{"id":"https://openalex.org/W6986499712","doi":null,"title":"Prediction of the dynamic behavior of photoautotrophic growth of an oleaginous alga using a multiscale metabolic model","display_name":"Prediction of the dynamic behavior of photoautotrophic growth of an oleaginous alga using a multiscale metabolic model","publication_year":2019,"publication_date":"2019-06-17","ids":{"openalex":"https://openalex.org/W6986499712"},"language":"en","primary_location":{"id":"pmh:oai:www.bdigital.unal.edu.co:73176","doi":null,"is_oa":false,"landing_page_url":"http://bdigital.unal.edu.co/73176/1/Thesis-ESP.pdf","pdf_url":"http://bdigital.unal.edu.co/73176/1/Thesis-ESP.pdf","source":{"id":"https://openalex.org/S4406922821","display_name":"Repositorio Institucional UN - Biblioteca Digital","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesis/trabajos de grado - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.unal.edu.co/handle/unal/76605","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008704515","display_name":"Juan D. Tibocha\u2010Bonilla","orcid":"https://orcid.org/0000-0001-7357-8629","observed_orcids":["https://orcid.org/0000-0001-7357-8629"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tibocha Bonilla, Juan David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008704515"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":0.7846999764442444,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.21449999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleaginous-microalgae","display_name":"oleaginous microalgae","score":0.875},{"id":"https://openalex.org/keywords/chlorella-vulgaris","display_name":"Chlorella vulgaris","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.5230000019073486},{"id":"https://openalex.org/keywords/lipid-productivity","display_name":"lipid productivity","score":0.5960000157356262},{"id":"https://openalex.org/keywords/genome-scale-metabolic-models","display_name":"genome-scale metabolic models","score":0.7940000295639038},{"id":"https://openalex.org/keywords/light-intensity","display_name":"light intensity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nitrogen-limitation","display_name":"nitrogen limitation","score":0.996999979019165},{"id":"https://openalex.org/keywords/circadian-oscillations","display_name":"circadian oscillations","score":0.8489999771118164},{"id":"https://openalex.org/keywords/biofuel-feedstock","display_name":"biofuel feedstock","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.71670001745224},{"id":"https://openalex.org/C2992619708","wikidata":"https://www.wikidata.org/wiki/Q309972","display_name":"Chlorella vulgaris","level":3,"score":0.5770000219345093},{"id":"https://openalex.org/C46423501","wikidata":"https://www.wikidata.org/wiki/Q830654","display_name":"Irradiance","level":2,"score":0.5383999943733215},{"id":"https://openalex.org/C3020368824","wikidata":"https://www.wikidata.org/wiki/Q6546192","display_name":"Light intensity","level":2,"score":0.5254999995231628},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.47110000252723694},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C204983608","wikidata":"https://www.wikidata.org/wiki/Q2111958","display_name":"Productivity","level":2,"score":0.42660000920295715},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C53991642","wikidata":"https://www.wikidata.org/wiki/Q128991","display_name":"Biofuel","level":2,"score":0.3765000104904175},{"id":"https://openalex.org/C77405623","wikidata":"https://www.wikidata.org/wiki/Q598451","display_name":"System dynamics","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36890000104904175},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.3668000102043152},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.36010000109672546},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.3573000133037567},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C141123601","wikidata":"https://www.wikidata.org/wiki/Q6935072","display_name":"Multiscale modeling","level":2,"score":0.29440000653266907},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C2776330181","wikidata":"https://www.wikidata.org/wiki/Q18358244","display_name":"Maximization","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2533000111579895}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.bdigital.unal.edu.co:73176","doi":null,"is_oa":false,"landing_page_url":"http://bdigital.unal.edu.co/73176/1/Thesis-ESP.pdf","pdf_url":"http://bdigital.unal.edu.co/73176/1/Thesis-ESP.pdf","source":{"id":"https://openalex.org/S4406922821","display_name":"Repositorio Institucional UN - Biblioteca Digital","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Tesis/trabajos de grado - Thesis"},{"id":"pmh:oai:repositorio.unal.edu.co:unal/76605","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unal.edu.co/handle/unal/76605","pdf_url":"https://repositorio.unal.edu.co/handle/unal/76605","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Repositorio UN","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.unal.edu.co:unal/76605","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.unal.edu.co/handle/unal/76605","pdf_url":"https://repositorio.unal.edu.co/handle/unal/76605","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Repositorio UN","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.4000000059604645,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6986499712.pdf","grobid_xml":"https://content.openalex.org/works/W6986499712.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3153313589","https://openalex.org/W7116859597","https://openalex.org/W2019644045","https://openalex.org/W2590442939","https://openalex.org/W2884441915","https://openalex.org/W1972959843","https://openalex.org/W2766638823","https://openalex.org/W2970121679","https://openalex.org/W2766908100","https://openalex.org/W2617355928"],"abstract_inverted_index":{"Background:":[0],"The":[1,60],"maximization":[2],"of":[3,57,71,101,123,153,159,175,193,198],"lipid":[4,102,110,145,150,217],"productivity":[5,151],"in":[6,33],"microalgae":[7],"is":[8],"crucial":[9],"for":[10,54,235],"the":[11,55,67,105,121,173,179,191],"biofuel":[12],"industry":[13],"and":[14,97,109,129,181,195,203,225],"it":[15],"can":[16,228],"be":[17,229],"achieved":[18],"by":[19,64],"manipulating":[20],"their":[21],"metabolism.":[22],"However,":[23],"little":[24],"efforts":[25],"have":[26],"been":[27],"made":[28],"to":[29,37,41,89,137,189,209,231],"apply":[30],"metabolic":[31,69],"models":[32],"a":[34,51,80,86,139,149,156,168,211],"dynamic":[35,52,169],"framework":[36,53,61,170,221],"predict":[38,90,190,232],"possible":[39],"outcomes":[40],"scenarios":[42],"observed":[43],"at":[44,155,177],"an":[45],"industrial":[46,236],"scale.":[47,183],"Here":[48,165],"we":[49,133,166],"present":[50],"simulation":[56],"large-scale":[58],"photobioreactors.":[59],"was":[62,187],"generated":[63,167],"merging":[65],"together":[66],"genome-scale":[68],"model":[70,88,136,186],"Chlorella":[72],"vulgaris":[73,200],"(iCZ843)":[74],"with":[75],"reactor-scale":[76],"parameters,":[77],"thus":[78,147],"yielding":[79],"multiscale":[81,87,185],"model.":[82],"Results:":[83],"We":[84],"used":[85,134],"growth":[91,108,194],"trends":[92],"under":[93,112],"different":[94],"light":[95,127,202],"intensities":[96],"nitrogen":[98,113,204],"concentrations.":[99],"Simulations":[100],"accumulation":[103],"quantified":[104],"trade-off":[106],"between":[107],"biosynthesis":[111],"limitation.":[114],"Moreover,":[115],"our":[116,135],"modeling":[117,174,220],"approach":[118],"quantitatively":[119],"predicted":[120],"dependence":[122],"microalgal":[124],"metabolism":[125,224],"on":[126,201],"intensity":[128,158],"circadian":[130],"oscillations.":[131],"Finally,":[132],"design":[138],"reactor":[140,182],"irradiance":[141,213],"profile":[142,214],"that":[143,171,215],"maximized":[144],"accumulation,":[146],"achieving":[148],"increase":[152],"46%":[154],"constant":[157],"966":[160],"\u03bcE":[161],"m^(-2)":[162],"s^(-1).":[163],"Conclusions:":[164],"combines":[172],"phenomena":[176],"both":[178],"genome":[180],"This":[184],"employed":[188],"sensitivity":[192],"composition":[196],"variation":[197],"C.":[199],"levels,":[205],"as":[206,208],"well":[207],"find":[210],"suitable":[212],"maximizes":[216],"productivity.":[218],"Our":[219],"elucidated":[222],"how":[223],"external":[226],"factors":[227],"combined":[230],"optimized":[233],"parameters":[234],"applications.":[237]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
