{"id":"https://openalex.org/W6983375501","doi":null,"title":"Mechanisms Underlying the Therapeutic Actions of Psychoplastogens","display_name":"Mechanisms Underlying the Therapeutic Actions of Psychoplastogens","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W6983375501"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt3kf4x7gm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3kf4x7gm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045215746","display_name":"Maxemiliano V. Vargas","orcid":"https://orcid.org/0000-0002-3637-1896","observed_orcids":["https://orcid.org/0000-0002-3637-1896"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vargas, Maxemiliano Vicente","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045215746"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychoplastogens","display_name":"psychoplastogens","score":1.0},{"id":"https://openalex.org/keywords/psychedelics","display_name":"psychedelics","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.7059999704360962},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.9729999899864197},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.550000011920929},{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":0.9980000257492065},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.9980000257492065},{"id":"https://openalex.org/keywords/n-methyltryptamine","display_name":"N-methyltryptamine","score":0.9570000171661377},{"id":"https://openalex.org/keywords/consciousness","display_name":"consciousness","score":0.8190000057220459},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6693000197410583},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5652999877929688},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5077000260353088},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4945000112056732},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.460099995136261},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.43709999322891235},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.3596000075340271},{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.3479999899864197},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3440000116825104},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.31049999594688416},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25850000977516174}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt3kf4x7gm","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3kf4x7gm","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413470543","https://openalex.org/W4321033185","https://openalex.org/W2892307734","https://openalex.org/W3210571302","https://openalex.org/W4323360744","https://openalex.org/W4409143466","https://openalex.org/W4286449579","https://openalex.org/W4387607826","https://openalex.org/W3165796092","https://openalex.org/W4206759226"],"abstract_inverted_index":{"The":[0],"ability":[1],"to":[2,52,57,71,103],"promote":[3,80],"neural":[4,105],"plasticity":[5,81,121],"in":[6,21,101,138,163],"the":[7,11,22,38,45,75,95,114,120,129],"prefrontal":[8],"cortex":[9],"through":[10,77],"use":[12,35],"of":[13,24,40,48,74,97,110,124,131,134],"psychedelics":[14],"and":[15,33,61,82,90,112,153],"other":[16],"psychoplastogens":[17,79],"provides":[18],"immense":[19],"promise":[20],"treatment":[23],"mental":[25],"illnesses":[26],"such":[27],"as":[28],"depression,":[29],"post-traumatic":[30],"stress":[31],"disorder,":[32],"substance":[34],"disorder.":[36],"With":[37],"advent":[39],"these":[41],"new":[42],"therapeutics,":[43],"understanding":[44,130],"underlying":[46],"mechanisms":[47,76,109,133],"action":[49],"becomes":[50],"critical":[51],"ensure":[53],"they":[54],"are":[55],"used":[56],"their":[58],"full":[59],"potential":[60],"future":[62],"psychoplastogen-based":[63],"medicines":[64],"can":[65,146],"be":[66,147],"rationally":[67],"designed.":[68],"We":[69],"sought":[70],"determine":[72],"some":[73],"which":[78],"produce":[83],"therapeutic":[84,151],"behavioral":[85,91],"effects.":[86],"Using":[87],"molecular,":[88],"cellular,":[89],"data":[92],"we":[93],"demonstrated":[94],"importance":[96],"5-HT2A":[98],"subcellular":[99],"localization":[100],"relation":[102],"promoting":[104,122],"plasticity,":[106],"serotonin":[107],"transporter-independent":[108],"R-MDMA,":[111],"how":[113,143,155],"male":[115],"sex":[116],"hormone":[117],"testosterone":[118],"modulates":[119],"properties":[123],"psychoplastogens.":[125],"These":[126],"findings":[127],"further":[128],"psychoplastogen":[132,140],"action,":[135],"have":[136],"implications":[137],"rational":[139],"drug":[141],"design,":[142],"patient":[144],"populations":[145],"stratified":[148],"for":[149],"optimal":[150],"efficacy,":[152],"exploring":[154],"endogenously":[156],"produced":[157],"N-methyltryptamines":[158],"may":[159],"play":[160],"a":[161],"role":[162],"modulating":[164],"consciousness.":[165]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}