{"id":"https://openalex.org/W6981985828","doi":null,"title":"Genetic approaches for the assessment of the causality of maternal exposures","display_name":"Genetic approaches for the assessment of the causality of maternal exposures","publication_year":2024,"publication_date":"2024-09-18","ids":{"openalex":"https://openalex.org/W6981985828"},"language":"en","primary_location":{"id":"pmh:oai:aaltodoc.aalto.fi:123456789/131025","doi":null,"is_oa":false,"landing_page_url":"https://aaltodoc.aalto.fi/bitstreams/a5426a6d-eee5-4be4-844e-78e31c0b14e2/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401662","display_name":"Aaltodoc (Aalto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I9927081","host_organization_name":"Aalto University","host_organization_lineage":["https://openalex.org/I9927081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"G1 Kandidaatinty\u00f6"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lehto, Elias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lehto, Elias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-exposure","display_name":"maternal exposure","score":0.859000027179718},{"id":"https://openalex.org/keywords/causality-assessment","display_name":"causality assessment","score":0.7689999938011169},{"id":"https://openalex.org/keywords/mendelian-randomization","display_name":"Mendelian randomization","score":0.9160000085830688},{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/child-health-outcomes","display_name":"child health outcomes","score":0.5730000138282776},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.48899999260902405},{"id":"https://openalex.org/keywords/finngen","display_name":"FinnGen","score":0.6650000214576721},{"id":"https://openalex.org/keywords/genetic-epidemiology","display_name":"genetic epidemiology","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.9050999879837036},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.9017000198364258},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6596999764442444},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44130000472068787},{"id":"https://openalex.org/C11671645","wikidata":"https://www.wikidata.org/wiki/Q5054567","display_name":"Causal model","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4090999960899353},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40070000290870667},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.3783999979496002},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3646000027656555},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.3483999967575073},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C95713431","wikidata":"https://www.wikidata.org/wiki/Q631425","display_name":"Vulnerability (computing)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C115086926","wikidata":"https://www.wikidata.org/wiki/Q17004651","display_name":"Causal reasoning","level":3,"score":0.3154999911785126},{"id":"https://openalex.org/C180838311","wikidata":"https://www.wikidata.org/wiki/Q3720208","display_name":"Maternal effect","level":4,"score":0.2930999994277954},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C185874996","wikidata":"https://www.wikidata.org/wiki/Q269699","display_name":"Interdependence","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C2987525970","wikidata":"https://www.wikidata.org/wiki/Q96374569","display_name":"Causal analysis","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2983493262","wikidata":"https://www.wikidata.org/wiki/Q6786626","display_name":"Maternal health","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.25029999017715454}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:aaltodoc.aalto.fi:123456789/131025","doi":null,"is_oa":false,"landing_page_url":"https://aaltodoc.aalto.fi/bitstreams/a5426a6d-eee5-4be4-844e-78e31c0b14e2/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306401662","display_name":"Aaltodoc (Aalto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I9927081","host_organization_name":"Aalto University","host_organization_lineage":["https://openalex.org/I9927081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"G1 Kandidaatinty\u00f6"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2920064621","https://openalex.org/W2589130925","https://openalex.org/W7053430333","https://openalex.org/W7135993707","https://openalex.org/W3048876172","https://openalex.org/W3020885053","https://openalex.org/W2884808273","https://openalex.org/W3158798301","https://openalex.org/W4411259687","https://openalex.org/W7134832053"],"abstract_inverted_index":{"As":[0],"suggested":[1],"by":[2],"the":[3,20,29,37,56,69,72,85,88,104,124],"Theory":[4],"of":[5,8,23,32,39,58,71,74,106,122,126],"Developmental":[6],"Origins":[7],"Health":[9],"and":[10,52,61,96],"Disease":[11],"(DO-HaD),":[12],"maternal":[13,40,107,127],"exposures":[14,41,76,128],"can":[15,45,66,99],"have":[16],"an":[17],"impact":[18],"on":[19],"lifelong":[21],"health":[22],"a":[24,93,119],"child":[25,43],"through":[26,92],"influences":[27],"during":[28],"developmental":[30],"phases":[31],"their":[33],"life.":[34],"Thus,":[35],"elucidating":[36],"causality":[38,73,105,125],"onto":[42],"outcomes":[44],"give":[46],"new":[47],"insights":[48],"into":[49],"different":[50],"diseases":[51],"be":[53,100],"helpful":[54],"in":[55,112,129],"treatment":[57],"them":[59],"before":[60],"after":[62],"birth.":[63],"Genetic":[64],"analyses":[65],"potentially":[67],"allow":[68],"assessment":[70],"these":[75],"better":[77],"than":[78],"traditional":[79],"observational":[80],"studies.":[81],"This":[82],"paper":[83],"introduces":[84],"reader":[86],"to":[87,102,118],"concept":[89],"Mendelian":[90],"randomization":[91],"literature":[94],"review":[95],"how":[97],"it":[98],"used":[101],"assess":[103],"exposures.":[108],"The":[109],"concepts":[110],"presented":[111],"this":[113],"thesis":[114],"are":[115],"then":[116],"applied":[117],"use":[120],"case":[121],"assessing":[123],"FinnGen":[130],"Release":[131],"12.":[132]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2025-10-10T00:00:00"}