{"id":"https://openalex.org/W69838075","doi":null,"title":"Psychopharmacology of prepulse inhibition in mice.","display_name":"Psychopharmacology of prepulse inhibition in mice.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W69838075","mag":"69838075","pmid":"https://pubmed.ncbi.nlm.nih.gov/8955560"},"language":"en","primary_location":{"id":"pmid:8955560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8955560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Chinese journal of physiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062760806","display_name":"Stephanie C. Dulawa","orcid":"https://orcid.org/0000-0003-1281-782X","observed_orcids":["https://orcid.org/0000-0003-1281-782X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S C Dulawa","raw_affiliation_strings":["Department of Neuroscience, University of California at San Diego, La Jolla 92093-0804, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, University of California at San Diego, La Jolla 92093-0804, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034576114","display_name":"Mark A. Geyer","orcid":"https://orcid.org/0000-0001-6137-9331","observed_orcids":["https://orcid.org/0000-0001-6137-9331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Geyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6189,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.88544049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"3","first_page":"139","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prepulse-inhibition","display_name":"prepulse inhibition","score":1.0},{"id":"https://openalex.org/keywords/sensorimotor-gating","display_name":"sensorimotor gating","score":0.9729999899864197},{"id":"https://openalex.org/keywords/startle-response","display_name":"startle response","score":0.9330000281333923},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/d-amphetamine","display_name":"d-amphetamine","score":0.890999972820282},{"id":"https://openalex.org/keywords/phencyclidine","display_name":"phencyclidine","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.9710000157356262},{"id":"https://openalex.org/keywords/psychopharmacology","display_name":"psychopharmacology","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.9951575994491577},{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.8407654762268066},{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.7799420356750488},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.5740727782249451},{"id":"https://openalex.org/C2779705967","wikidata":"https://www.wikidata.org/wiki/Q2271368","display_name":"Sensory gating","level":3,"score":0.5560123324394226},{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.5453717708587646},{"id":"https://openalex.org/C2777845764","wikidata":"https://www.wikidata.org/wiki/Q430986","display_name":"Startle response","level":2,"score":0.5293396711349487},{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.5233437418937683},{"id":"https://openalex.org/C103709681","wikidata":"https://www.wikidata.org/wiki/Q1515727","display_name":"Psychopharmacology","level":2,"score":0.5190818309783936},{"id":"https://openalex.org/C137431309","wikidata":"https://www.wikidata.org/wiki/Q1383576","display_name":"Moro reflex","level":3,"score":0.5187451839447021},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4941428005695343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4923902750015259},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4728396534919739},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.41985630989074707},{"id":"https://openalex.org/C50610925","wikidata":"https://www.wikidata.org/wiki/Q1136816","display_name":"Habituation","level":2,"score":0.41844555735588074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3793143928050995},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.30828747153282166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26313281059265137},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.24275130033493042},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.16803941130638123},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11573076248168945},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.09959733486175537},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.07993543148040771}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010622","descriptor_name":"Phencyclidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013216","descriptor_name":"Reflex, Startle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018817","descriptor_name":"N-Methyl-3,4-methylenedioxyamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8955560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8955560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Chinese journal of physiology","raw_type":"Journal Article"},{"id":"mag:69838075","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8955560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1516836592","display_name":"LIMBIC MONOAMINES, BEHAVIOR, AND PSYCHOPATHOLOGY","funder_award_id":"K05MH001223","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2690351138","display_name":"DRUGS OF ABUSE IN SEROTONIN RECEPTORS KNOCKOUT MICE","funder_award_id":"R01DA009862","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2084395458","https://openalex.org/W2334037604","https://openalex.org/W1995878258","https://openalex.org/W2795637533","https://openalex.org/W2005756201","https://openalex.org/W4384664184","https://openalex.org/W2051861971","https://openalex.org/W140954469","https://openalex.org/W2017232056","https://openalex.org/W1491791435"],"abstract_inverted_index":{"The":[0,56],"attenuation":[1],"of":[2,31,52,69,116,135],"the":[3,63,67,125,133],"startle":[4],"response":[5],"termed":[6],"\"prepulse":[7],"inhibition\"":[8],"(PPI)":[9],"occurs":[10],"when":[11],"an":[12],"abrupt":[13],"startling":[14],"stimulus":[15],"is":[16,35,43],"preceded":[17],"30-500":[18],"msec":[19],"by":[20],"a":[21,29,36,50,113],"barely":[22],"detectable":[23],"prestimulus":[24],"or":[25],"\"prepulse\".":[26],"PPI":[27,61,106,117],"provides":[28],"measure":[30],"sensorimotor":[32,136],"gating,":[33],"which":[34],"short":[37],"time-constant":[38],"central":[39],"processing":[40],"mechanism":[41],"that":[42,118,124],"disrupted":[44,90,105],"in":[45,62],"patients":[46],"with":[47,93],"schizophrenia,":[48],"and":[49,65,73,83,86,101],"number":[51],"other":[53],"neuropsychiatric":[54],"disorders.":[55],"present":[57],"experiments":[58],"examined":[59],"normal":[60],"mouse,":[64],"assessed":[66],"effects":[68],"apomorphine,":[70,97],"d-amphetamine,":[71],"PCP,":[72,100],"MDMA":[74,104],"on":[75],"mouse":[76,126],"PPI.":[77,91],"As":[78,92],"predicted,":[79],"mice":[80],"demonstrated":[81],"robust":[82],"reliable":[84],"PPI,":[85],"each":[87],"compound":[88],"tested":[89],"rats,":[94],"2.0":[95],"mg/kg":[96,99,103,110],"10.0":[98,102],"significantly,":[107],"while":[108],"5.0":[109],"d-amphetamine":[111],"produced":[112],"large":[114],"reduction":[115],"approached":[119],"significance.":[120],"Our":[121],"findings":[122],"suggest":[123],"may":[127],"provide":[128],"another":[129],"model":[130],"system":[131],"for":[132],"study":[134],"gating":[137],"mechanisms.":[138]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}