{"id":"https://openalex.org/W6981353087","doi":null,"title":"The Effects of Parental Ethanol Exposure on Offspring Development","display_name":"The Effects of Parental Ethanol Exposure on Offspring Development","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W6981353087"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt2j95p98c","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2j95p98c","pdf_url":"https://escholarship.org/content/qt2j95p98c/qt2j95p98c.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/content/qt2j95p98c/qt2j95p98c.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045361820","display_name":"Kathleen E. Conner","orcid":"https://orcid.org/0000-0002-0471-9907","observed_orcids":["https://orcid.org/0000-0002-0471-9907"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Conner, Kathleen Elizabeth","raw_affiliation_strings":["Doctor of Philosophy , Graduate Program in Neuroscience University of California , Riverside , June 2024"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctor of Philosophy , Graduate Program in Neuroscience University of California , Riverside , June 2024","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045361820"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-alcohol-exposure","display_name":"prenatal alcohol exposure","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.9369999766349792},{"id":"https://openalex.org/keywords/transgenerational-effects","display_name":"transgenerational effects","score":0.9279999732971191},{"id":"https://openalex.org/keywords/offspring-neurodevelopment","display_name":"offspring neurodevelopment","score":0.6959999799728394},{"id":"https://openalex.org/keywords/craniofacial-abnormalities","display_name":"craniofacial anomalies","score":0.9089999794960022},{"id":"https://openalex.org/keywords/agenesis-of-the-corpus-callosum","display_name":"agenesis of the corpus callosum","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sensorimotor-integration","display_name":"sensorimotor integration","score":0.8009999990463257},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sex-specific-effects","display_name":"sex-specific effects","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.9254000186920166},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.6721000075340271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5435000061988831},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5188999772071838},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.4733000099658966},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.45080000162124634},{"id":"https://openalex.org/C2984223407","wikidata":"https://www.wikidata.org/wiki/Q1345738","display_name":"Brain development","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4034000039100647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3815000057220459},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.3741999864578247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3693999946117401},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.36890000104904175},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.34299999475479126},{"id":"https://openalex.org/C2780787877","wikidata":"https://www.wikidata.org/wiki/Q1135124","display_name":"Agenesis of the corpus callosum","level":3,"score":0.3357999920845032},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3296000063419342},{"id":"https://openalex.org/C3018923374","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Prenatal exposure","level":4,"score":0.31619998812675476},{"id":"https://openalex.org/C2909481879","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Prenatal alcohol exposure","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C180838311","wikidata":"https://www.wikidata.org/wiki/Q3720208","display_name":"Maternal effect","level":4,"score":0.28790000081062317},{"id":"https://openalex.org/C2777601104","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Fetal alcohol syndrome","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C3020575016","wikidata":"https://www.wikidata.org/wiki/Q400277","display_name":"Fetal alcohol","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.26170000433921814}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:escholarship.org:ark:/13030/qt2j95p98c","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2j95p98c","pdf_url":"https://escholarship.org/content/qt2j95p98c/qt2j95p98c.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"}],"best_oa_location":{"id":"pmh:oai:escholarship.org:ark:/13030/qt2j95p98c","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2j95p98c","pdf_url":"https://escholarship.org/content/qt2j95p98c/qt2j95p98c.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6981353087.pdf","grobid_xml":"https://content.openalex.org/works/W6981353087.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1410297322","https://openalex.org/W1511675216","https://openalex.org/W1549719654","https://openalex.org/W1570708643","https://openalex.org/W1613085441","https://openalex.org/W1854617428","https://openalex.org/W1902693905","https://openalex.org/W1951724000","https://openalex.org/W1968899084","https://openalex.org/W1969703003","https://openalex.org/W1970874194","https://openalex.org/W1973386992","https://openalex.org/W1974651731","https://openalex.org/W1980918115","https://openalex.org/W1982062551","https://openalex.org/W1982278227","https://openalex.org/W1987205085","https://openalex.org/W1992213480","https://openalex.org/W1994590240","https://openalex.org/W1997860363","https://openalex.org/W2007023810","https://openalex.org/W2008106418","https://openalex.org/W2010570871","https://openalex.org/W2012330620","https://openalex.org/W2012757283","https://openalex.org/W2020184819","https://openalex.org/W2020800024","https://openalex.org/W2034798927","https://openalex.org/W2043062172","https://openalex.org/W2044018978","https://openalex.org/W2045880771","https://openalex.org/W2053546801","https://openalex.org/W2057828011","https://openalex.org/W2062403124","https://openalex.org/W2064999507","https://openalex.org/W2066371075","https://openalex.org/W2067381654","https://openalex.org/W2069780367","https://openalex.org/W2070515192","https://openalex.org/W2073749890","https://openalex.org/W2074962306","https://openalex.org/W2076173032","https://openalex.org/W2079124438","https://openalex.org/W2081247087","https://openalex.org/W2095736054","https://openalex.org/W2096083625","https://openalex.org/W2099455560","https://openalex.org/W2106537812","https://openalex.org/W2107408814","https://openalex.org/W2112834092","https://openalex.org/W2116599270","https://openalex.org/W2133944759","https://openalex.org/W2136801368","https://openalex.org/W2137505881","https://openalex.org/W2140536312","https://openalex.org/W2141549067","https://openalex.org/W2144505094","https://openalex.org/W2150230875","https://openalex.org/W2162665706","https://openalex.org/W2164760908","https://openalex.org/W2173670840","https://openalex.org/W2222884808","https://openalex.org/W2268683216","https://openalex.org/W2275293999","https://openalex.org/W2300274411","https://openalex.org/W2510449525","https://openalex.org/W2519362014","https://openalex.org/W2563252357","https://openalex.org/W2589060457","https://openalex.org/W2596798372","https://openalex.org/W2622695354","https://openalex.org/W2732741185","https://openalex.org/W2743807044","https://openalex.org/W2744626483","https://openalex.org/W2754348497","https://openalex.org/W2792288381","https://openalex.org/W2794343169","https://openalex.org/W2811212358","https://openalex.org/W2889100538","https://openalex.org/W2898382534","https://openalex.org/W2908902689","https://openalex.org/W2912214838","https://openalex.org/W2939851233","https://openalex.org/W2946874690","https://openalex.org/W2949455684","https://openalex.org/W2954451446","https://openalex.org/W2990710842","https://openalex.org/W2996008853","https://openalex.org/W3004430113","https://openalex.org/W3028010113","https://openalex.org/W3028573251","https://openalex.org/W3031666617","https://openalex.org/W3035782573","https://openalex.org/W3042746253","https://openalex.org/W3119898158","https://openalex.org/W3167989184","https://openalex.org/W3187256999","https://openalex.org/W3191683967","https://openalex.org/W4205519793","https://openalex.org/W4206687755","https://openalex.org/W4211070872","https://openalex.org/W4220785512","https://openalex.org/W4237261732","https://openalex.org/W4283513112","https://openalex.org/W4289528024","https://openalex.org/W4309741848","https://openalex.org/W4390952925"],"related_works":["https://openalex.org/W7140141166","https://openalex.org/W7028819924","https://openalex.org/W4220785512","https://openalex.org/W7056536728","https://openalex.org/W2767966454","https://openalex.org/W2990710842","https://openalex.org/W2588501279","https://openalex.org/W2207130216","https://openalex.org/W2732741185","https://openalex.org/W2889972747"],"abstract_inverted_index":{"Fetal":[0],"alcohol":[1,18,316,343],"spectrum":[2],"disorders":[3],"(FASD)":[4],"describe":[5],"the":[6,64,105,132,198,202,230,238,280,285,306,312,336],"wide":[7],"array":[8],"of":[9,33,123,146,180,192,197,204,241,266,271,314],"long-lasting":[10],"developmental":[11],"abnormalities":[12],"in":[13,48,68,110,131,141,166,177,188,201,213,264,279,335],"offspring":[14,65,247,296,337],"due":[15],"to":[16,46,85,104,159,168,184,227,302,321],"prenatal":[17,34],"(ethanol":[19],"[EtOH])":[20],"exposure":[21,36,43,244],"via":[22],"maternal":[23],"gestational":[24],"drinking.":[25],"Our":[26,52],"laboratory":[27],"has":[28],"identified":[29],"many":[30],"deleterious":[31],"effects":[32,62,122,240,294,313,332],"ethanol":[35,42],"(PrEE)":[37],"as":[38,40,99,101,330],"well":[39,100],"paternal":[41,242],"(PatEE)":[44,245],"prior":[45,320],"conception":[47,322],"a":[49,189,208],"mouse":[50],"model.":[51],"results":[53],"indicate":[54],"that":[55,81,298,311],"PrEE":[56,82,147,181,186],"and":[57,74,91,96,107,128,137,155,215,223,249,258,261,273],"PatEE":[58,259,290],"can":[59,83,299],"have":[60],"substantial":[61],"on":[63,246,295],"including":[66],"alterations":[67],"gross":[69],"anatomy,":[70],"neuroanatomy,":[71],"gene":[72,275],"expression,":[73],"behavior.":[75],"In":[76],"chapter":[77],"1,":[78],"we":[79,125,236],"show":[80],"lead":[84],"craniofacial":[86],"anomalies,":[87],"decreased":[88,93,150],"body":[89,151,169],"weight":[90,95,170],"length,":[92,98],"brain":[94,127,153,167,248],"cortical":[97],"structural":[102],"changes":[103],"cortex":[106],"corpus":[108,199],"callosum":[109,200],"embryonic":[111],"development":[112,130,196],"(E12.5,":[113],"E14.5,":[114],"E16.5,":[115],"E18.5).":[116],"To":[117],"further":[118],"explore":[119],"potential":[120],"heritable":[121],"PrEE,":[124],"investigated":[126,237],"behavioral":[129,250],"F1":[133,205,281],"(directly-exposed),":[134],"F2":[135,214,231,286],"(indirectly-exposed)":[136],"F3":[138,216],"(non-exposed)":[139],"generations":[140,145,179,304],"Chapter":[142,234],"2.":[143],"All":[144],"newborns":[148],"had":[149],"weights,":[152,154],"neocortical":[156,267],"lengths":[157],"compared":[158,183],"controls,":[160],"although":[161],"there":[162],"were":[163,277,333],"no":[164,254],"differences":[165,255],"ratios.":[171],"Hippocampal":[172],"CA3":[173],"was":[174],"significantly":[175],"thinner":[176],"all":[178],"mice":[182,263],"controls.":[185],"resulted":[187],"significant":[190],"rate":[191],"agenesis":[193],"or":[194,319],"partial":[195],"majority":[203],"cases,":[206],"with":[207],"less":[209],"frequent,":[210],"non-significant,":[211],"occurrence":[212],"mice.":[217],"Disrupted":[218],"sensorimotor":[219],"integration,":[220],"motor":[221],"control,":[222],"anxiety-like":[224],"behavior":[225,297],"persisted":[226],"at":[228,287],"least":[229],"generation.":[232],"\\nIn":[233],"3,":[235],"transgenerational":[239,331],"EtOH":[243],"development.":[251],"We":[252],"observed":[253,278,334],"between":[256],"control":[257],"(F1":[260],"F2)":[262],"measures":[265],"length.":[268],"Abnormal":[269],"patterns":[270],"Id2":[272],"RZR\u03b2":[274],"expression":[276],"generation":[282],"but":[283],"not":[284],"P0.":[288],"Additionally,":[289],"may":[291,323],"generate":[292],"sex-specific":[293],"last":[300],"up":[301],"two":[303],"after":[305],"sire\u2019s":[307],"initial":[308],"exposure.\\nWe":[309],"propose":[310],"drinking":[315],"during":[317],"pregnancy":[318],"be":[324],"more":[325],"serious":[326],"than":[327],"previously":[328],"thought":[329],"even":[338],"though":[339],"they":[340],"never":[341],"consumed":[342],"themselves.":[344]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
