{"id":"https://openalex.org/W6964883288","doi":"https://doi.org/10.25673/117872","title":"Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy : a multicenter study on 2419 patients from the prospective skin cancer registry ADOReg","display_name":"Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy : a multicenter study on 2419 patients from the prospective skin cancer registry ADOReg","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W6964883288","doi":"https://doi.org/10.25673/117872"},"language":"en","primary_location":{"id":"doi:10.25673/117872","doi":"https://doi.org/10.25673/117872","is_oa":true,"landing_page_url":"https://doi.org/10.25673/117872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401651","display_name":"Digitalen Hochschulbibliothek Sachsen-Anhalt (Universit\u00e4ts- und Landesbibliothek Sachsen-Anhalt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122374","host_organization_name":"Universit\u00e4ts Frauenklinik","host_organization_lineage":["https://openalex.org/I4210122374"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25673/117872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028956153","display_name":"Julian K\u00f6tt","orcid":"https://orcid.org/0000-0003-2073-3909","observed_orcids":["https://orcid.org/0000-0003-2073-3909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K\u00f6tt, Julian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Sunderk\u00f6tter, Cord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunderk\u00f6tter, Cord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"[Und Viele Weitere]","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"[Und Viele Weitere]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41171397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oma","display_name":"OMA","score":0.7850000262260437},{"id":"https://openalex.org/keywords/advanced-melanoma","display_name":"advanced melanoma","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/antithrombotic-therapy","display_name":"antithrombotic therapy","score":0.9210000038146973},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.7739999890327454},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.9909999966621399},{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.9959999918937683},{"id":"https://openalex.org/keywords/phenprocoumon","display_name":"phenprocoumon","score":0.9860000014305115},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.75},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/best-overall-response","display_name":"best overall response","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9453999996185303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7003999948501587},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6065999865531921},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5960999727249146},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5425000190734863},{"id":"https://openalex.org/C2777015399","wikidata":"https://www.wikidata.org/wiki/Q4775337","display_name":"Antithrombotic","level":2,"score":0.5425000190734863},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5403000116348267},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.4043000042438507},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.39160001277923584},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.3785000145435333},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.36059999465942383},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.35929998755455017},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33739998936653137},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.3370000123977661},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3212999999523163},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25673/117872","doi":"https://doi.org/10.25673/117872","is_oa":true,"landing_page_url":"https://doi.org/10.25673/117872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401651","display_name":"Digitalen Hochschulbibliothek Sachsen-Anhalt (Universit\u00e4ts- und Landesbibliothek Sachsen-Anhalt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122374","host_organization_name":"Universit\u00e4ts Frauenklinik","host_organization_lineage":["https://openalex.org/I4210122374"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.25673/117872","doi":"https://doi.org/10.25673/117872","is_oa":true,"landing_page_url":"https://doi.org/10.25673/117872","pdf_url":null,"source":{"id":"https://openalex.org/S4306401651","display_name":"Digitalen Hochschulbibliothek Sachsen-Anhalt (Universit\u00e4ts- und Landesbibliothek Sachsen-Anhalt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210122374","host_organization_name":"Universit\u00e4ts Frauenklinik","host_organization_lineage":["https://openalex.org/I4210122374"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.818290114402771,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Cancer":[1],"immunotherapy":[2],"has":[3,64],"revolutionized":[4],"melanoma":[5,75,273],"treatment,":[6],"but":[7],"the":[8,16,32,49,81,133,283],"high":[9],"number":[10],"of":[11,20,34,72,135,225,266,286],"non-":[12],"responders":[13],"still":[14],"emphasizes":[15],"need":[17],"for":[18,25,216],"improvement":[19],"therapy.":[21],"One":[22],"potential":[23],"avenue":[24],"enhancing":[26],"anti-":[27],"tumor":[28,50,52],"treatment":[29],"is":[30],"through":[31],"modulation":[33],"coagulation":[35],"and":[36,54,160,268],"platelet":[37,111,290],"activity.":[38],"Both":[39],"have":[40],"been":[41,65],"found":[42],"to":[43,174,187,196,209,214,242,254,281,292],"play":[44],"an":[45],"important":[46],"role":[47],"in":[48,95,171,194,231,272],"microenvironment,":[51],"growth":[53],"metastasis.":[55],"Preclinical":[56],"studies":[57,278],"indicate":[58],"a":[59,70,262],"beneficial":[60],"effect,":[61],"clinical":[62],"data":[63],"inconsistent.":[66],"Methods:":[67],"We":[68],"examined":[69],"cohort":[71],"advanced,":[73],"non-resectable":[74],"patients":[76,99,172,195,215,232,274],"(n":[77,115,124,141],"=2419)":[78],"derived":[79],"from":[80],"German":[82],"prospective":[83],"multicenter":[84],"skin":[85],"cancer":[86],"registry":[87],"ADOReg,":[88],"who":[89,233],"were":[90,100,152],"treated":[91],"with":[92],"immune":[93],"checkpoint":[94],"hibitors":[96],"(ICI).":[97],"The":[98,149],"classified":[101],"based":[102],"on":[103],"whether":[104],"it":[105],"was":[106,169,221],"documented":[107,173],"that":[108],"they":[109],"received":[110,234],"aggregation":[112],"inhibition":[113,291],"(PAI)":[114],"=137)":[116],"(acetylsalicylic":[117],"acid":[118],"(ASA)":[119],"or":[120,137,246,289],"clopidogrel),":[121],"anticoagulation":[122,128,288],"(AC)":[123],"=185)":[125],"(direct":[126],"oral":[127],"(DOAC),":[129],"phenprocoumon,":[130],"heparins)":[131],"at":[132,143],"start":[134],"ICI":[136,147,293],"no":[138,218],"antithrombotic":[139,219],"cation":[140],"=2097)":[142],"any":[144],"point":[145],"during":[146],"treatment.":[148,294],"study":[150,260],"endpoints":[151],"best":[153],"overall":[154,161],"response":[155],"(BOR),":[156],"progression-free":[157],"survival":[158,162],"(PFS)":[159],"(OS).":[163],"Results:":[164],"A":[165],"significantly":[166],"improved":[167],"PFS":[168],"observed":[170],"receive":[175,197],"ASA":[176],"(15.1":[177,199],"vs":[178],"6.4":[179,201],"months,":[180,202],"HR":[181,203],"0.67,":[182],"95":[183,205,238,250],"%":[184,206,239,251],"CI:":[185,207,240,252],"0.5":[186],"0.88,":[188],"p":[189,211,244,256],"=0.0047)":[190],"as":[191,193],"well":[192],"AC":[198],"vs.":[200],"0.7,":[204],"0.53":[208],"0.91,":[210],"=0.01)":[212],"compared":[213],"whom":[217],"medication":[220,271],"documented.":[222],"Multivariate":[223],"analysis":[224],"OS":[226],"showed":[227],"significant":[228],"risk":[229],"reduction":[230],"DOAC":[235],"(HR":[236],"0.68,":[237],"0.49":[241],"0.92,":[243],"=0.0170)":[245],"phenprocoumon":[247],"(HR:":[248],"0.44,":[249],"0.19":[253],"0.85,":[255],"=0.0301).":[257],"Conclusion:":[258],"Our":[259],"indicates":[261],"positive":[263],"prognostic":[264],"effect":[265],"anticoagulant":[267],"antiplatelet":[269],"concomitant":[270],"receiving":[275],"ICI.":[276],"Further":[277],"are":[279],"needed":[280],"confrim":[282],"cancer-related":[284],"benefit":[285],"adding":[287]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}