{"id":"https://openalex.org/W6982321803","doi":null,"title":"How primordial cells assembled biosynthetic pathways","display_name":"How primordial cells assembled biosynthetic pathways","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W6982321803"},"language":"en","primary_location":{"id":"pmh:oai:flore.unifi.it:2158/402269","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/402269","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"FONDI, MARCO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FONDI, MARCO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016448646","display_name":"Giovanni Emiliani","orcid":"https://orcid.org/0000-0002-1264-8002","observed_orcids":["https://orcid.org/0000-0002-1264-8002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"EMILIANI, GIOVANNI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"FANI, RENATO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FANI, RENATO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50976271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.42989999055862427,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.2354000061750412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.06400000303983688,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/origin-of-metabolism","display_name":"origin of metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/metabolic-pathway-evolution","display_name":"metabolic pathway evolution","score":0.7760000228881836},{"id":"https://openalex.org/keywords/histidine-biosynthesis","display_name":"histidine biosynthesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.9409999847412109},{"id":"https://openalex.org/keywords/genome-evolution","display_name":"genome evolution","score":0.6179999709129333},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.5600000023841858},{"id":"https://openalex.org/keywords/bacteria","display_name":"bacteria","score":0.984000027179718},{"id":"https://openalex.org/keywords/eukarya","display_name":"Eukarya","score":0.8429999947547913},{"id":"https://openalex.org/keywords/biosynthetic-pathway","display_name":"biosynthetic pathway","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6740000247955322},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6588000059127808},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6420999765396118},{"id":"https://openalex.org/C178300618","wikidata":"https://www.wikidata.org/wiki/Q1898509","display_name":"Extant taxon","level":2,"score":0.5536999702453613},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5509999990463257},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.539900004863739},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4341000020503998},{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.41670000553131104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.38940000534057617},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.3749000132083893},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.37229999899864197},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36010000109672546},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.3068999946117401},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.30559998750686646},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3010999858379364},{"id":"https://openalex.org/C10853874","wikidata":"https://www.wikidata.org/wiki/Q180618","display_name":"Genetic code","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C105176652","wikidata":"https://www.wikidata.org/wiki/Q1147112","display_name":"Comparative genomics","level":5,"score":0.26919999718666077},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.2531999945640564},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.2522999942302704},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2402999997138977},{"id":"https://openalex.org/C2908821069","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli Proteins","level":4,"score":0.23929999768733978},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.2214999943971634},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2029999941587448},{"id":"https://openalex.org/C92938381","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Horizontal gene transfer","level":4,"score":0.1973000019788742},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.19699999690055847},{"id":"https://openalex.org/C112212490","wikidata":"https://www.wikidata.org/wiki/Q471134","display_name":"Gene conversion","level":4,"score":0.19499999284744263},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.19449999928474426},{"id":"https://openalex.org/C2910146623","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"DNA Transposable Elements","level":5,"score":0.19349999725818634},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.19040000438690186},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.18690000474452972},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.18490000069141388},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.1843000054359436},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1842000037431717},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.18410000205039978},{"id":"https://openalex.org/C196662502","wikidata":"https://www.wikidata.org/wiki/Q827541","display_name":"Molecular clock","level":4,"score":0.1818999946117401}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:flore.unifi.it:2158/402269","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/402269","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080998949","https://openalex.org/W1974232498","https://openalex.org/W2082922764","https://openalex.org/W2088316404","https://openalex.org/W117808654","https://openalex.org/W2060472039","https://openalex.org/W2165583099","https://openalex.org/W1983947019","https://openalex.org/W4413036452","https://openalex.org/W1997082457"],"abstract_inverted_index":{"The":[0],"emergence":[1],"and":[2,13,32,40,48,58,70,114,122],"evolution":[3,15],"of":[4,25,30,56,61,86,124],"metabolic":[5,63,105,126],"pathways":[6],"represented":[7,133],"a":[8,75],"crucial":[9],"step":[10],"in":[11,91],"molecular":[12,49],"cellular":[14],"allowing":[16],"primitive":[17],"organisms":[18,35],"to":[19,37,82,99,117],"become":[20],"less-dependent":[21],"on":[22,129],"exogenous":[23],"sources":[24],"organic":[26],"compounds.":[27],"Comparative":[28],"analyses":[29],"genes":[31,101],"genomes":[33,57],"from":[34],"belonging":[36],"Archaea,":[38],"Bacteria":[39],"Eukarya":[41],"revealed":[42],"that,":[43,90],"during":[44],"evolution,":[45],"different":[46],"forces":[47],"mechanisms":[50,115],"might":[51,93],"have":[52],"driven":[53],"the":[54,59,83,111,120,130],"shaping":[55],"arisal":[60],"new":[62,87,100,104],"abilities.":[64,106],"Among":[65],"these":[66],"gene":[67,69],"elongations,":[68],"operon":[71],"duplications":[72],"undoubtedly":[73],"played":[74],"major":[76],"role":[77],"since":[78],"they":[79],"can":[80],"lead":[81],"(immediate)":[84],"appearance":[85,121],"genetic":[88],"material":[89],"turn,":[92],"undergo":[94],"evolutionary":[95],"divergence":[96],"giving":[97],"rise":[98],"coding":[102],"for":[103,119],"This":[107],"work":[108],"will":[109],"review":[110],"main":[112],"theories":[113],"proposed":[116],"account":[118],"refinement":[123],"extant":[125],"pathways,":[127],"focusing":[128],"paradigmatic":[131],"study-case":[132],"by":[134],"histidine":[135],"biosynthetic":[136],"route.":[137]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}