{"id":"https://openalex.org/W6979782892","doi":null,"title":"ADVANTAGES OF THE SUPRAMOLECULAR ORGANISATION OF THE RESPIRATORY CHAIN: KINETIC IMPROVEMENT AND LIMITED PRODUCTION OF REACTIVE OXYGEN SPECIES.","display_name":"ADVANTAGES OF THE SUPRAMOLECULAR ORGANISATION OF THE RESPIRATORY CHAIN: KINETIC IMPROVEMENT AND LIMITED PRODUCTION OF REACTIVE OXYGEN SPECIES.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W6979782892"},"language":"en","primary_location":{"id":"pmh:oai:cris.unibo.it:11585/405757","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/405757","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031518448","display_name":"Maria Luisa Genova","orcid":"https://orcid.org/0000-0002-9176-3630","observed_orcids":["https://orcid.org/0000-0002-9176-3630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"GENOVA, MARIA LUISA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030834563","display_name":"Evelina Maranzana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MARANZANA, EVELINA SUSANA BEATRIZ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045919146","display_name":"Giorgio Lenaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LENAZ, GIORGIO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Anna Ida Falasca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Ida Falasca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4956744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13012","display_name":"Coenzyme Q10 studies and effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complex-i","display_name":"complex I","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cytochrome-bc1-complex","display_name":"cytochrome bc1 complex","score":0.9950000047683716},{"id":"https://openalex.org/keywords/electron-transfer-kinetics","display_name":"electron transfer kinetics","score":0.7210000157356262},{"id":"https://openalex.org/keywords/substrate-channeling","display_name":"substrate channeling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.7400000095367432},{"id":"https://openalex.org/keywords/nadh-oxidase","display_name":"NADH oxidase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/metabolic-control-analysis","display_name":"metabolic control analysis","score":0.781000018119812},{"id":"https://openalex.org/keywords/supercomplex-assembly","display_name":"supercomplex assembly","score":0.5529999732971191},{"id":"https://openalex.org/keywords/lipid-content","display_name":"lipid content","score":0.7409999966621399},{"id":"https://openalex.org/keywords/proteoliposomes","display_name":"proteoliposomes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.859000027179718},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.8379999995231628},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8450000286102295},{"id":"https://openalex.org/keywords/dodecyl-maltoside","display_name":"dodecyl maltoside","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5547000169754028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4318999946117401},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33660000562667847},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.311599999666214},{"id":"https://openalex.org/C3020761558","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Mitochondrial respiratory chain","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.23720000684261322},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2296999990940094},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.22130000591278076}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:cris.unibo.it:11585/405757","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/405757","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015650234","https://openalex.org/W1998696969","https://openalex.org/W2769784377","https://openalex.org/W2022372519","https://openalex.org/W2479761428","https://openalex.org/W2006709909","https://openalex.org/W2170913127","https://openalex.org/W2006849545","https://openalex.org/W1963530746","https://openalex.org/W7048255630"],"abstract_inverted_index":{"A":[0],"large":[1],"proportion":[2],"of":[3,12,65,75,96,99,113,126,130,149,158,167,187,203,222,261,271,287,309],"the":[4,44,48,66,70,94,104,111,114,140,144,150,156,159,164,183,193,201,209,220,233,265,272,285,307],"mitochondrial":[5,134,300,338],"respiratory":[6,115,210,339],"chain":[7,340],"complexes":[8],"in":[9,16,47,90,103,143,227,231,293,297,312,316,344],"a":[10,32,39,131,322,345],"variety":[11],"organisms":[13],"is":[14,29,180,303,341],"arranged":[15],"supramolecular":[17],"assemblies":[18],"called":[19],"supercomplexes.":[20],"Supercomplex":[21],"assembly":[22,112,186],"between":[23,274],"Complex":[24,27,100,188,225,244,251,275,278,290],"I":[25,226,276,291],"and":[26,62,146,185,277,296,315,325],"III":[28,279],"not":[30],"just":[31],"mere":[33],"structural":[34],"feature":[35],"since":[36],"it":[37],"confers":[38],"kinetic":[40,73,348],"advantage":[41],"by":[42,79,128,218,224,280],"facilitating":[43],"electron":[45],"transfer":[46],"Coenzyme":[49],"Q":[50],"region":[51],"(substrate":[52],"channelling)":[53],"more":[54],"efficiently":[55],"then":[56],"any":[57],"process":[58],"based":[59],"on":[60,139],"diffusion":[61],"random":[63],"collision":[64],"acting":[67],"partners.":[68],"On":[69],"other":[71],"hand,":[72],"evaluation":[74],"NADH":[76],"oxidase":[77],"activity":[78],"Metabolic":[80],"Control":[81],"Analysis":[82],"indicates":[83],"that":[84,124,147,177,195,267],"cytochrome":[85],"c":[86],"obeys":[87],"pool":[88],"behaviour":[89],"mammalian":[91],"mitochondria,":[92],"despite":[93],"presence":[95],"some":[97],"molecules":[98],"IV":[101],"comprised":[102],"supercomplex":[105,160,178,196,234,346],"[1].":[106],"The":[107,259,337],"forces":[108],"responsible":[109],"for":[110,182],"supercomplexes":[116,127],"are":[117],"still":[118],"little":[119],"understood.":[120],"We":[121,212],"have":[122,213],"shown":[123],"formation":[125,157,202],"reconstitution":[129,154],"binary":[132],"I/III":[133,245,252],"protein":[135,170,257],"fraction":[136],"strongly":[137,283],"depends":[138],"lipid":[141,168],"content":[142],"proteoliposomes":[145,295],"peroxidation":[148],"lipids":[151],"prior":[152],"to":[153,169,256,305],"prevents":[155],"I1III2":[161,235],"even":[162],"under":[163],"optimal":[165],"condition":[166],"ratio.":[171,258],"In":[172],"addition,":[173],"several":[174],"studies":[175],"demonstrated":[176],"association":[179,197,273],"required":[181],"stability":[184],"I.":[189],"Indirect":[190],"considerations":[191],"support":[192,264],"view":[194,266],"may":[198],"also":[199],"limit":[200],"reactive":[204],"oxygen":[205],"species":[206],"(ROS)":[207],"from":[208,289],"chain.":[211],"directly":[214],"addressed":[215],"this":[216],"issue":[217],"testing":[219],"production":[221],"ROS":[223],"two":[228],"experimental":[229],"systems":[230],"which":[232],"was":[236],"dissociated:":[237],"(i)":[238],"bovine":[239,298],"heart":[240,299],"mitochondria":[241],"or":[242,269],"liposome-reconstituted":[243,250],"treated":[246],"with":[247],"dodecyl-maltoside;":[248],"(ii)":[249],"at":[253],"high":[254],"phospholipids":[255],"results":[260],"our":[262],"investigation":[263],"disruption":[268],"prevention":[270],"different":[281],"means":[282],"enhances":[284],"generation":[286],"superoxide":[288],"both":[292],"reconstituted":[294],"membranes.":[301],"It":[302],"easy":[304],"foresee":[306],"implications":[308],"these":[310],"findings":[311],"human":[313],"diseases":[314],"aging,":[317],"where":[318],"oxidative":[319],"stress":[320],"plays":[321],"major":[323],"etiologic":[324],"pathogenic":[326],"role.\\n\\n[1]":[327],"C.":[328],"Bianchi,":[329],"M.L.":[330],"Genova,":[331],"G.":[332,335],"Parenti":[333],"Castelli,":[334],"Lenaz,":[336],"partially":[342],"organized":[343],"assembly:":[347],"evidence":[349],"using":[350],"flux":[351],"control":[352],"analysis,":[353],"J.":[354],"Biol.":[355],"Chem.":[356],"279":[357],"(2004)":[358],"36562-9.":[359]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}