{"id":"https://openalex.org/W69838714","doi":null,"title":"Implication du r\u00e9cepteur TLR9 au cours de l'infection par Leishmania major : \u00e9tude du r\u00f4le des cellules dendritiques et des macrophages","display_name":"Implication du r\u00e9cepteur TLR9 au cours de l'infection par Leishmania major : \u00e9tude du r\u00f4le des cellules dendritiques et des macrophages","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W69838714","mag":"69838714"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/817094","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/817094","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10068/817094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088488212","display_name":"Faihaa Hkima Abou Fakher","orcid":"https://orcid.org/0000-0002-0900-9381","observed_orcids":["https://orcid.org/0000-0002-0900-9381"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Faihaa Hkima Abou Fakher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0900-9381","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5088488212"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.5547000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.323199987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leishmaniasis","display_name":"leishmaniasis","score":0.843999981880188},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9259999990463257},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tlr9-deficient-mice","display_name":"TLR9-deficient mice","score":0.8930000066757202},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/myeloid-dendritic-cells","display_name":"myeloid dendritic cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.6930000185966492},{"id":"https://openalex.org/keywords/parasite-dna","display_name":"parasite DNA","score":0.6039999723434448},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7588770985603333},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5977346897125244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4857664406299591},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3977944850921631},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16786962747573853},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09627005457878113},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07190516591072083},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/817094","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/817094","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:69838714","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2008PA077090","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:hdl:10068/817094","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/817094","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392428129","https://openalex.org/W1962910304","https://openalex.org/W2794516063","https://openalex.org/W2093951219","https://openalex.org/W1900164003","https://openalex.org/W2884880076","https://openalex.org/W2911044353","https://openalex.org/W7057140301","https://openalex.org/W7100337424","https://openalex.org/W2801064821"],"abstract_inverted_index":{"Au":[0],"cours":[1,234],"de":[2,20,52,76,79,92,101,128,132,140,148,167,201,218,235,246],"l'infection":[3,28],"par":[4,29,98,180,240],"L":[5,30,193],"major,":[6],"les":[7,48,57,68,99,114,144,198,212,225,241,258],"souris":[8,32,41,49,69,106,117,159,189,228],"C57BL/6":[9,33,107,160,190],"sont":[10],"resistantes":[11],"et":[12,94,124,161,191],"developpent":[13],"une":[14],"reponse":[15,63,169,237],"Th1.":[16],"Pour":[17],"connaitre":[18],"l'impact":[19],"TLR9":[21,147,243],"dans":[22,56],"ce":[23,205,249],"modele,":[24],"nous":[25,174,251],"avons":[26,72,135,175],"suivi":[27],"majorees":[31],"invalidees":[34],"pour":[35],"le":[36,74,209],"gene":[37],"codant":[38],"TLR9.":[39,85,133,192,219],"Les":[40,151],"TLR9\u00af/\u00af":[42,164],"s'averent":[43],"transitoirement":[44],"plus":[45],"sensibles":[46],"que":[47,61,137,208,250],"C57BL/6.":[50,229],"L'analyse":[51],"l'expression":[53,89],"des":[54,90,95,105,116,122,125,156,158,163,170,183,188,215,227],"cytokines":[55,96],"ganglions":[58],"drainants,":[59],"demontre":[60,136,256],"la":[62,129,154,168,236],"Th1":[64],"est":[65,195,244],"retardee":[66],"chez":[67,113,257],"TLR9\u00af/\u00af.":[70],"Nous":[71,134],"analyse":[73],"phenotype":[75],"plusieurs":[77],"sous-types":[78],"cellules":[80,171],"dendritiques":[81],"(DC)":[82],"qui":[83,206],"expriment":[84],"Le":[86],"parasite":[87,210],"induit":[88],"molecules":[91],"co-stimulation":[93],"pro-inflammatoires":[97],"DC":[100,126,145,157],"moelle":[102],"osseuse":[103],"(BMDC)":[104],"alors":[108],"qu'il":[109],"ne":[110,252],"l'induit":[111],"pas":[112,254],"BMDC":[115],"TLRg\u00af/\u00af.":[118],"De":[119],"meme,":[120],"l'activation":[121,166,179],"plasmacytoides":[123],"conventionnelles":[127],"rate":[130],"depend":[131],"l'ADN":[138,221],"genomique":[139],"L.":[141,181],"Major":[142,182],"active":[143,223,245],"via":[146],"facon":[149,247],"specifique.":[150],"differences":[152],"entre":[153],"stimulation":[155],"celle":[162],"affectent":[165],"T.":[172],"Parallelement,":[173],"etudie":[176],"in":[177],"vitro":[178],"macrophages":[184],"peritoneaux":[185],"(M\u03a6)":[186],"provenant":[187],"major":[194],"incapable":[196],"d'activer":[197],"M\u03a6":[199,216,226],"issus":[200],"ces":[202],"deux":[203],"lignees,":[204],"confirme":[207],"inhibe":[211],"fonctions":[213],"defensives":[214],"independamment":[217],"Cependant":[220],"parasitaire":[222],"faiblement":[224],"Nos":[230],"resultats":[231],"suggerent":[232],"qu'au":[233],"immune":[238],"assuree":[239],"DC,":[242],"precoce;":[248],"l'avons":[253],"encore":[255],"M\u03a6,":[259],"principaux":[260],"hotes":[261],"du":[262],"parasite.":[263]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}