{"id":"https://openalex.org/W69784355","doi":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","title":"A new type of transforming growth factor\u2010beta, TGF\u2010beta 3.","display_name":"A new type of transforming growth factor\u2010beta, TGF\u2010beta 3.","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W69784355","doi":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","mag":"69784355","pmid":"https://pubmed.ncbi.nlm.nih.gov/3208746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/454948"},"language":"en","primary_location":{"id":"doi:10.1002/j.1460-2075.1988.tb03257.x","doi":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/454948","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068725149","display_name":"Rik Derynck","orcid":"https://orcid.org/0000-0003-4407-6990","observed_orcids":["https://orcid.org/0000-0003-4407-6990"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Derynck","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090498460","display_name":"Patricia B. Lindquist","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. B. Lindquist","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071027972","display_name":"Angela L. Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Lee","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045526815","display_name":"D Wen","orcid":"https://orcid.org/0009-0008-8727-4253","observed_orcids":["https://orcid.org/0009-0008-8727-4253"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Wen","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024878629","display_name":"Joseph A. Tamm","orcid":"https://orcid.org/0000-0002-7977-2809","observed_orcids":["https://orcid.org/0000-0002-7977-2809"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Tamm","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039806331","display_name":"Jeannette L. Graycar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. L. Graycar","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069594554","display_name":"Lucy M. Rhee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Rhee","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113614352","display_name":"Anthony J. Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. J. Mason","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106082313","display_name":"D.A. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. A. Miller","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. J. Coffey","raw_affiliation_strings":["Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":12.9326,"has_fulltext":false,"cited_by_count":389,"citation_normalized_percentile":{"value":0.99366072,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"3737","last_page":"3743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgfbeta3","display_name":"TGF-beta3","score":0.921999990940094},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7710000276565552},{"id":"https://openalex.org/keywords/amino-acid-sequence","display_name":"amino acid sequence","score":0.9279999732971191},{"id":"https://openalex.org/keywords/protein-precursors","display_name":"precursor protein","score":0.6819999814033508},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.7570000290870667},{"id":"https://openalex.org/keywords/exon-organization","display_name":"exon organization","score":0.6819999814033508},{"id":"https://openalex.org/keywords/sequence-conservation","display_name":"sequence conservation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.5490000247955322},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.9890000224113464},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.4919416606426239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4680126905441284},{"id":"https://openalex.org/C2777496998","wikidata":"https://www.wikidata.org/wiki/Q1536587","display_name":"Miller","level":2,"score":0.44439053535461426},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12042465806007385},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.10833513736724854}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D015291","descriptor_name":"Transforming Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1460-2075.1988.tb03257.x","doi":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1460-2075.1988.tb03257.x","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:454948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/454948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:3208746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3208746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:454948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/454948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5101280814","display_name":"TRANSFORMING GROWTH FACTORS IN NEOPLASTIC TRANSFORMATION","funder_award_id":"R35CA042572","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1423657362","https://openalex.org/W1495519011","https://openalex.org/W1524114372","https://openalex.org/W1587325941","https://openalex.org/W1595226323","https://openalex.org/W1600868878","https://openalex.org/W1608791497","https://openalex.org/W1627068912","https://openalex.org/W1660743658","https://openalex.org/W1966507279","https://openalex.org/W1970525240","https://openalex.org/W1973644988","https://openalex.org/W1979877257","https://openalex.org/W1987568997","https://openalex.org/W1990112474","https://openalex.org/W2007768242","https://openalex.org/W2009105413","https://openalex.org/W2012481680","https://openalex.org/W2017449280","https://openalex.org/W2017692699","https://openalex.org/W2027726633","https://openalex.org/W2037457710","https://openalex.org/W2041029576","https://openalex.org/W2044648543","https://openalex.org/W2050620572","https://openalex.org/W2050687675","https://openalex.org/W2051590029","https://openalex.org/W2054684040","https://openalex.org/W2064185923","https://openalex.org/W2077077811","https://openalex.org/W2082831376","https://openalex.org/W2087863947","https://openalex.org/W2100048123","https://openalex.org/W2105300288","https://openalex.org/W2108085784","https://openalex.org/W2108104357","https://openalex.org/W2119209023","https://openalex.org/W2136064255","https://openalex.org/W2138879032","https://openalex.org/W2161454032","https://openalex.org/W2165022623","https://openalex.org/W2336518283"],"related_works":["https://openalex.org/W2089221634","https://openalex.org/W1989897445","https://openalex.org/W2030774731","https://openalex.org/W1608791497","https://openalex.org/W7035279214","https://openalex.org/W1833351599","https://openalex.org/W2172193595","https://openalex.org/W2331249819","https://openalex.org/W1976692127","https://openalex.org/W2007898091"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
