{"id":"https://openalex.org/W69543750","doi":"https://doi.org/10.1023/a:1027381412574","title":"Nucleotide Transport Through the Cystic Fibrosis Transmembrane Conductance Regulator","display_name":"Nucleotide Transport Through the Cystic Fibrosis Transmembrane Conductance Regulator","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W69543750","doi":"https://doi.org/10.1023/a:1027381412574","mag":"69543750","pmid":"https://pubmed.ncbi.nlm.nih.gov/9217964"},"language":"en","primary_location":{"id":"doi:10.1023/a:1027381412574","doi":"https://doi.org/10.1023/a:1027381412574","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1027381412574","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065381860","display_name":"Horacio F. Cantiello","orcid":"https://orcid.org/0000-0001-7973-0804","observed_orcids":["https://orcid.org/0000-0001-7973-0804"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Horacio F. Cantiello","raw_affiliation_strings":["Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, Massachusetts 02129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Massachusetts General Hospital East, 149 13th Street, Charlestown, Massachusetts 02129","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065381860"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":1960,"currency":"USD","value_usd":1960},"apc_paid":null,"fwci":2.2042,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.8633318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"17","issue":"2","first_page":"147","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis-transmembrane-conductance-regulator","display_name":"cystic fibrosis transmembrane conductance regulator","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nucleotide-transport","display_name":"nucleotide transport","score":0.8349999785423279},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8399999737739563},{"id":"https://openalex.org/keywords/intracellular-atp","display_name":"intracellular ATP","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.9514039754867554},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7366780042648315},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6958360075950623},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.664076030254364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5804374814033508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5734344124794006},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5496854782104492},{"id":"https://openalex.org/C113027372","wikidata":"https://www.wikidata.org/wiki/Q24768350","display_name":"Cyclic nucleotide-binding domain","level":4,"score":0.5451660752296448},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4886923134326935},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.45524898171424866},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.42956188321113586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2925374507904053},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2846500277519226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13812017440795898},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07053971290588379}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019005","descriptor_name":"Cystic Fibrosis Transmembrane Conductance Regulator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1027381412574","doi":"https://doi.org/10.1023/a:1027381412574","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1027381412574","pdf_url":null,"source":{"id":"https://openalex.org/S124713461","display_name":"Bioscience Reports","issn_l":"0144-8463","issn":["0144-8463","1573-4935"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience Reports","raw_type":"journal-article"},{"id":"pmid:9217964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9217964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioscience reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333587","display_name":"Sanofi Genzyme","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W24492042","https://openalex.org/W232415930","https://openalex.org/W386028995","https://openalex.org/W653308076","https://openalex.org/W1231338517","https://openalex.org/W1501455003","https://openalex.org/W1520633122","https://openalex.org/W1533844265","https://openalex.org/W1544973014","https://openalex.org/W1558503775","https://openalex.org/W1608154971","https://openalex.org/W1635112096","https://openalex.org/W1650939144","https://openalex.org/W1818106540","https://openalex.org/W1883764934","https://openalex.org/W1963552073","https://openalex.org/W1963761882","https://openalex.org/W1973868711","https://openalex.org/W1975264523","https://openalex.org/W1978149400","https://openalex.org/W1982071077","https://openalex.org/W1996845076","https://openalex.org/W2002816571","https://openalex.org/W2019099644","https://openalex.org/W2020691476","https://openalex.org/W2023245703","https://openalex.org/W2023610376","https://openalex.org/W2027079587","https://openalex.org/W2028533496","https://openalex.org/W2029510455","https://openalex.org/W2035177679","https://openalex.org/W2036648910","https://openalex.org/W2036774130","https://openalex.org/W2039599894","https://openalex.org/W2042305464","https://openalex.org/W2042727263","https://openalex.org/W2044594872","https://openalex.org/W2047930213","https://openalex.org/W2049683781","https://openalex.org/W2055241554","https://openalex.org/W2065040546","https://openalex.org/W2066318082","https://openalex.org/W2068233575","https://openalex.org/W2071416115","https://openalex.org/W2073543009","https://openalex.org/W2082064626","https://openalex.org/W2091259347","https://openalex.org/W2097572779","https://openalex.org/W2097878215","https://openalex.org/W2103416189","https://openalex.org/W2112006233","https://openalex.org/W2118234018","https://openalex.org/W2126458759","https://openalex.org/W2151213366","https://openalex.org/W2159398732","https://openalex.org/W2161239684","https://openalex.org/W2170734806","https://openalex.org/W2172134989","https://openalex.org/W2229146067","https://openalex.org/W2261623825","https://openalex.org/W2338243080","https://openalex.org/W3149555810"],"related_works":["https://openalex.org/W2078603719","https://openalex.org/W2145080287","https://openalex.org/W2094312105","https://openalex.org/W2181968890","https://openalex.org/W7097388923","https://openalex.org/W2112006233","https://openalex.org/W2340233470","https://openalex.org/W1533844265","https://openalex.org/W2417741365","https://openalex.org/W2045202796"],"abstract_inverted_index":{"The":[0,91],"cystic":[1,120],"fibrosis":[2],"transmembrane":[3],"conductance":[4],"regulator":[5],"(CFTR)":[6],"is":[7,53,93],"a":[8,108,113],"member":[9],"of":[10,13,29,49,56,64,69,80,100,119],"the":[11,27,47,54,62,77,97,104,117],"superfamily":[12],"ATP-binding":[14],"cassette":[15],"(ABC)":[16],"transporters,":[17],"also":[18,44],"known":[19],"as":[20,74,76],"traffic":[21],"ATPases,":[22],"which":[23],"are":[24,43,86],"implicated":[25,45],"in":[26,46,83,88,116],"movement":[28,48,63],"various":[30],"substrates.":[31],"Recent":[32],"studies":[33],"indicate":[34],"that":[35],"CFTR":[36,70],"and":[37,71],"other":[38],"closely":[39],"related":[40,72],"ABC":[41],"transporters":[42],"cellular":[50,65,101],"ATP.":[51],"This":[52],"subject":[55],"current":[57],"controversy.":[58],"Therefore,":[59],"evidence":[60],"for":[61,96],"nucleotides":[66],"by":[67,107],"expression":[68],"molecules,":[73],"well":[75],"potential":[78],"significance":[79],"ATP-permeable":[81],"channels":[82],"cell":[84],"physiology,":[85],"reviewed":[87],"this":[89],"study.":[90],"hypothesis":[92],"thus":[94],"forwarded":[95],"improper":[98],"delivery":[99],"ATP":[102],"to":[103,111],"extracellular":[105],"milieu":[106],"dysfunctional":[109],"CFTR,":[110],"be":[112],"relevant":[114],"factor":[115],"onset":[118],"fibrosis.":[121]},"counts_by_year":[{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
