{"id":"https://openalex.org/W6979060924","doi":null,"title":"[Primary hyperaldosteronism].","display_name":"[Primary hyperaldosteronism].","publication_year":1995,"publication_date":"1995-03-01","ids":{"openalex":"https://openalex.org/W6979060924","pmid":"https://pubmed.ncbi.nlm.nih.gov/7651282"},"language":"it","primary_location":{"id":"pmid:7651282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7651282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"G Opocher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Opocher","raw_affiliation_strings":["Istituto di Semeiotica Medica, Universit\u00e0 degli Studi, Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Semeiotica Medica, Universit\u00e0 degli Studi, Padova","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066700658","display_name":"Stefano Rocco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rocco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533814","display_name":"G. Carpen\u00e9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Carpen\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055546265","display_name":"Decio Armanini","orcid":"https://orcid.org/0000-0002-6433-5155","observed_orcids":["https://orcid.org/0000-0002-6433-5155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Armanini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"F Mantero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Mantero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"20","issue":"1","first_page":"49","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aldosterone-producing-adenoma","display_name":"aldosterone-producing adenoma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/idiopathic-hyperaldosteronism","display_name":"idiopathic hyperaldosteronism","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.628000020980835},{"id":"https://openalex.org/keywords/hypokalemia","display_name":"hypokalemia","score":1.0},{"id":"https://openalex.org/keywords/renin-activity","display_name":"renin activity","score":0.5950000286102295},{"id":"https://openalex.org/keywords/plasma-aldosterone-concentration","display_name":"plasma aldosterone","score":0.7889999747276306},{"id":"https://openalex.org/keywords/urinary-aldosterone","display_name":"urinary aldosterone","score":0.8029999732971191},{"id":"https://openalex.org/keywords/captopril-test","display_name":"captopril test","score":0.6330000162124634},{"id":"https://openalex.org/keywords/angiotensin-ii-infusion","display_name":"angiotensin II infusion","score":0.8259999752044678},{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9729999899864197},{"id":"https://openalex.org/keywords/adrenal-vein-sampling","display_name":"adrenal vein sampling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/adrenal-scintigraphy","display_name":"adrenal scintigraphy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/familial-hyperaldosteronism","display_name":"familial hyperaldosteronism","score":0.7400000095367432},{"id":"https://openalex.org/keywords/11beta-hydroxylase-deficiency","display_name":"11beta-hydroxylase deficiency","score":0.8289999961853027},{"id":"https://openalex.org/keywords/18-hydroxycorticosterone","display_name":"18-hydroxycorticosterone","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.8335000276565552},{"id":"https://openalex.org/C2776292634","wikidata":"https://www.wikidata.org/wiki/Q1640860","display_name":"Hyperaldosteronism","level":3,"score":0.8313999772071838},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.8066999912261963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7562999725341797},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.6783000230789185},{"id":"https://openalex.org/C2778242168","wikidata":"https://www.wikidata.org/wiki/Q794086","display_name":"Hypokalemia","level":2,"score":0.6669999957084656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6003000140190125},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5774000287055969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5001000165939331},{"id":"https://openalex.org/C2778914232","wikidata":"https://www.wikidata.org/wiki/Q4684749","display_name":"Adrenal adenoma","level":3,"score":0.4325000047683716},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.397599995136261},{"id":"https://openalex.org/C2779479957","wikidata":"https://www.wikidata.org/wiki/Q421119","display_name":"Captopril","level":3,"score":0.3831999897956848},{"id":"https://openalex.org/C125567185","wikidata":"https://www.wikidata.org/wiki/Q3267428","display_name":"Supine position","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C2777097880","wikidata":"https://www.wikidata.org/wiki/Q988405","display_name":"Essential hypertension","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.30809998512268066},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.2554999887943268},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C2781243531","wikidata":"https://www.wikidata.org/wiki/Q3296793","display_name":"Renovascular hypertension","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000302","descriptor_name":"Adrenal Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012083","descriptor_name":"Renin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013252","descriptor_name":"Steroid 11-beta-Hydroxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019405","descriptor_name":"Cytochrome P-450 CYP11B2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7651282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7651282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva endocrinologica","raw_type":"Journal Article"},{"id":"pmh:oai:www.research.unipd.it:11577/2497457","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/2497457","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1980871247","https://openalex.org/W83224170","https://openalex.org/W4387317808","https://openalex.org/W2414680853","https://openalex.org/W2331623886","https://openalex.org/W1810015956","https://openalex.org/W2373744320","https://openalex.org/W196745539","https://openalex.org/W2054618061","https://openalex.org/W2024256442"],"abstract_inverted_index":{"The":[0,53],"diagnosis":[1],"of":[2,11,14,36,45,50,61,132,159,170,176,185,189,218,223,232,243],"primary":[3,65],"aldosteronism":[4,66],"(PA)":[5],"is":[6],"based":[7],"on":[8],"the":[9,12,56,81,171,212,216,240,244],"finding":[10],"combination":[13],"elevated":[15],"urinary":[16],"and/or":[17],"plasma":[18,105,111,148],"aldosterone":[19,106,112,118,149,172],"and":[20,28,38,55,76,86,103,123,134,155,175,197,236],"suppressed":[21],"renin":[22],"activity":[23],"in":[24,33,69,100,115,129,136,150,156],"patients":[25,63,152,160],"with":[26,64,153,161,164,228],"hypertension":[27],"hypokalemia.":[29],"However,":[30],"PA":[31],"consists":[32],"a":[34,42,157,183,186],"number":[35],"subsets,":[37],"diagnostic":[39],"criteria":[40],"for":[41],"correct":[43],"identification":[44],"surgically":[46],"remediable":[47],"forms":[48],"are":[49,67],"great":[51],"interest.":[52],"methods":[54],"results":[57,203],"concerning":[58],"our":[59],"series":[60],"113":[62],"presented":[68],"this":[70],"review.":[71],"Aldosterone":[72],"producing":[73],"adenoma":[74,141,165],"(APA)":[75],"idiopathic":[77],"hyperaldosteronism":[78,225],"(IHA)":[79],"were":[80,107,142,226],"most":[82,97,130,151],"frequent":[83],"forms,":[84],"51%":[85],"44%":[87],"respectively.":[88],"They":[89],"had":[90,166],"similar":[91,202],"BP":[92],"levels,":[93],"but":[94,109,138],"hypokalemia":[95],"was":[96,113,127],"frequently":[98],"found":[99],"APA.":[101],"Urinary":[102],"upright":[104,121],"similar,":[108],"supine":[110],"lower":[114],"IHA.":[116,162],"Plasma":[117],"response":[119],"to":[120,146,239],"posture":[122],"angiotensin":[124],"II":[125],"infusion":[126],"absent":[128],"cases":[131,222],"APA":[133],"present":[135],"IHA,":[137],"occasionally":[139],"renin-responsive":[140],"found.":[143],"Captopril":[144],"failed":[145],"decrease":[147],"APA,":[154],"subgroup":[158],"Patients":[163],"also":[167],"higher":[168],"values":[169],"precursor":[173],"18-OH-B,":[174,234],"atrial":[177],"natriuretic":[178],"peptide":[179],"(ANP),":[180],"probably":[181],"as":[182],"consequence":[184],"greater":[187],"degree":[188],"volume":[190],"expansion.":[191],"Among":[192,215],"morphological":[193],"studies,":[194],"CT":[195],"scan":[196],"adrenal":[198,206],"radio-cholesterol":[199],"scintiscan":[200],"provided":[201],"(85%":[204],"accuracy):":[205],"vein":[207],"catheterization":[208],"clarified":[209],"almost":[210],"all":[211],"remaining":[213],"cases.":[214],"subsets":[217],"PA,":[219],"3":[220],"familiar":[221],"dex-suppressible":[224],"recognized,":[227],"characteristically":[229],"high":[230],"levels":[231],"aldo,":[233],"18-OH-cortisol":[235],"18-oxo-cortisol,":[237],"due":[238],"genetic":[241],"abnormalities":[242],"11-18":[245],"hydroxylase":[246],"system.(ABSTRACT":[247],"TRUNCATED":[248],"AT":[249],"250":[250],"WORDS)":[251]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}