{"id":"https://openalex.org/W69719375","doi":null,"title":"Effects of whole-body irradiation on neonatally thymectomized mice. Incidence of benign and malignant tumors.","display_name":"Effects of whole-body irradiation on neonatally thymectomized mice. Incidence of benign and malignant tumors.","publication_year":1978,"publication_date":"1978-05-01","ids":{"openalex":"https://openalex.org/W69719375","mag":"69719375","pmid":"https://pubmed.ncbi.nlm.nih.gov/645825","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018198"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2018198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018198","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113461904","display_name":"R E Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006001660","display_name":"J. L. Howarth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Howarth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111719460","display_name":"G. M. Troup","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G M Troup","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00632695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"91","issue":"2","first_page":"217","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.48410001397132874,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.48410001397132874,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.20669999718666077,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.19820000231266022,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-thymectomy","display_name":"neonatal thymectomy","score":0.9330000281333923},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/radiation-induced-cancer","display_name":"radiation-induced cancer","score":0.6600000262260437},{"id":"https://openalex.org/keywords/benign-tumors","display_name":"benign tumors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multiple-primary-neoplasms","display_name":"multiple primary neoplasms","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thymus-dependent-immune-response","display_name":"thymus-dependent immune response","score":0.8169999718666077},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5180000066757202},{"id":"https://openalex.org/keywords/germ-free-mice","display_name":"germ-free mice","score":0.8330000042915344},{"id":"https://openalex.org/keywords/tumor-incidence","display_name":"tumor incidence","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2779615886","wikidata":"https://www.wikidata.org/wiki/Q3090790","display_name":"Thymectomy","level":3,"score":0.923527181148529},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6724890470504761},{"id":"https://openalex.org/C3019541388","wikidata":"https://www.wikidata.org/wiki/Q1986672","display_name":"Whole body irradiation","level":3,"score":0.608723521232605},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.602645218372345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5826274156570435},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.49178746342658997},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4755815267562866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4485147297382355},{"id":"https://openalex.org/C2780635560","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplasm","level":2,"score":0.4316455125808716},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36871397495269775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34387385845184326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34245216846466064},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26281875371932983},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.21120402216911316},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.12404325604438782},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009378","descriptor_name":"Neoplasms, Multiple Primary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D013934","descriptor_name":"Thymectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:2018198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:645825","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/645825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Comparative Study"},{"id":"mag:69719375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/645825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2018198","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2018198","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W85582129","https://openalex.org/W113782491","https://openalex.org/W211697509","https://openalex.org/W1482193898","https://openalex.org/W1483194800","https://openalex.org/W1483582997","https://openalex.org/W1496414205","https://openalex.org/W1509577793","https://openalex.org/W1524207749","https://openalex.org/W1538961217","https://openalex.org/W1545977344","https://openalex.org/W1556957752","https://openalex.org/W1991709537","https://openalex.org/W2011736353","https://openalex.org/W2012434010","https://openalex.org/W2018584938","https://openalex.org/W2039652680","https://openalex.org/W2041370911","https://openalex.org/W2050838768","https://openalex.org/W2058409289","https://openalex.org/W2066615768","https://openalex.org/W2111042594","https://openalex.org/W2124726696","https://openalex.org/W2141495155","https://openalex.org/W2147787458","https://openalex.org/W2162567855","https://openalex.org/W2274873113","https://openalex.org/W2460046313","https://openalex.org/W2764599102","https://openalex.org/W2766751225","https://openalex.org/W4313308953"],"related_works":["https://openalex.org/W146811278","https://openalex.org/W1483582997","https://openalex.org/W1894080600","https://openalex.org/W1911036081","https://openalex.org/W7144925464","https://openalex.org/W1547183719","https://openalex.org/W2134006307","https://openalex.org/W2322518382","https://openalex.org/W1572693566","https://openalex.org/W1995481438"],"abstract_inverted_index":{"The":[0],"individual":[1,75,123],"and":[2,8,16,62,65],"combined":[3],"effects":[4,38,110,140],"of":[5,14,23,35,39,46,50,60,69,85,91,97,111,121,126,137,141,148,152],"neonatal":[6],"thymectomy":[7,55,112],"whole-body":[9,142],"irradiation":[10,40,114,143],"on":[11],"the":[12,24,36,47,51,58,67,94,108,119,122,138,149,153],"prevalence":[13,68],"benign":[15,61],"malignant":[17,63],"tumors":[18,64],"in":[19,73,104],"germ-free":[20],"female":[21],"mice":[22],"Charles":[25],"Rivers":[26],"line":[27],"were":[28],"studied":[29],"to":[30,44,79],"determine":[31],"if":[32],"a":[33,135],"portion":[34,136],"tumorigenic":[37],"can":[41],"be":[42],"attributed":[43],"injury":[45],"thymic-dependent":[48,150],"component":[49,151],"immune":[52,154],"response.":[53,155],"Neonatal":[54],"increased":[56,88],"a)":[57],"incidence":[59,90],"b)":[66],"multiple":[70],"primary":[71],"neoplasms":[72],"an":[74],"mouse.":[76],"Whole-body":[77],"exposure":[78],"700":[80],"rad":[81],"at":[82],"6":[83],"weeks":[84],"age":[86],"further":[87],"th":[89],"tumors,":[92],"but":[93],"relative":[95],"magnitude":[96],"this":[98,131],"increase":[99],"was":[100],"less":[101,116],"pronounced":[102,117],"than":[103,118],"sham-operated":[105],"controls.":[106],"Thus,":[107],"cumulative":[109],"plus":[113],"are":[115],"sum":[120],"effects.":[124],"One":[125],"several":[127],"possible":[128],"explanations":[129],"for":[130],"observation":[132],"is":[133,144],"that":[134],"carcinogenic":[139],"mediated":[145],"by":[146],"suppression":[147]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
