{"id":"https://openalex.org/W6982068337","doi":null,"title":"Glutamine deficiency in driving cancer development and modulating therapeutic response","display_name":"Glutamine deficiency in driving cancer development and modulating therapeutic response","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W6982068337"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt1zd6526c","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1zd6526c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002364141","display_name":"Thai Q. Tran","orcid":"https://orcid.org/0000-0001-7559-0525","observed_orcids":["https://orcid.org/0000-0001-7559-0525"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tran, Thai Quan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5002364141"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutamine-deficiency","display_name":"glutamine deficiency","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.753000020980835},{"id":"https://openalex.org/keywords/glutamine-addiction","display_name":"glutamine addiction","score":0.828000009059906},{"id":"https://openalex.org/keywords/mutant-p53","display_name":"mutant p53","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dna-alkylation","display_name":"DNA alkylation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/alkylating-agents","display_name":"alkylating agents","score":0.9070000052452087},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.734000027179718},{"id":"https://openalex.org/keywords/drug-response","display_name":"drug response","score":0.4880000054836273},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.8457000255584717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5737000107765198},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5605000257492065},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5442000031471252},{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.5313000082969666},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5275999903678894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5170000195503235},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5076000094413757},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.448199987411499},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.4230000078678131},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C156902634","wikidata":"https://www.wikidata.org/wiki/Q5058346","display_name":"Cellular adaptation","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.26820001006126404},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.2556000053882599},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt1zd6526c","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/1zd6526c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3021389012","https://openalex.org/W2399959306","https://openalex.org/W2767744632","https://openalex.org/W2503851771","https://openalex.org/W4323359343","https://openalex.org/W2531816667","https://openalex.org/W4210593125","https://openalex.org/W2891670030","https://openalex.org/W2608465247","https://openalex.org/W2810207279"],"abstract_inverted_index":{"Metabolic":[0],"reprogramming":[1],"is":[2,103,287],"a":[3,194,288],"hallmark":[4],"of":[5,34,85,108,127,178,206,240,248,267,291,306,321],"cancer":[6,35,113,162,277,315,327],"that":[7,47,77,190,281],"plays":[8,193],"an":[9,55,246],"essential":[10],"role":[11,23,57,98,177,196],"in":[12,24,51,58,100,134,156,161,167,182,197,297,313,325,343],"tumor":[13,73,101],"initiation":[14],"and":[15,28,61,68,115,146,163,222,252,275,294,317,340,353],"progression.":[16],"Glutamine":[17],"metabolism,":[18,26],"due":[19],"to":[20,40,89,185,200,245,257],"its":[21],"diverse":[22],"central":[25],"signaling":[27,273,293],"epigenetics,":[29],"has":[30],"become":[31],"the":[32,41,48,72,90,97,106,158,176,204,217,236,241,265,303,310,318,336],"forefront":[33],"metabolism":[36,221,269,339],"research.":[37],"In":[38],"addition":[39],"Warburg\u2019s":[42],"effect,":[43],"emerging":[44],"evidence":[45],"reveals":[46],"\u201cglutamine":[49],"addiction\u201d":[50],"human":[52],"tumors":[53,80],"play":[54],"important":[56],"both":[59],"tumorigenesis":[60],"therapeutic":[62,116,319],"response.":[63,148],"With":[64],"enhanced":[65],"glutamine":[66,86,110,128,159,169,186,201,220,233,268,307],"uptake":[67],"poor":[69],"vascularization":[70],"at":[71],"sites,":[74],"it":[75],"appears":[76],"most":[78],"solid":[79],"will":[81,123,346],"experience":[82],"some":[83],"degree":[84],"deficiency":[87,111,129,234],"similar":[88],"low":[91],"oxygen":[92],"conditions":[93],"or":[94],"hypoxia.":[95],"While":[96],"hypoxia":[99],"biology":[102],"well":[104],"established,":[105],"impact":[107,305],"intratumoral":[109],"on":[112,130,270,309,335],"progression":[114,316],"response":[117,140,184],"remains":[118],"largely":[119],"unknown.":[120],"This":[121],"dissertation":[122],"explore":[124,302],"potential":[125,304,320],"effects":[126],"various":[131],"cellular":[132,183,198,255,295],"processes":[133],"malignant":[135],"cells":[136],"including":[137],"DNA":[138,223,237,249],"damage":[139,224,251],"pathway,":[141],"epigenetic":[142,285,341],"reprogramming,":[143],"oncogenic":[144,271],"signaling,":[145],"drug":[147],"\\tIn":[149,171,260],"chapter":[150,172,213,261,329],"1,":[151],"I":[152,331,345],"summarize":[153],"recent":[154,333],"progress":[155,334],"understanding":[157],"addiction":[160],"highlight":[164],"clinical":[165,354],"opportunities":[166],"targeting":[168],"metabolism.":[170],"2,":[173],"we":[174,215,263],"investigate":[175],"tumor-associated":[179],"mutant":[180,191],"p53":[181,192],"deprivation.":[187],"We":[188,227,279,300],"demonstrate":[189],"major":[195],"adaptation":[199],"deprivation":[202],"through":[203,284],"upregulation":[205],"pro-survival":[207],"genes":[208],"but":[209],"not":[210],"pro-death":[211],"genes.\\tIn":[212],"3,":[214],"examine":[216],"crosstalk":[218,337],"between":[219,338],"repair":[225,238],"pathway.":[226],"provide":[228],"mechanistic":[229],"insights":[230],"by":[231],"which":[232],"inhibits":[235],"activity":[239],"ALKBH":[242],"enzymes,":[243],"leading":[244],"accumulation":[247],"alkylation":[250],"thereby":[253],"increasing":[254],"sensitivity":[256],"alkylating":[258],"agents.":[259],"4,":[262],"study":[264],"effect":[266],"Wnt":[272,292],"pathway":[274],"colorectal":[276],"development.":[278],"reveal":[280],"glutamine/alpha-ketoglutarate":[282],"axis":[283],"modulations":[286],"critical":[289],"regulator":[290],"differentiation":[296],"colon":[298,314,326],"cancer.":[299,344],"further":[301,347],"starvation":[308],"adeno-carcinoma":[311],"transition":[312],"alpha":[322],"ketoglutarate":[323],"supplementation":[324],"treatment.\\tIn":[328],"5,":[330],"discuss":[332,348],"regulation":[342],"remaining":[349],"questions,":[350],"future":[351],"directions":[352],"implications":[355],"derived":[356],"from":[357],"these":[358],"findings.":[359]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
