{"id":"https://openalex.org/W6982292485","doi":null,"title":"Identification des cibles mol\u00e9culaires de la t\u00e9lomerase dans le rein adulte","display_name":"Identification des cibles mol\u00e9culaires de la t\u00e9lomerase dans le rein adulte","publication_year":2023,"publication_date":"2023-03-28","ids":{"openalex":"https://openalex.org/W6982292485"},"language":"en","primary_location":{"id":"pmh:oai:HAL:tel-04146555v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-04146555","pdf_url":"https://theses.hal.science/tel-04146555v1/file/2023COAZ6008.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human health and pathology. Universit\u00e9 C\u00f4te d'Azur, 2023. English. ⟨NNT : 2023COAZ6008⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-04146555v1/file/2023COAZ6008.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083679462","display_name":"Nicolas Soubeiran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119200","display_name":"Institut de Recherche sur le Cancer et le Vieillissement de Nice","ror":"https://ror.org/01td3kv81","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210119200"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Soubeiran, Nicolas","raw_affiliation_strings":["Institut de Recherche sur le Cancer et le Vieillissement"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherche sur le Cancer et le Vieillissement","institution_ids":["https://openalex.org/I4210119200"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083679462"],"corresponding_institution_ids":["https://openalex.org/I4210119200"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9079999923706055},{"id":"https://openalex.org/keywords/renal-epithelial-cells","display_name":"renal epithelial cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8149999976158142},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9070000052452087},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7879999876022339},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8579999804496765},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8342999815940857},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6744999885559082},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6471999883651733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6279000043869019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5504000186920166},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.4832000136375427},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.44369998574256897},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4203000068664551},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.4049000144004822},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39089998602867126},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.37549999356269836},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.353300005197525},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31049999594688416},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C138798377","wikidata":"https://www.wikidata.org/wiki/Q7312502","display_name":"Renal stem cell","level":4,"score":0.27469998598098755},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25949999690055847},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:tel-04146555v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-04146555","pdf_url":"https://theses.hal.science/tel-04146555v1/file/2023COAZ6008.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human health and pathology. Universit\u00e9 C\u00f4te d'Azur, 2023. English. ⟨NNT : 2023COAZ6008⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:HAL:tel-04146555v1","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-04146555","pdf_url":"https://theses.hal.science/tel-04146555v1/file/2023COAZ6008.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human health and pathology. Universit\u00e9 C\u00f4te d'Azur, 2023. English. ⟨NNT : 2023COAZ6008⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5256916880607605}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6982292485.pdf","grobid_xml":"https://content.openalex.org/works/W6982292485.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Telomerase":[0],"exhibits":[1],"non-canonical":[2,28,265],"functions":[3,184,220,247,266,278],"that":[4,90,119,170,190,233,254],"play":[5],"key":[6],"roles":[7],"in":[8,40,74,148,154,159,185,215,227,242,261,267,279],"both":[9],"progenitor":[10],"and":[11,52,108,133,158,269],"cancer":[12],"cells.":[13,201],"In":[14,78,113,140],"the":[15,18,34,44,61,71,122,136,149,176,193,211,216,237,243,255,274,284],"adult":[16,19,41,155],"organism,":[17],"mammalian":[20],"kidney":[21,47,72,87,150,165,199,224,249,280],"shows":[22],"a":[23,258],"high":[24],"sensitivity":[25],"to":[26,57,69,103,197],"telomerase":[27,38,183,264],"functions.":[29],"Thus,":[30],"conditional":[31],"overexpression":[32],"of":[33,37,46,67,110,121,146,163,179,182,195,218,223,236,245,263,276,286],"protein":[35],"component":[36],"TERT":[39,68,128,152,171,196,219,246],"mice":[42,187],"triggers":[43],"reprogramming":[45,130],"epithelial":[48,88,166,200,250],"cells":[49,89],"into":[50],"dedifferentiated":[51],"proliferating":[53],"cells,":[54,167],"ultimately":[55],"leading":[56],"renal":[58],"failure.":[59],"However,":[60],"molecular":[62,212],"mechanisms":[63,213],"underlying":[64],"this":[65,79],"ability":[66,194],"reprogram":[70,198],"epithelium":[73],"vivo":[75],"remain":[76],"unknown.":[77],"study,":[80],"we":[81,168],"performed":[82],"high-throughput":[83],"sequencing":[84,203],"on":[85,207,248],"TERT-activated":[86],"have":[91],"been":[92],"FACS":[93],"sorted":[94],"along":[95],"their":[96],"cellular":[97],"reprogramming.":[98,112,180],"This":[99],"approach":[100],"allowed":[101],"us":[102],"identify":[104],"potential":[105],"master":[106],"regulators":[107],"effectors":[109],"TERT-induced":[111],"addition,":[114],"pathway":[115],"analysis":[116,142],"unexpectedly":[117],"showed":[118,144],"one":[120],"first":[123],"signaling":[124],"pathways":[125],"targeted":[126],"by":[127],"during":[129,175],"involves":[131],"remodeling":[132,145],"interaction":[134],"with":[135,283],"extracellular":[137],"matrix":[138],"(ECM).":[139],"situ":[141],"further":[143,188],"ECM":[147,256],"upon":[151,221],"induction":[153],"mice.":[156],"Using":[157],"vitro":[160,228],"culture":[161,230],"system":[162],"primary":[164],"found":[169],"promotes":[172],"cell":[173],"adhesion":[174],"initial":[177],"step":[178],"Assessment":[181],"aged":[186,208],"revealed":[189,232],"aging":[191,222],"restrains":[192],"High-throughput":[202],"approaches":[204],"carried":[205],"out":[206],"animals":[209],"highlighted":[210],"involved":[214,241],"impairment":[217],"epithelium.":[225],"Finally,":[226],"Hydrogel-based":[229],"systems":[231],"age-associated":[234],"stiffness":[235],"microenvironment":[238],"is":[239],"not":[240],"repression":[244],"cells.Our":[251],"findings":[252],"demonstrate":[253],"plays":[257],"crucial":[259],"role":[260],"implementation":[262],"vivo,":[268],"open":[270],"new":[271],"perspectives":[272],"for":[273],"modulation":[275],"these":[277],"diseases":[281],"associated":[282],"upregulation":[285],"telomerase.":[287]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-09-25T00:00:00"}