"was":[288],"abolished":[289],"identify":[291],"independent":[295],"its":[297,314,326,363],"direct":[298],"transcriptional":[299,327],"ability.":[300,328],"Our":[301],"results":[302],"indicate":[303],"dFOXO-mediated":[305],"sugar":[308],"completely":[311],"dependent":[312],"ability,":[316],"whereas":[317],"it":[318],"promotes":[319],"lipid":[320],"usage":[321],"under":[322],"independently":[324],"dFOXO-DBD":[333],"switch":[335],"carbohydrates":[337],"lipids":[339],"preferential":[341],"source":[343],"upon":[344],"conclusion,":[347],"sheds":[351],"light":[352],"metabolic":[356],"regulatory":[364],"vivo.":[367]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
