{"id":"https://openalex.org/W6979976593","doi":null,"title":"ApoE4 pathology in Alzheimer's disease from the perspective of organelle dysfunction in astrocytes","display_name":"ApoE4 pathology in Alzheimer's disease from the perspective of organelle dysfunction in astrocytes","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W6979976593"},"language":"es","primary_location":{"id":"pmh:oai:dnet:tdr_________::43813dcecc21cdc447e6a9f0b8c6a714","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/666659","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/666659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009395559","display_name":"Raquel Larramona\u2010Arcas","orcid":"https://orcid.org/0000-0001-8427-8007","observed_orcids":["https://orcid.org/0000-0001-8427-8007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larramona Arcas, Raquel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5124078801","display_name":"Universitat Aut\u00f2noma de Barcelona. Departament de Bioqu\u00edmica i de Biologia Molecular","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Universitat Aut\u00f2noma de Barcelona. Departament de Bioqu\u00edmica i de Biologia Molecular","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9010000228881836},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/intracellular-calcium-signaling","display_name":"intracellular calcium signaling","score":0.6800000071525574},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.878000020980835},{"id":"https://openalex.org/keywords/lysosomal-calcium-release","display_name":"lysosomal calcium release","score":0.7689999938011169},{"id":"https://openalex.org/keywords/v-atpase","display_name":"V-ATPase","score":0.984000027179718},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium","display_name":"endoplasmic reticulum calcium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.6880000233650208},{"id":"https://openalex.org/keywords/apoe3","display_name":"APOE3","score":0.5759999752044678},{"id":"https://openalex.org/keywords/organelle-dysfunction","display_name":"organelle dysfunction","score":0.7940000295639038},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"calcium imaging","score":0.45100000500679016},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7631999850273132},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.4020000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32910001277923584},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2930999994277954},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2712000012397766},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1979999989271164},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1754000037908554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1696999967098236},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15199999511241913}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dnet:tdr_________::43813dcecc21cdc447e6a9f0b8c6a714","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/666659","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:uabarcelona_::2489025c13074567af00acbe4b78ee73","doi":null,"is_oa":true,"landing_page_url":"http://ddd.uab.cat/record/207868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/666659","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/666659","pdf_url":"http://hdl.handle.net/10803/666659","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:ddd.uab.cat:207868","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/207868","pdf_url":null,"source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"}],"best_oa_location":{"id":"pmh:oai:dnet:tdr_________::43813dcecc21cdc447e6a9f0b8c6a714","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/666659","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W6979976593.pdf","grobid_xml":"https://content.openalex.org/works/W6979976593.grobid-xml"},"referenced_works_count":333,"referenced_works":["https://openalex.org/W656703482","https://openalex.org/W1179766502","https://openalex.org/W1455885126","https://openalex.org/W1513559308","https://openalex.org/W1521246277","https://openalex.org/W1529577194","https://openalex.org/W1551381188","https://openalex.org/W1574604144","https://openalex.org/W1576335263","https://openalex.org/W1577577364","https://openalex.org/W1606053795","https://openalex.org/W1622703765","https://openalex.org/W1718599092","https://openalex.org/W1721570783","https://openalex.org/W1745482744","https://openalex.org/W1778065122","https://openalex.org/W1953584638","https://openalex.org/W1964063168","https://openalex.org/W1964835919","https://openalex.org/W1966707896","https://openalex.org/W1966720891","https://openalex.org/W1966895399","https://openalex.org/W1968352263","https://openalex.org/W1970610359","https://openalex.org/W1971125401","https://openalex.org/W1972077052","https://openalex.org/W1972080672","https://openalex.org/W1972748461","https://openalex.org/W1974152703","https://openalex.org/W1974878596","https://openalex.org/W1975311211","https://openalex.org/W1976444375","https://openalex.org/W1976779549","https://openalex.org/W1981554609","https://openalex.org/W1982468254","https://openalex.org/W1982772537","https://openalex.org/W1983258394","https://openalex.org/W1983832155","https://openalex.org/W1987469323","https://openalex.org/W1988252217","https://openalex.org/W1991481148","https://openalex.org/W1991623690","https://openalex.org/W1992807239","https://openalex.org/W1992935533","https://openalex.org/W1993121582","https://openalex.org/W1993629125","https://openalex.org/W1993696187","https://openalex.org/W1994554610","https://openalex.org/W1997254505","https://openalex.org/W1997279293","https://openalex.org/W1998470073","https://openalex.org/W1999631936","https://openalex.org/W2000809016","https://openalex.org/W2001428953","https://openalex.org/W2001537648","https://openalex.org/W2001618696","https://openalex.org/W2002181764","https://openalex.org/W2002194891","https://openalex.org/W2002744791","https://openalex.org/W2006161539","https://openalex.org/W2007081989","https://openalex.org/W2007263885","https://openalex.org/W2007282102","https://openalex.org/W2009991455","https://openalex.org/W2010484888","https://openalex.org/W2010683624","https://openalex.org/W2010865351","https://openalex.org/W2013111251","https://openalex.org/W2013375919","https://openalex.org/W2013642338","https://openalex.org/W2014897304","https://openalex.org/W2016133602","https://openalex.org/W2016579573","https://openalex.org/W2016814488","https://openalex.org/W2016927879","https://openalex.org/W2017593971","https://openalex.org/W2018019380","https://openalex.org/W2020138925","https://openalex.org/W2021181758","https://openalex.org/W2022908550","https://openalex.org/W2022943683","https://openalex.org/W2023605278","https://openalex.org/W2025060864","https://openalex.org/W2027524490","https://openalex.org/W2027616725","https://openalex.org/W2027997017","https://openalex.org/W2029616852","https://openalex.org/W2030787126","https://openalex.org/W2031675835","https://openalex.org/W2032328804","https://openalex.org/W2032453195","https://openalex.org/W2033155870","https://openalex.org/W2033603289","https://openalex.org/W2036362108","https://openalex.org/W2036688237","https://openalex.org/W2038079237","https://openalex.org/W2039232566","https://openalex.org/W2039848901","https://openalex.org/W2039930606","https://openalex.org/W2041325253","https://openalex.org/W2042681276","https://openalex.org/W2042744781","https://openalex.org/W2044998619","https://openalex.org/W2047460306","https://openalex.org/W2048173148","https://openalex.org/W2050744136","https://openalex.org/W2052870901","https://openalex.org/W2054920080","https://openalex.org/W2056516296","https://openalex.org/W2056648984","https://openalex.org/W2060319077","https://openalex.org/W2060631637","https://openalex.org/W2062562477","https://openalex.org/W2063505049","https://openalex.org/W2063725386","https://openalex.org/W2064119008","https://openalex.org/W2064179601","https://openalex.org/W2065208449","https://openalex.org/W2067678773","https://openalex.org/W2068822326","https://openalex.org/W2069888362","https://openalex.org/W2070658923","https://openalex.org/W2072735872","https://openalex.org/W2074515925","https://openalex.org/W2076199082","https://openalex.org/W2076241970","https://openalex.org/W2076253751","https://openalex.org/W2076310752","https://openalex.org/W2078391920","https://openalex.org/W2079688969","https://openalex.org/W2079823127","https://openalex.org/W2080308068","https://openalex.org/W2080861637","https://openalex.org/W2081388499","https://openalex.org/W2082100107","https://openalex.org/W2084420686","https://openalex.org/W2084634452","https://openalex.org/W2085035881","https://openalex.org/W2087243986","https://openalex.org/W2087667366","https://openalex.org/W2088526201","https://openalex.org/W2089141103","https://openalex.org/W2089781399","https://openalex.org/W2090328262","https://openalex.org/W2090456841","https://openalex.org/W2090971379","https://openalex.org/W2091146826","https://openalex.org/W2092577192","https://openalex.org/W2093716452","https://openalex.org/W2093753108","https://openalex.org/W2094211383","https://openalex.org/W2095931805","https://openalex.org/W2098109360","https://openalex.org/W2098548022","https://openalex.org/W2098722265","https://openalex.org/W2101746758","https://openalex.org/W2103370569","https://openalex.org/W2103825172","https://openalex.org/W2104281661","https://openalex.org/W2105743998","https://openalex.org/W2106902340","https://openalex.org/W2109065242","https://openalex.org/W2109909801","https://openalex.org/W2111723622","https://openalex.org/W2112499304","https://openalex.org/W2113722161","https://openalex.org/W2114337890","https://openalex.org/W2115309238","https://openalex.org/W2115565454","https://openalex.org/W2115709331","https://openalex.org/W2116308842","https://openalex.org/W2117625001","https://openalex.org/W2117769560","https://openalex.org/W2117942944","https://openalex.org/W2121077787","https://openalex.org/W2123597024","https://openalex.org/W2124927590","https://openalex.org/W2125633423","https://openalex.org/W2125872855","https://openalex.org/W2126624770","https://openalex.org/W2128131255","https://openalex.org/W2128783251","https://openalex.org/W2129940176","https://openalex.org/W2130983640","https://openalex.org/W2133411368","https://openalex.org/W2133548029","https://openalex.org/W2134230622","https://openalex.org/W2135120386","https://openalex.org/W2136199683","https://openalex.org/W2137685799","https://openalex.org/W2139636031","https://openalex.org/W2140031122","https://openalex.org/W2140616438","https://openalex.org/W2140718540","https://openalex.org/W2141210743","https://openalex.org/W2142186280","https://openalex.org/W2142194239","https://openalex.org/W2143666437","https://openalex.org/W2143688500","https://openalex.org/W2143802939","https://openalex.org/W2143955562","https://openalex.org/W2147290689","https://openalex.org/W2149304421","https://openalex.org/W2151122745","https://openalex.org/W2151283457","https://openalex.org/W2151731574","https://openalex.org/W2152192643","https://openalex.org/W2153569004","https://openalex.org/W2155957566","https://openalex.org/W2157585985","https://openalex.org/W2159367229","https://openalex.org/W2160490721","https://openalex.org/W2160788420","https://openalex.org/W2161925307","https://openalex.org/W2162128880","https://openalex.org/W2163334026","https://openalex.org/W2164684917","https://openalex.org/W2165021720","https://openalex.org/W2167840686","https://openalex.org/W2168025729","https://openalex.org/W2168130410","https://openalex.org/W2168481427","https://openalex.org/W2168750058","https://openalex.org/W2171346860","https://openalex.org/W2171960085","https://openalex.org/W2172266256","https://openalex.org/W2172786635","https://openalex.org/W2173405668","https://openalex.org/W2180489978","https://openalex.org/W2180760460","https://openalex.org/W2183098386","https://openalex.org/W2185195176","https://openalex.org/W2186763432","https://openalex.org/W2189922927","https://openalex.org/W2190342915","https://openalex.org/W2191292005","https://openalex.org/W2198623424","https://openalex.org/W2223742428","https://openalex.org/W2224041865","https://openalex.org/W2234800739","https://openalex.org/W2234866329","https://openalex.org/W2237126879","https://openalex.org/W2238698772","https://openalex.org/W2257637313","https://openalex.org/W2260140125","https://openalex.org/W2274357590","https://openalex.org/W2277318350","https://openalex.org/W2280788332","https://openalex.org/W2280879984","https://openalex.org/W2283290523","https://openalex.org/W2289895672","https://openalex.org/W2291070922","https://openalex.org/W2296416881","https://openalex.org/W2309151442","https://openalex.org/W2318325474","https://openalex.org/W2322556561","https://openalex.org/W2333105741","https://openalex.org/W2344282546","https://openalex.org/W2344943776","https://openalex.org/W2348040914","https://openalex.org/W2409462039","https://openalex.org/W2439493933","https://openalex.org/W2462114115","https://openalex.org/W2465339739","https://openalex.org/W2470345034","https://openalex.org/W2475929605","https://openalex.org/W2479681541","https://openalex.org/W2495355796","https://openalex.org/W2496718192","https://openalex.org/W2498411827","https://openalex.org/W2514110735","https://openalex.org/W2515175975","https://openalex.org/W2525194959","https://openalex.org/W2526756851","https://openalex.org/W2527503499","https://openalex.org/W2529693680","https://openalex.org/W2541267526","https://openalex.org/W2549569052","https://openalex.org/W2549799731","https://openalex.org/W2550181348","https://openalex.org/W2560393860","https://openalex.org/W2560444134","https://openalex.org/W2560672340","https://openalex.org/W2562785312","https://openalex.org/W2568317134","https://openalex.org/W2579885605","https://openalex.org/W2582695863","https://openalex.org/W2585407814","https://openalex.org/W2587573558","https://openalex.org/W2594971526","https://openalex.org/W2603294829","https://openalex.org/W2606936085","https://openalex.org/W2607261398","https://openalex.org/W2616354017","https://openalex.org/W2624287879","https://openalex.org/W2728178823","https://openalex.org/W2732473219","https://openalex.org/W2737853846","https://openalex.org/W2740094476","https://openalex.org/W2741481567","https://openalex.org/W2742558281","https://openalex.org/W2745657465","https://openalex.org/W2746785627","https://openalex.org/W2748412799","https://openalex.org/W2753769236","https://openalex.org/W2756959977","https://openalex.org/W2757684047","https://openalex.org/W2762340885","https://openalex.org/W2762397244","https://openalex.org/W2765529672","https://openalex.org/W2769484728","https://openalex.org/W2775642640","https://openalex.org/W2776096008","https://openalex.org/W2777525962","https://openalex.org/W2781911216","https://openalex.org/W2782344173","https://openalex.org/W2782519641","https://openalex.org/W2784281836","https://openalex.org/W2786430800","https://openalex.org/W2787153892","https://openalex.org/W2790863694","https://openalex.org/W2794308625","https://openalex.org/W2794553092","https://openalex.org/W2796923525","https://openalex.org/W2798230823","https://openalex.org/W2805798400","https://openalex.org/W2807958953","https://openalex.org/W2807959547","https://openalex.org/W2810838937","https://openalex.org/W4234290491","https://openalex.org/W4238230369","https://openalex.org/W4249726489","https://openalex.org/W7101026039"],"related_works":["https://openalex.org/W3034140617","https://openalex.org/W2766642292","https://openalex.org/W7015209506","https://openalex.org/W7150794613","https://openalex.org/W1999262130","https://openalex.org/W2406267873","https://openalex.org/W2745815338","https://openalex.org/W7005351174","https://openalex.org/W7000139940","https://openalex.org/W7212256896"],"abstract_inverted_index":{"La":[0,39,71,247],"enfermedad":[1,27,60,112,462,507,556],"de":[2,9,20,49,54,58,69,113,117,145,151,153,162,165,172,179,194,204,218,222,225,234,249,265,274,277,291,316,319,348,354,361,364,373,393,444,448,460,463,470,474,488,497,508,521,533,546,557,560,566],"Alzheimer":[3,509],"es":[4,228,252],"la":[5,14,55,59,97,111,115,131,141,149,163,195,216,223,263,272,289,295,314,362,365,378,388,398,419,423,437,446,461,468,475,506,540,555],"forma":[6,56,132],"mas":[7],"com\u00fan":[8],"demencia":[10],"en":[11,83,104,110,185,208,239,254,267,283,300,307,311,334,387,397,406,431,434,456,467,501],"edades":[12],"avanzadas,":[13],"cual":[15],"afecta":[16,30],"a":[17,33,37,137,341,441,554,561,564],"40":[18],"millones":[19],"personas":[21],"alrededor":[22],"del":[23,236,297,403,425,482,568],"mundo.":[24],"Es":[25],"una":[26,201,231,391,401],"compleja":[28],"que":[29,95,129,156,168,262,288,370,418,436,479,511,551],"no":[31,321,357],"solo":[32],"neuronas,":[34],"sino":[35],"tambi\u00e9n":[36,260],"astrocitos.":[38,432],"Apolipoprote\u00edna":[40],"E4":[41],"(ApoE4)":[42],"ha":[43],"sido":[44],"descrita":[45],"como":[46,124,513],"el":[47,88,268,345],"factor":[48],"riesgo":[50],"gen\u00e9tico":[51],"m\u00e1s":[52],"importante":[53],"espor\u00e1dica":[57],"y":[61,119,148,197,344,400,427,477,510,536],"adem\u00e1s,":[62],"los":[63,66,74,157,188,209,240,245,284,374,381,409,449,547],"astrocitos":[64,127,158,189,210,241,285,375,382,410],"son":[65],"principales":[67,106],"secretores":[68],"esta.":[70],"investigaci\u00f3n":[72],"sobre":[73],"mecanismos":[75],"patog\u00e9nicos":[76],"causados":[77],"por":[78,182,198,230,280,325,339,415],"esta":[79,519],"apolipoprote\u00edna":[80],"est\u00e1":[81],"centrada":[82],"su":[84,562],"rol":[85],"extracelular.":[86],"Por":[87,329],"contrario,":[89],"nosotros":[90,492],"analizamos":[91],"las":[92,120,275,308,312,317,326,335,352,371,428,457,480,486,489,522,544],"desregulaciones":[93],"intracelulares":[94],"causa":[96],"ApoE4.":[98,142],"En":[99,350,412,538],"nuestro":[100],"estudio,":[101],"nos":[102],"centramos":[103],"2":[105],"procesos":[107],"fisiol\u00f3gicos":[108],"alterados":[109],"Alzheimer:":[114],"se\u00f1alizaci\u00f3n":[116,424],"calcio":[118,146,173,180,205,219,235,250,278,292,298,320,426],"funciones":[121,429,545],"mitocondriales.":[122],"Utilizamos":[123],"modelo":[125],"celular,":[126],"inmortalizados":[128],"expresan":[130],"humana":[133],"ApoE3":[134,376],"(no":[135],"asociada":[136],"ninguna":[138],"patolog\u00eda)":[139],"o":[140],"Utilizando":[143],"indicadores":[144],"fluorescentes":[147],"t\u00e9cnica":[150],"Imagen":[152],"Calcio,":[154],"determinamos":[155],"ApoE4":[159,211,242,356,383,420,438,541],"tienen":[160,384],"alteraciones":[161,333,452],"homeostasis":[164],"calcio,":[166],"ya":[167,287,478],"presentan":[169],"menores":[170],"niveles":[171],"intracelular":[174],"basal":[175],"pero":[176],"mayores":[177],"se\u00f1ales":[178],"inducidas":[181,279],"est\u00edmulos":[183],"purin\u00e9rgicos":[184,227,282],"comparaci\u00f3n":[186,407],"con":[187,244,408,505],"ApoE3.":[190,246,411],"Una":[191],"mayor":[192,202,232],"actividad":[193],"V-ATPasa":[196],"lo":[199,442],"tanto,":[200],"entrada":[203,248,290],"al":[206],"lisosoma":[207],"explica":[212],"estas":[213,301,451,471],"alteraciones.":[214],"Adem\u00e1s,":[215],"salida":[217],"lisosomal":[220,299],"despu\u00e9s":[221,360],"activaci\u00f3n":[224],"receptores":[226,281],"seguida":[229],"movilizaci\u00f3n":[233],"ret\u00edculo":[237],"endopl\u00e1smico":[238],"comparados":[243],"extracelular":[251,270,293],"similar":[253],"ambos":[255],"tipos":[256],"celulares.":[257],"Nuestros":[258],"estudios":[259],"demuestran":[261],"falta":[264],"lipoprote\u00ednas":[266,327],"medio":[269],"aumenta":[271],"magnitud":[273,315],"respuestas":[276,318],"ApoE3,":[286],"amplifica":[294],"liberaci\u00f3n":[296],"c\u00e9lulas.":[302],"Esta":[303,517],"caracter\u00edstica":[304],"se":[305,322,439],"pierde":[306],"c\u00e9lulas":[309,355,490],"ApoE4,":[310],"cuales":[313],"ve":[323],"afectada":[324],"extracelulares.":[328],"otro":[330],"lado,":[331],"describimos":[332],"din\u00e1micas":[336],"mitocondriales":[337,430],"determinadas":[338],"microscopia":[340],"tiempo":[342],"real":[343],"marcaje":[346],"fluorescente":[347],"mitocondrias.":[349],"particular,":[351],"mitocondrias":[353,372],"realizan":[358],"fisi\u00f3n":[359],"inhibici\u00f3n":[363],"fosforilaci\u00f3n":[366],"oxidativa":[367],"mitocondrial,":[368,390],"mientras":[369],"si":[377],"realizan.":[379],"Asimismo,":[380],"un":[385,495,549],"incremento":[386],"movilidad":[389],"reducci\u00f3n":[392,402],"Parkina,":[394],"prote\u00edna":[395,531],"involucrada":[396],"mitofagia":[399],"ADN":[404],"mitocondrial":[405],"resumen,":[413],"demostramos":[414],"primera":[416],"vez":[417],"end\u00f3gena":[421,542],"altera":[422,543],"Teniendo":[433],"cuenta":[435],"expresa":[440],"largo":[443],"toda":[445],"vida":[447],"individuos,":[450],"astroc\u00edticas":[453,499],"podr\u00edan":[454],"aparecer":[455],"primeras":[458,472],"etapas":[459,473],"Alzheimer.":[464],"Para":[465],"avanzar":[466],"detecci\u00f3n":[469,563],"patolog\u00eda,":[476],"prote\u00ednas":[481,498,523],"l\u00edquido":[483,503,569],"cefalorraqu\u00eddeo":[484],"reflejan":[485],"funcionalidad":[487],"cerebrales,":[491],"hemos":[493],"identificado":[494],"grupo":[496],"presentes":[500],"este":[502],"relacionadas":[504],"proponemos":[512],"firma":[514,518],"funcional":[515],"astroc\u00edtica.":[516],"compuesta":[520],"S100B,":[524],"ApoE,":[525],"prostaglandina":[526],"D2":[527],"sintetasa,":[528],"cistatina":[529],"3,":[530],"integral":[532],"membrana":[534],"2C":[535],"clusterina.":[537],"general,":[539],"astrocitos,":[548],"fen\u00f3meno":[550],"puede":[552],"contribuir":[553],"Alzheimer,":[558],"adem\u00e1s":[559],"trav\u00e9s":[565],"biomarcadores":[567],"cefalorraqu\u00eddeo.":[570]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-10T00:00:00"}
