{"id":"https://openalex.org/W69646243","doi":null,"title":"Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients.","display_name":"Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients.","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W69646243","mag":"69646243","pmid":"https://pubmed.ncbi.nlm.nih.gov/8574734"},"language":"en","primary_location":{"id":"pmid:8574734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8574734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032069568","display_name":"Michel A.L. Deltenre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102955","display_name":"Centre Hospitalier Universitaire Brugmann","ror":"https://ror.org/011apjk30","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210102955"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Deltenre","raw_affiliation_strings":["Gastroenterology Unit, University Hospital Brugmann, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, University Hospital Brugmann, Brussels, Belgium","institution_ids":["https://openalex.org/I4210102955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112134555","display_name":"C. Jonas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Jonas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112837132","display_name":"M. Van Gossum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M van Gossum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010729630","display_name":"Michel Buset","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Buset","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J Otero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Otero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057303244","display_name":"Erik De Koster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E De Koster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4304,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.61787614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7 Suppl 1","issue":null,"first_page":"S39","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9660000205039978},{"id":"https://openalex.org/keywords/omeprazole","display_name":"omeprazole","score":0.9769999980926514},{"id":"https://openalex.org/keywords/clarithromycin","display_name":"clarithromycin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/amoxicillin","display_name":"amoxicillin","score":0.875},{"id":"https://openalex.org/keywords/colloidal-bismuth-subcitrate","display_name":"bismuth subcitrate","score":0.949999988079071},{"id":"https://openalex.org/keywords/tinidazole","display_name":"tinidazole","score":1.0},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/functional-dyspepsia","display_name":"functional dyspepsia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.5400000214576721},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9415268898010254},{"id":"https://openalex.org/C2777498785","wikidata":"https://www.wikidata.org/wiki/Q422210","display_name":"Omeprazole","level":2,"score":0.8950316309928894},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.8825265169143677},{"id":"https://openalex.org/C2780626017","wikidata":"https://www.wikidata.org/wiki/Q1321320","display_name":"Tinidazole","level":4,"score":0.8416334390640259},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7743895053863525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7476074695587158},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7193460464477539},{"id":"https://openalex.org/C2780708398","wikidata":"https://www.wikidata.org/wiki/Q4101224","display_name":"Rapid urease test","level":4,"score":0.6320362091064453},{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.606316328048706},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4619143009185791},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.41888633370399475},{"id":"https://openalex.org/C2775981797","wikidata":"https://www.wikidata.org/wiki/Q638366","display_name":"Breath test","level":3,"score":0.41490140557289124},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.39669179916381836},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.32087159156799316},{"id":"https://openalex.org/C2908868296","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori infection","level":3,"score":0.225749671459198},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.09536731243133545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004415","descriptor_name":"Dyspepsia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016145","descriptor_name":"Endoscopy, Digestive System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8574734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8574734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of gastroenterology & hepatology","raw_type":"Clinical Trial"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/127546","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/127546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European journal of gastroenterology & hepatology, 7 (SUPPL. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:69646243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8574734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083010168","https://openalex.org/W113896798","https://openalex.org/W1996614767","https://openalex.org/W8228641","https://openalex.org/W2083572957","https://openalex.org/W1940117125","https://openalex.org/W2053346032","https://openalex.org/W1988903293","https://openalex.org/W2398053662","https://openalex.org/W1972503094"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"compare":[2],"the":[3,18,64,67,78,81,85,93,109,121,195],"efficacies":[4],"of":[5,20,48,66,80,124,133,147,156,178,197,201,213],"omeprazole-based":[6],"antimicrobial":[7],"therapies":[8],"in":[9,33,113],"Helicobacter":[10],"pylori-positive":[11,209,218],"patients.":[12],"PATIENTS":[13],"AND":[14],"METHODS:":[15],"We":[16],"report":[17],"results":[19,102],"seven":[21],"therapeutic":[22],"trials":[23],"combining":[24],"omeprazole,":[25],"clarithromycin,":[26],"amoxycillin,":[27],"colloidal":[28],"bismuth":[29],"subcitrate":[30],"and":[31,69,136,164,190,210,219],"tinidazole":[32],"198":[34],"patients":[35,125,150,161,180],"(peptic":[36],"ulcer":[37,90],"disease/non-ulcerative":[38],"dyspepsia,":[39],"137/61)":[40],"to":[41,173],"eradicate":[42],"H.":[43,188,208,217],"pylori":[44],"infection.":[45],"The":[46],"diagnosis":[47],"infection":[49],"was":[50,57,71,118],"performed":[51],"by":[52,84],"Sydney":[53,86],"system":[54,87],"biopsies,":[55],"compliance":[56],"checked":[58],"after":[59,77,194],"a":[60,106,139],"pill":[61],"count":[62],"at":[63,73],"end":[65,79,196],"treatment":[68,82,140],"eradication":[70,114],"assessed":[72],"least":[74],"4":[75],"weeks":[76,193],"either":[83,154],"for":[88,97],"peptic":[89],"disease":[91],"or":[92,168],"urease":[94],"breath":[95],"test":[96],"non-ulcerative":[98],"dyspepsia.":[99],"RESULTS:":[100],"When":[101],"were":[103,171,186,204,216],"analysed":[104],"on":[105],"protocol":[107],"basis,":[108],"only":[110],"significant":[111],"difference":[112],"(P":[115],"=":[116],"0.006)":[117],"found":[119],"between":[120],"total":[122],"population":[123],"treated":[126],"with":[127,181],"amoxycillin-based":[128],"combinations":[129],"(27":[130,175],"eradications":[131,145],"out":[132,146,153,200,212],"48":[134],"patients)":[135],"those":[137],"given":[138],"that":[141],"included":[142],"clarithromycin":[143,163],"(84":[144],"108).":[148],"Forty-two":[149],"(21%)":[151],"dropped":[152],"because":[155,169],"side":[157],"effects":[158],"(10":[159],"among":[160],"taking":[162,166],"two":[165],"amoxycillin)":[167],"they":[170],"lost":[172],"follow-up":[174],"patients).":[176],"Out":[177],"64":[179,202,214],"active":[182,221],"ulcers,":[183],"43":[184],"(67%)":[185],"both":[187],"pylori-negative":[189],"ulcer-free":[191,205],"4-8":[192],"therapy,":[198],"12":[199],"(19%)":[203],"but":[206],"remained":[207],"nine":[211],"(14%)":[215],"had":[220],"ulceration.":[222]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}