{"id":"https://openalex.org/W69653808","doi":null,"title":"Elucidation of Snm1B Function","display_name":"Elucidation of Snm1B Function","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W69653808","mag":"69653808"},"language":"ar","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/5775","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/5775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043805953","display_name":"Jay Robert Stringer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jay Robert Stringer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043805953"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gins-complex","display_name":"GINS complex","score":0.9850000143051147},{"id":"https://openalex.org/keywords/interstrand-crosslink-repair","display_name":"interstrand crosslink repair","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mus81","display_name":"MUS81","score":0.6650000214576721},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.7699999809265137},{"id":"https://openalex.org/keywords/telomere-protection","display_name":"telomere protection","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.5649999976158142},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7250000238418579},{"id":"https://openalex.org/keywords/chromatin-localization","display_name":"chromatin localization","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.515999972820282},{"id":"https://openalex.org/keywords/yeast-two-hybrid-screen","display_name":"yeast two-hybrid screen","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4519883096218109},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13987770676612854},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.08803761005401611}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/5775","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/5775","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:69653808","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/5775","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W89564149","https://openalex.org/W181292466","https://openalex.org/W1497143641","https://openalex.org/W1578840375","https://openalex.org/W1578945800","https://openalex.org/W1964622938","https://openalex.org/W1965695542","https://openalex.org/W1968516742","https://openalex.org/W1970801073","https://openalex.org/W1972313386","https://openalex.org/W1972655555","https://openalex.org/W1974993967","https://openalex.org/W1975001355","https://openalex.org/W1978411020","https://openalex.org/W1982199027","https://openalex.org/W1983673827","https://openalex.org/W1985710832","https://openalex.org/W1985910710","https://openalex.org/W1985964699","https://openalex.org/W1987079136","https://openalex.org/W1989465302","https://openalex.org/W1996831741","https://openalex.org/W1999334180","https://openalex.org/W2001273027","https://openalex.org/W2001828972","https://openalex.org/W2004007316","https://openalex.org/W2005083925","https://openalex.org/W2005567329","https://openalex.org/W2010806621","https://openalex.org/W2011522975","https://openalex.org/W2015615504","https://openalex.org/W2018458310","https://openalex.org/W2024131694","https://openalex.org/W2031000298","https://openalex.org/W2032407757","https://openalex.org/W2035389897","https://openalex.org/W2038661569","https://openalex.org/W2042796276","https://openalex.org/W2044430178","https://openalex.org/W2049883174","https://openalex.org/W2051176267","https://openalex.org/W2051990601","https://openalex.org/W2055727475","https://openalex.org/W2057958054","https://openalex.org/W2058800908","https://openalex.org/W2061907379","https://openalex.org/W2070879510","https://openalex.org/W2072744580","https://openalex.org/W2073315455","https://openalex.org/W2074615071","https://openalex.org/W2074730941","https://openalex.org/W2078932864","https://openalex.org/W2080222318","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2089689396","https://openalex.org/W2096349500","https://openalex.org/W2096607093","https://openalex.org/W2098585738","https://openalex.org/W2099367992","https://openalex.org/W2102839588","https://openalex.org/W2103441012","https://openalex.org/W2105148815","https://openalex.org/W2105413529","https://openalex.org/W2107720277","https://openalex.org/W2108482850","https://openalex.org/W2108572433","https://openalex.org/W2110817748","https://openalex.org/W2111003464","https://openalex.org/W2111501761","https://openalex.org/W2114342948","https://openalex.org/W2115383745","https://openalex.org/W2120365943","https://openalex.org/W2128426508","https://openalex.org/W2128717251","https://openalex.org/W2130730147","https://openalex.org/W2131391919","https://openalex.org/W2138643693","https://openalex.org/W2140303823","https://openalex.org/W2142544392","https://openalex.org/W2145080831","https://openalex.org/W2146666713","https://openalex.org/W2146677747","https://openalex.org/W2147770635","https://openalex.org/W2151656619","https://openalex.org/W2153025234","https://openalex.org/W2153314251","https://openalex.org/W2158279161","https://openalex.org/W2159168998","https://openalex.org/W2160773412","https://openalex.org/W2160812540","https://openalex.org/W2162385336","https://openalex.org/W2162681116","https://openalex.org/W2170609809","https://openalex.org/W2319007677","https://openalex.org/W4406600162","https://openalex.org/W7095856360"],"related_works":["https://openalex.org/W2134148681","https://openalex.org/W2078932864","https://openalex.org/W2015615504","https://openalex.org/W2151062921","https://openalex.org/W89564149","https://openalex.org/W150672228","https://openalex.org/W2105148815","https://openalex.org/W2010806621","https://openalex.org/W2169378176","https://openalex.org/W1602550411"],"abstract_inverted_index":{"The":[0,83],"protein":[1,8,77,145],"Snm1B":[2,22,46,113,140,179,191],"binds":[3,123],"to":[4,10,56,60,80,101,124,141,154,177],"the":[5,37,61,75,95,108,131,137,144,168,173],"telomere":[6],"binding":[7,59,170],"TRF2":[9],"help":[11],"protect":[12],"telomeres":[13],"from":[14,25,116],"DNA":[15,24,41],"damage":[16],"during":[17],"S":[18],"phase.":[19],"In":[20],"addition,":[21],"protects":[23],"agents":[26],"that":[27,34,121,151],"induce":[28],"interstrand":[29],"crosslinks":[30],"(ICLs),":[31],"lethal":[32],"lesions":[33],"covalently":[35],"attach":[36],"opposite":[38],"strands":[39],"of":[40,63,74,97,110,127,130,133,139,167,175,190],"together.":[42],"To":[43],"elucidate":[44],"how":[45],"performs":[47],"these":[48,134],"functions":[49],"I":[50,68,105],"performed":[51],"a":[52,72,147,185],"yeast":[53],"two-hybrid":[54],"screen":[55,67],"identify":[57],"proteins":[58],"C-terminus":[62],"Snm1B.":[64,82,128],"From":[65],"this":[66],"identified":[69],"PSF2":[70,98,111,122,176,193],"(GINS2),":[71],"member":[73],"tetrameric":[76],"complex":[78,85],"GINS,":[79],"bind":[81],"GINS":[84],"is":[86,152],"required":[87,153],"for":[88,187],"replication":[89],"initiation":[90],"and":[91,112,119],"elongation.":[92],"Of":[93],"interest,":[94],"knockdown":[96],"sensitizes":[99],"cells":[100,118],"ICL":[102,164,195],"inducing":[103],"agents.":[104],"therefore":[106],"tested":[107],"interaction":[109,189],"by":[114],"co-immunoprecipitation":[115],"human":[117],"discovered":[120],"two":[125],"regions":[126,135],"Deletion":[129,166],"first":[132],"inhibited":[136],"ability":[138,174],"co-immunoprecipitate":[142],"with":[143,192],"Mus81,":[146],"structure":[148],"specific":[149],"endonuclease":[150],"form":[155],"double":[156],"strand":[157],"breaks":[158],"(DSBs)":[159],"as":[160],"an":[161,188],"intermediate":[162],"in":[163,194],"repair.":[165,196],"second":[169],"region":[171],"reduced":[172],"localize":[178],"onto":[180],"chromatin.":[181],"These":[182],"data":[183],"support":[184],"role":[186]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
