{"id":"https://openalex.org/W6980585488","doi":null,"title":"CHRONIC ETHANOL EXPOSURE INDUCES NEUROPATHIC PAIN IN MICE BY PROMOTING NEUROINFLAMMATION","display_name":"CHRONIC ETHANOL EXPOSURE INDUCES NEUROPATHIC PAIN IN MICE BY PROMOTING NEUROINFLAMMATION","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W6980585488"},"language":"en","primary_location":{"id":"pmh:oai:flore.unifi.it:2158/1281447","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1281447","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2158/1281447","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083363054","display_name":"Vittoria Borgonetti","orcid":"https://orcid.org/0000-0002-2203-5285","observed_orcids":["https://orcid.org/0000-0002-2203-5285"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vittoria Borgonetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amanda Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079449507","display_name":"Nicoletta Galeotti","orcid":"https://orcid.org/0000-0002-1812-9844","observed_orcids":["https://orcid.org/0000-0002-1812-9844"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoletta Galeotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060479945","display_name":"Marisa Roberto","orcid":"https://orcid.org/0000-0003-0729-3961","observed_orcids":["https://orcid.org/0000-0003-0729-3961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marisa Roberto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-alcohol-exposure","display_name":"chronic ethanol exposure","score":0.8180000185966492},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8740000128746033},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.8489999771118164},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.8920000195503235},{"id":"https://openalex.org/keywords/two-bottle-choice","display_name":"two-bottle choice","score":0.6299999952316284},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.7160000205039978},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6679999828338623},{"id":"https://openalex.org/keywords/alcohol-reinforcement","display_name":"alcohol reinforcement","score":0.4690000116825104},{"id":"https://openalex.org/keywords/negative-reinforcement","display_name":"negative reinforcement","score":0.6320000290870667},{"id":"https://openalex.org/keywords/vapor-exposure","display_name":"vapor exposure","score":0.4429999887943268},{"id":"https://openalex.org/keywords/alcohol-related-neuropathy","display_name":"alcohol-related neuropathy","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8544999957084656},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.7982000112533569},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6897000074386597},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.6237999796867371},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5525000095367432},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5418999791145325},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5414000153541565},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5085999965667725},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4399999976158142},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40639999508857727},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.4023999869823456},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.3693000078201294},{"id":"https://openalex.org/C3019635848","wikidata":"https://www.wikidata.org/wiki/Q154","display_name":"Alcohol consumption","level":3,"score":0.32989999651908875},{"id":"https://openalex.org/C3017738346","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Chronic alcoholism","level":2,"score":0.3172000050544739},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C3673659","wikidata":"https://www.wikidata.org/wiki/Q1098125","display_name":"Threshold of pain","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.2912999987602234},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2782000005245209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2702000141143799},{"id":"https://openalex.org/C3018430727","wikidata":"https://www.wikidata.org/wiki/Q11058472","display_name":"Alcohol intake","level":3,"score":0.25769999623298645}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:flore.unifi.it:2158/1281447","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1281447","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:usiena-air.unisi.it:11365/1289082","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11365/1289082","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":{"id":"pmh:oai:flore.unifi.it:2158/1281447","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2158/1281447","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4365443722","https://openalex.org/W4414043687","https://openalex.org/W4409867314","https://openalex.org/W2955684080","https://openalex.org/W7140220732","https://openalex.org/W4288069989","https://openalex.org/W4231802924","https://openalex.org/W6889692200","https://openalex.org/W2977007813","https://openalex.org/W4409142121"],"abstract_inverted_index":{"ACKGROUND:":[0],"Alcohol":[1],"use":[2],"disorder":[3],"(AUD)":[4],"is":[5,29,57,66],"defined":[6],"by":[7,265],"the":[8,42,76,83,91,105,116,144,164,174,207,232,247,258,275,327,332,348,359],"emergence":[9],"of":[10,45,78,85,93,99,107,177,188,196,235,254,270,279,318,335,350,361],"negative":[11,32],"affective":[12],"symptoms":[13],"during":[14,173,231],"withdrawal.":[15],"In":[16,185],"particular,":[17],"chronic":[18,46,50,111,288,333,363],"or":[19],"excessive":[20],"alcohol":[21,51,62,100,133,289,336],"consumption":[22,52,334],"results":[23,285],"in":[24,75,95,109,132,167,192,206,212,274,294,305,314,346],"a":[25,31,58,71,96,226,251,340],"hypersensitivity":[26,312],"condition,":[27],"that":[28,287,310,331],"considered":[30],"reinforcement":[33,63],"process,":[34],"facilitating":[35],"AUD":[36],"progression.":[37],"The":[38],"mechanisms":[39],"responsible":[40],"for":[41,358],"observed":[43,211,309],"increasing":[44],"pain":[47,364],"associated":[48],"with":[49,143],"are":[53],"still":[54],"unknown.":[55],"Neuroinflammation":[56],"key":[59,72],"contributor":[60],"to":[61,69,89,103,125,162,216,257,299,326],"and":[64,102,151,170,179,221,301,316,321,345],"it":[65],"well":[67],"known":[68],"play":[70],"role":[73,106,349],"also":[74,199,338],"pathogenesis":[77],"neuropath-":[79],"ic":[80],"pain.":[81],"Thus,":[82],"aim":[84],"this":[86,110,362],"project":[87],"was":[88,210,238,262],"evaluate":[90],"development":[92],"neuropathy":[94],"mouse":[97],"model":[98,307],"dependence,":[101],"investigate":[104],"neuroinflammation":[108],"condition.":[112,365],"METHODS:":[113],"We":[114],"used":[115,161],"chronic-intermit-":[117],"tent":[118],"ethanol":[119],"two-bottle":[120],"choice":[121,183],"(2BC-CIE)":[122],"par-":[123],"adigm":[124],"generate":[126],"ethanol-dependent":[127],"(Dep)":[128],"mice":[129,142,172,197,224],"exhibiting":[130],"escalations":[131],"drink-":[134],"ing":[135],"after":[136,181,242],"CIE":[137],"vapor":[138],"exposure,":[139],"non-dependent":[140],"(Non-Dep)":[141],"same":[145],"voluntary":[146,243],"alco-":[147],"hol":[148],"drinking":[149,204],"history":[150],"ethanol-naive":[152],"(naive)":[153],"control":[154],"C57bl/6J":[155],"mice.":[156,218,303],"Von":[157],"Frey":[158],"filaments":[159],"were":[160,198,281],"measure":[163],"mechanical":[165],"allodynia":[166,230],"naive,":[168],"Non-Dep":[169,217,248,300],"Dep":[171,208,223,295,319],"72":[175,233],"h":[176,234],"withdrawal":[178],"immediately":[180,241],"2-bottle":[182],"test.":[184,245],"vitro":[186],"evaluations":[187],"microglia":[189,271,351],"ac-":[190],"tivation":[191],"spinal":[193,276],"cord":[194,277],"tissue":[195,278],"conducted.":[200],"RESULTS:":[201],"A":[202],"significant":[203],"escalation":[205],"group":[209,249],"both":[213],"sexes,":[214],"compared":[215,256,325],"Both":[219],"male":[220,320],"female":[222,322],"developed":[225],"strong":[227],"mechan-":[228],"ical":[229],"withdrawal,":[236],"which":[237,261],"completely":[239],"reverted":[240,264],"2BC":[244],"Also,":[246],"showed":[250],"long-lasting":[252],"increase":[253,269],"sensitivity":[255],"naive":[259,302,328],"group,":[260,329],"not":[263],"self-alcohol":[266],"administration.":[267],"An":[268],"activation":[272],"markers":[273],"2BC-CIE":[280],"observed.":[282],"CONCLUSIONS:":[283],"These":[284],"suggested":[286],"exposure":[290],"induced":[291],"abstinencerelated":[292],"hyperalgesia":[293],"mice,":[296,323],"com-":[297],"pared":[298],"Moreover,":[304],"our":[306],"we":[308],"increased":[311],"occurs":[313],"40%":[315],"50%":[317],"respectively,":[324],"highlighting":[330],"may":[337,353],"induces":[339],"direct":[341],"alcohol-related":[342],"neuropathy.":[343],"Neuroinflammation,":[344],"particular":[347],"activation,":[352],"represent":[354],"an":[355],"interesting":[356],"target":[357],"management":[360]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}