{"id":"https://openalex.org/W6980147995","doi":null,"title":"Avalia\u00e7\u00e3o dos efeitos da exposi\u00e7\u00e3o ao LDL-colesterol em linhagem de c\u00e9lulas microgliais","display_name":"Avalia\u00e7\u00e3o dos efeitos da exposi\u00e7\u00e3o ao LDL-colesterol em linhagem de c\u00e9lulas microgliais","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W6980147995"},"language":"pt","primary_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/276748","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/276748","pdf_url":"https://lume.ufrgs.br/bitstream/10183/276748/1/001206092.pdf","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Disserta\u00e7\u00e3o"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lume.ufrgs.br/bitstream/10183/276748/1/001206092.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020027021","display_name":"S\u00e1mili Wagner da Silva","orcid":"https://orcid.org/0000-0003-2410-0850","observed_orcids":["https://orcid.org/0000-0003-2410-0850"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Silva, S\u00e1mili Wagner da","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5020027021"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8709999918937683},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bv2-cells","display_name":"BV-2 cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lipoprotein-uptake","display_name":"lipoprotein uptake","score":0.6019999980926514},{"id":"https://openalex.org/keywords/lipoprotein-receptors","display_name":"lipoprotein receptors","score":0.4050000011920929},{"id":"https://openalex.org/keywords/lipofuscin-accumulation","display_name":"lipofuscin accumulation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.8740000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7979999780654907},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9430000185966492},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6489999890327454},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.41200000047683716},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.44279998540878296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3109000027179718},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30730000138282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23240000009536743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15549999475479126},{"id":"https://openalex.org/C2778207910","wikidata":"https://www.wikidata.org/wiki/Q397610","display_name":"Agr\u00e9gation","level":3,"score":0.14990000426769257},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.14180000126361847},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.14090000092983246},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.1404000073671341},{"id":"https://openalex.org/C3019940704","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Vascular wall","level":2,"score":0.13410000503063202}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:www.lume.ufrgs.br:10183/276748","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/276748","pdf_url":"https://lume.ufrgs.br/bitstream/10183/276748/1/001206092.pdf","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Disserta\u00e7\u00e3o"}],"best_oa_location":{"id":"pmh:oai:www.lume.ufrgs.br:10183/276748","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/276748","pdf_url":"https://lume.ufrgs.br/bitstream/10183/276748/1/001206092.pdf","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Disserta\u00e7\u00e3o"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6980147995.pdf","grobid_xml":"https://content.openalex.org/works/W6980147995.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2738994915","https://openalex.org/W3046107762","https://openalex.org/W3193853380"],"related_works":["https://openalex.org/W7020679382","https://openalex.org/W7047798516","https://openalex.org/W7023538924","https://openalex.org/W7135238771","https://openalex.org/W2609967055","https://openalex.org/W2164200686","https://openalex.org/W4386592749","https://openalex.org/W4394839998","https://openalex.org/W7064624357","https://openalex.org/W7056076116"],"abstract_inverted_index":{"Hipercolesterolemia":[0],"\u00e9":[1,31],"uma":[2],"disfun\u00e7\u00e3o":[3,306],"metab\u00f3lica":[4],"caracterizada":[5],"por":[6,160,277],"n\u00edveis":[7],"elevados":[8],"de":[9,14,25,35,52,65,72,100,128,139,151,163,178,182,209,220,229,234,249,253,258,283,295,300,305,319,337,339],"colesterol,":[10],"associado":[11,215,290,332],"\u00e0":[12,200,241,256],"Lipoprote\u00edna":[13],"Baixa":[15],"Densidade":[16],"(LDL),":[17],"na":[18,185,189,203,281],"corrente":[19],"sangu\u00ednea.":[20],"Essa":[21],"condi\u00e7\u00e3o":[22],"afeta":[23],"mais":[24],"40%":[26],"da":[27,78,80,88,110,191,227],"popula\u00e7\u00e3o":[28],"mundial":[29],"e":[30,62,95,193,232,297,327],"o":[32,50,113,212,274,286,329],"principal":[33],"fator":[34],"risco":[36,336],"para":[37,172],"doen\u00e7as":[38,53,340],"cardiovasculares.":[39],"Nos":[40],"\u00faltimos":[41],"30":[42],"anos,":[43],"a":[44,58,63,102,136,216,239,244,271,316,333],"hipercolesterolemia":[45],"tem":[46],"sido":[47],"associada":[48],"com":[49],"desenvolvimento":[51,338],"neurodegenerativas,":[54],"sendo":[55,302],"observados":[56],"danos":[57],"barreira":[59],"hematoencef\u00e1lica":[60],"(BHE)":[61],"presen\u00e7a":[64],"elementos":[66,108],"perif\u00e9ricos":[67],"no":[68,218,293,298],"sistema":[69],"nervoso":[70],"central":[71],"indiv\u00edduos":[73],"hipercolesterol\u00eamicos.":[74,344],"Frente":[75],"ao":[76,126,147],"aumento":[77],"permeabilidade":[79],"BHE,":[81],"as":[82,104,121,143,266],"c\u00e9lulas":[83,106,140,197,267,312],"microgliais,":[84],"respons\u00e1veis":[85],"pela":[86],"manuten\u00e7\u00e3o":[87],"homeostase":[89],"cerebral,":[90],"podem":[91,321],"alterar":[92],"sua":[93,98],"atividade":[94],"morfologia,":[96],"adequando":[97],"resposta,":[99],"modo":[101],"proteger":[103],"demais":[105],"dos":[107],"extravasados":[109],"periferia.":[111],"Assim,":[112],"objetivo":[114],"deste":[115],"trabalho":[116],"foi":[117,134,214],"investigar,":[118],"in":[119,308],"vitro,":[120],"altera\u00e7\u00f5es":[122,184,217,292],"induzidas":[123],"em":[124,130,342],"resposta":[125,194],"excesso":[127,275,318],"LDL":[129,192,242,259],"microglias.":[131],"Para":[132],"tanto,":[133],"empregada":[135],"linhagem":[137],"BV-2":[138,198,268],"microgliais":[141,313],"murinas,":[142],"quais":[144],"foram":[145,168],"expostas":[146,199,315],"LDL-colesterol":[148,320],"nas":[149],"concentra\u00e7\u00f5es":[150],"50,":[152],"100":[153],"ou":[154,157,261],"300":[155],"\u03bcg/mL":[156],"PBS":[158],"(controle),":[159],"um":[161,303,317,323,334],"per\u00edodo":[162],"24":[164],"horas.":[165],"Na":[166],"sequ\u00eancia":[167],"realizados":[169],"os":[170],"ensaios":[171],"avaliar":[173],"viabilidade,":[174],"densidade":[175],"celular,":[176,222],"ac\u00famulo":[177,208],"gotas":[179,210,284],"lip\u00eddicas,":[180,211,285],"quantidade":[181],"lisossomos,":[183],"autofagia,":[186,301],"receptores":[187,254],"envolvidos":[188],"endocitose":[190,296],"inflamat\u00f3ria.":[195],"As":[196],"LDL,":[201,250,272],"principalmente":[202],"maior":[204,335],"concentra\u00e7\u00e3o":[205],"testada,":[206],"apresentaram":[207],"que":[213,224,287,311,330],"processo":[219,294,299],"digest\u00e3o":[221],"sem":[223],"houvesse":[225],"modula\u00e7\u00e3o":[226],"produ\u00e7\u00e3o":[228],"citocinas":[230],"pr\u00f3-inflamat\u00f3rias":[231],"gera\u00e7\u00e3o":[233],"esp\u00e9cies":[235],"reativas.":[236],"Al\u00e9m":[237],"disso,":[238],"exposi\u00e7\u00e3o":[240],"modificou":[243],"express\u00e3o":[245],"g\u00eanica":[246],"do":[247],"receptor":[248],"mas":[251],"n\u00e3o":[252],"relacionados":[255],"capta\u00e7\u00e3o":[257],"oxidada":[260],"mediadores":[262],"inflamat\u00f3rios.":[263],"Em":[264],"suma,":[265],"conseguem":[269],"endocitar":[270],"por\u00e9m,":[273],"acaba":[276],"se":[278],"acumular":[279],"internamente":[280],"forma":[282],"pode":[288],"estar":[289],"\u00e0s":[291],"ind\u00edcio":[304],"celular":[307],"vitro.":[309],"Indicando":[310],"quando":[314],"apresentar":[322],"estado":[324],"menos":[325],"responsivo":[326],"funcional,":[328],"estaria":[331],"neurodegenerativas":[341],"pacientes":[343]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}