{"id":"https://openalex.org/W69522639","doi":null,"title":"Virus-like particles elicit enhanced immunity to influenza and provide the scaffolding for a novel vaccine platform","display_name":"Virus-like particles elicit enhanced immunity to influenza and provide the scaffolding for a novel vaccine platform","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W69522639","mag":"69522639"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.montana.edu:1/3001","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/3001","pdf_url":"https://scholarworks.montana.edu/bitstreams/45d387f1-0e92-405e-8fb8-96783f9525a6/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.montana.edu/bitstreams/45d387f1-0e92-405e-8fb8-96783f9525a6/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019198664","display_name":"Laura E. Richert","orcid":"https://orcid.org/0000-0002-7682-2225","observed_orcids":["https://orcid.org/0000-0002-7682-2225"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Laura Richert","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7682-2225","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5019198664"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virus-like-particles","display_name":"virus-like particles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.7960000038146973},{"id":"https://openalex.org/keywords/small-heat-shock-proteins","display_name":"small heat shock proteins","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ovalbumin-conjugation","display_name":"ovalbumin conjugation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bronchus-associated-lymphoid-tissue","display_name":"bronchus-associated lymphoid tissue","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tracheobronchial-lymph-nodes","display_name":"tracheobronchial lymph nodes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dendritic-cell-trafficking","display_name":"dendritic cell trafficking","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9279999732971191},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.7099999785423279},{"id":"https://openalex.org/keywords/polymeric-ig-receptor","display_name":"polymeric Ig receptor","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mucosal-iga","display_name":"mucosal IgA","score":0.8769999742507935},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/t-follicular-helper-cells","display_name":"T follicular helper cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.4749999940395355}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6054182052612305},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.584040641784668},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5153531432151794},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.49371060729026794},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.41612476110458374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4107869863510132},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3449188768863678},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2820173501968384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28198355436325073},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.montana.edu:1/3001","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/3001","pdf_url":"https://scholarworks.montana.edu/bitstreams/45d387f1-0e92-405e-8fb8-96783f9525a6/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:69522639","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.montana.edu/xmlui/bitstream/1/3001/1/RichertL1212.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.montana.edu:1/3001","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/3001","pdf_url":"https://scholarworks.montana.edu/bitstreams/45d387f1-0e92-405e-8fb8-96783f9525a6/download","source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G515965682","display_name":null,"funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320306203","funder_display_name":"M.J. Murdock Charitable Trust"},{"id":"https://openalex.org/G528260468","display_name":"Rocky Mountain Regional Center of Excellence or Biodefense and Emerging Infectiou","funder_award_id":"U54AI065357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5941605982","display_name":"A nanoparticle-based immunoprophylactic strategy that protects against a broad sp","funder_award_id":"R56AI089458","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6663034490","display_name":null,"funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320311310","funder_display_name":"Montana State University"},{"id":"https://openalex.org/G7136290703","display_name":"Pre-existing iBALT structures facilitate accelerated humoral immune responses in","funder_award_id":"R21AI083520","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8171351810","display_name":"Center for Zoonotic and Emerging Infectious Diseases","funder_award_id":"P20GM103500","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000867577","display_name":"MT INBRE: A Multidisciplinary Research Network","funder_award_id":"P20GM103474","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306203","display_name":"M.J. Murdock Charitable Trust","ror":"https://ror.org/02hxgd925"},{"id":"https://openalex.org/F4320311310","display_name":"Montana State University","ror":"https://ror.org/02w0trx84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W69522639.pdf","grobid_xml":"https://content.openalex.org/works/W69522639.grobid-xml"},"referenced_works_count":371,"referenced_works":["https://openalex.org/W12004686","https://openalex.org/W19635477","https://openalex.org/W29983323","https://openalex.org/W37119766","https://openalex.org/W1495349209","https://openalex.org/W1496828046","https://openalex.org/W1510276262","https://openalex.org/W1515043996","https://openalex.org/W1518785179","https://openalex.org/W1529149321","https://openalex.org/W1537886660","https://openalex.org/W1538324889","https://openalex.org/W1562057469","https://openalex.org/W1579102917","https://openalex.org/W1584203472","https://openalex.org/W1585610099","https://openalex.org/W1595632800","https://openalex.org/W1608215415","https://openalex.org/W1663429151","https://openalex.org/W1691546288","https://openalex.org/W1693495046","https://openalex.org/W1722080576","https://openalex.org/W1786547448","https://openalex.org/W1790977108","https://openalex.org/W1826726928","https://openalex.org/W1828996061","https://openalex.org/W1833207062","https://openalex.org/W1834820177","https://openalex.org/W1841966953","https://openalex.org/W1852410481","https://openalex.org/W1872237323","https://openalex.org/W1886229228","https://openalex.org/W1930325143","https://openalex.org/W1950729478","https://openalex.org/W1963667977","https://openalex.org/W1963675143","https://openalex.org/W1964539025","https://openalex.org/W1965448804","https://openalex.org/W1965727970","https://openalex.org/W1967362690","https://openalex.org/W1967994686","https://openalex.org/W1968459329","https://openalex.org/W1968515860","https://openalex.org/W1969169898","https://openalex.org/W1969295709","https://openalex.org/W1969501683","https://openalex.org/W1969715124","https://openalex.org/W1969792215","https://openalex.org/W1971662199","https://openalex.org/W1972570430","https://openalex.org/W1972643490","https://openalex.org/W1973122974","https://openalex.org/W1974720935","https://openalex.org/W1975296966","https://openalex.org/W1976753839","https://openalex.org/W1977142289","https://openalex.org/W1978741561","https://openalex.org/W1980177337","https://openalex.org/W1980673401","https://openalex.org/W1981008354","https://openalex.org/W1981531030","https://openalex.org/W1982229304","https://openalex.org/W1983495673","https://openalex.org/W1983793263","https://openalex.org/W1984833230","https://openalex.org/W1986216579","https://openalex.org/W1987360610","https://openalex.org/W1987519563","https://openalex.org/W1988338839","https://openalex.org/W1989961345","https://openalex.org/W1990083653","https://openalex.org/W1990258307","https://openalex.org/W1991309663","https://openalex.org/W1991701295","https://openalex.org/W1991807175","https://openalex.org/W1992024672","https://openalex.org/W1992730641","https://openalex.org/W1992974015","https://openalex.org/W1993547722","https://openalex.org/W1993728991","https://openalex.org/W1994310347","https://openalex.org/W1994391392","https://openalex.org/W1994700075","https://openalex.org/W1995172530","https://openalex.org/W1995510727","https://openalex.org/W1995744610","https://openalex.org/W2001193614","https://openalex.org/W2001285947","https://openalex.org/W2001788095","https://openalex.org/W2002632348","https://openalex.org/W2003608711","https://openalex.org/W2003687800","https://openalex.org/W2004197760","https://openalex.org/W2004312418","https://openalex.org/W2004313038","https://openalex.org/W2005164282","https://openalex.org/W2008955150","https://openalex.org/W2009127910","https://openalex.org/W2009415926","https://openalex.org/W2009682425","https://openalex.org/W2010472544","https://openalex.org/W2011270644","https://openalex.org/W2011325395","https://openalex.org/W2013574284","https://openalex.org/W2014449927","https://openalex.org/W2015411077","https://openalex.org/W2015919529","https://openalex.org/W2015957523","https://openalex.org/W2017076506","https://openalex.org/W2018293931","https://openalex.org/W2018347072","https://openalex.org/W2020339139","https://openalex.org/W2020435673","https://openalex.org/W2022291864","https://openalex.org/W2022547167","https://openalex.org/W2023355270","https://openalex.org/W2023383225","https://openalex.org/W2023812091","https://openalex.org/W2024524568","https://openalex.org/W2026571103","https://openalex.org/W2026667514","https://openalex.org/W2026973139","https://openalex.org/W2026995229","https://openalex.org/W2027824063","https://openalex.org/W2028476437","https://openalex.org/W2028575270","https://openalex.org/W2030346528","https://openalex.org/W2030846337","https://openalex.org/W2030895743","https://openalex.org/W2031302274","https://openalex.org/W2031997312","https://openalex.org/W2032026183","https://openalex.org/W2032841462","https://openalex.org/W2033511257","https://openalex.org/W2034312059","https://openalex.org/W2036589586","https://openalex.org/W2037024044","https://openalex.org/W2037380046","https://openalex.org/W2038151327","https://openalex.org/W2038545770","https://openalex.org/W2038786161","https://openalex.org/W2038859753","https://openalex.org/W2039009483","https://openalex.org/W2039200386","https://openalex.org/W2042063390","https://openalex.org/W2042626190","https://openalex.org/W2043326389","https://openalex.org/W2044210137","https://openalex.org/W2045121415","https://openalex.org/W2045465609","https://openalex.org/W2045893773","https://openalex.org/W2045934762","https://openalex.org/W2046637170","https://openalex.org/W2047505752","https://openalex.org/W2048299290","https://openalex.org/W2048706422","https://openalex.org/W2050084139","https://openalex.org/W2050603521","https://openalex.org/W2050875329","https://openalex.org/W2051381790","https://openalex.org/W2051752235","https://openalex.org/W2052260269","https://openalex.org/W2052267565","https://openalex.org/W2052878201","https://openalex.org/W2053208357","https://openalex.org/W2055082310","https://openalex.org/W2055283107","https://openalex.org/W2055861239","https://openalex.org/W2056400193","https://openalex.org/W2058539497","https://openalex.org/W2058740609","https://openalex.org/W2059046642","https://openalex.org/W2059984497","https://openalex.org/W2060377782","https://openalex.org/W2063240654","https://openalex.org/W2065734531","https://openalex.org/W2066506357","https://openalex.org/W2066728093","https://openalex.org/W2066950276","https://openalex.org/W2067780578","https://openalex.org/W2068592034","https://openalex.org/W2069122035","https://openalex.org/W2070308191","https://openalex.org/W2070823443","https://openalex.org/W2071147619","https://openalex.org/W2071347193","https://openalex.org/W2072045111","https://openalex.org/W2073234751","https://openalex.org/W2075150851","https://openalex.org/W2076916349","https://openalex.org/W2077332396","https://openalex.org/W2078710631","https://openalex.org/W2078731100","https://openalex.org/W2079507740","https://openalex.org/W2080422015","https://openalex.org/W2080728601","https://openalex.org/W2080798548","https://openalex.org/W2081671448","https://openalex.org/W2081749766","https://openalex.org/W2082030984","https://openalex.org/W2082473379","https://openalex.org/W2082601653","https://openalex.org/W2082647108","https://openalex.org/W2082871926","https://openalex.org/W2084948863","https://openalex.org/W2085555740","https://openalex.org/W2085738229","https://openalex.org/W2087668602","https://openalex.org/W2088194700","https://openalex.org/W2089031834","https://openalex.org/W2089168615","https://openalex.org/W2089743844","https://openalex.org/W2090347597","https://openalex.org/W2091019029","https://openalex.org/W2091108794","https://openalex.org/W2091435599","https://openalex.org/W2092073971","https://openalex.org/W2092094591","https://openalex.org/W2094031027","https://openalex.org/W2094464340","https://openalex.org/W2094595216","https://openalex.org/W2094601991","https://openalex.org/W2095419404","https://openalex.org/W2095847051","https://openalex.org/W2096234619","https://openalex.org/W2096301496","https://openalex.org/W2097034992","https://openalex.org/W2099433891","https://openalex.org/W2099552932","https://openalex.org/W2100213157","https://openalex.org/W2101970047","https://openalex.org/W2103861397","https://openalex.org/W2104074198","https://openalex.org/W2104397822","https://openalex.org/W2105053798","https://openalex.org/W2105278533","https://openalex.org/W2105673791","https://openalex.org/W2106248075","https://openalex.org/W2106336605","https://openalex.org/W2107720194","https://openalex.org/W2108235260","https://openalex.org/W2108765339","https://openalex.org/W2109216029","https://openalex.org/W2109747814","https://openalex.org/W2110021087","https://openalex.org/W2110390821","https://openalex.org/W2110722277","https://openalex.org/W2111220263","https://openalex.org/W2111943979","https://openalex.org/W2112166111","https://openalex.org/W2112282810","https://openalex.org/W2112284938","https://openalex.org/W2112601164","https://openalex.org/W2113119572","https://openalex.org/W2114123652","https://openalex.org/W2114394188","https://openalex.org/W2114443908","https://openalex.org/W2114769428","https://openalex.org/W2116195930","https://openalex.org/W2117475553","https://openalex.org/W2117515288","https://openalex.org/W2117683008","https://openalex.org/W2118797813","https://openalex.org/W2119532085","https://openalex.org/W2119906011","https://openalex.org/W2120015665","https://openalex.org/W2120040881","https://openalex.org/W2120121156","https://openalex.org/W2120194361","https://openalex.org/W2120280279","https://openalex.org/W2120294060","https://openalex.org/W2121009566","https://openalex.org/W2122096836","https://openalex.org/W2122668115","https://openalex.org/W2123708888","https://openalex.org/W2124150826","https://openalex.org/W2124190967","https://openalex.org/W2124325544","https://openalex.org/W2124838434","https://openalex.org/W2126058383","https://openalex.org/W2126246455","https://openalex.org/W2126604656","https://openalex.org/W2126995684","https://openalex.org/W2127788247","https://openalex.org/W2128287837","https://openalex.org/W2128471695","https://openalex.org/W2128991449","https://openalex.org/W2129203922","https://openalex.org/W2129482297","https://openalex.org/W2129630141","https://openalex.org/W2129973151","https://openalex.org/W2132743085","https://openalex.org/W2135049215","https://openalex.org/W2135703618","https://openalex.org/W2135858175","https://openalex.org/W2137319366","https://openalex.org/W2137781960","https://openalex.org/W2137879329","https://openalex.org/W2138677670","https://openalex.org/W2138816938","https://openalex.org/W2139605631","https://openalex.org/W2139759276","https://openalex.org/W2139841187","https://openalex.org/W2139859789","https://openalex.org/W2140206763","https://openalex.org/W2140279098","https://openalex.org/W2140789099","https://openalex.org/W2141317766","https://openalex.org/W2143752061","https://openalex.org/W2145159378","https://openalex.org/W2145426305","https://openalex.org/W2145466675","https://openalex.org/W2145736817","https://openalex.org/W2145818079","https://openalex.org/W2145825913","https://openalex.org/W2146011840","https://openalex.org/W2147022432","https://openalex.org/W2148143890","https://openalex.org/W2148655474","https://openalex.org/W2148695635","https://openalex.org/W2149057253","https://openalex.org/W2149431167","https://openalex.org/W2149789162","https://openalex.org/W2150872976","https://openalex.org/W2150923830","https://openalex.org/W2151295474","https://openalex.org/W2151640744","https://openalex.org/W2151962109","https://openalex.org/W2153684517","https://openalex.org/W2153717284","https://openalex.org/W2153838990","https://openalex.org/W2154328223","https://openalex.org/W2154537066","https://openalex.org/W2154772811","https://openalex.org/W2155723148","https://openalex.org/W2156013098","https://openalex.org/W2156242189","https://openalex.org/W2156354476","https://openalex.org/W2157082041","https://openalex.org/W2157882739","https://openalex.org/W2158372391","https://openalex.org/W2158692368","https://openalex.org/W2158939742","https://openalex.org/W2159475304","https://openalex.org/W2160881014","https://openalex.org/W2161868263","https://openalex.org/W2162203679","https://openalex.org/W2163860604","https://openalex.org/W2163981044","https://openalex.org/W2164447052","https://openalex.org/W2164494606","https://openalex.org/W2164498356","https://openalex.org/W2164613298","https://openalex.org/W2164793406","https://openalex.org/W2164866097","https://openalex.org/W2166650828","https://openalex.org/W2167360046","https://openalex.org/W2168020376","https://openalex.org/W2168935492","https://openalex.org/W2170851221","https://openalex.org/W2171174503","https://openalex.org/W2171369029","https://openalex.org/W2171436881","https://openalex.org/W2184533357","https://openalex.org/W2312832381","https://openalex.org/W2317145780","https://openalex.org/W2329476392","https://openalex.org/W2335364655","https://openalex.org/W2397165872","https://openalex.org/W4241937068","https://openalex.org/W4313333737"],"related_works":["https://openalex.org/W974815133","https://openalex.org/W1517625179","https://openalex.org/W2916642002","https://openalex.org/W4313351603","https://openalex.org/W2157882739","https://openalex.org/W4402307012","https://openalex.org/W207246335","https://openalex.org/W2771097613","https://openalex.org/W2152912310","https://openalex.org/W4386698858"],"abstract_inverted_index":{"We":[0,197],"first":[1],"show":[2,199],"that":[3,88,200],"the":[4,20,50,75,125,135,141,163,166,169,187,211,216,230,291,328,332,349],"intranasal":[5],"delivery":[6],"of":[7,63,127,134,145,168,213,285,334,345],"virus-like":[8],"particles":[9],"(VLPs),":[10],"which":[11,191],"bear":[12],"no":[13],"antigenic":[14],"similarities":[15],"to":[16,22,30,49,171,210,227,234,322,327,337],"respiratory":[17],"pathogens,":[18],"prime":[19],"lungs":[21,76,170],"facilitate":[23],"heightened":[24],"and":[25,43,60,71,77,94,112,124,148,159,189,238,240,301,310,314],"accelerated":[26,40,116,180,194,237,316],"primary":[27,182],"immune":[28,183,232],"responses":[29,36,150,184,243,273,313,317],"high-dose":[31],"influenza":[32,72],"virus":[33,73],"challenge.":[34],"These":[35],"were":[37,100,114,151,244,256,274],"characterized":[38],"by":[39,154,277],"CD103":[41],"+":[42,45,86,108],"CD11b":[44],"dendritic":[46,61],"cell":[47,97,110],"trafficking":[48],"local":[51],"tracheobronchial":[52],"lymph":[53],"node":[54],"(TBLN).":[55],"Furthermore,":[56],"both":[57,67,118,186],"alveolar":[58],"macrophages":[59],"cells":[62,87,158,161],"VLP-exposed":[64,128],"mice":[65,292],"processed":[66],"a":[68,91,201,250,259,281],"model":[69,202],"antigen,":[70,203],"in":[74,90,117,162,174,185,193,287],"TBLNs":[78,126],"significantly":[79,115],"earlier":[80],"than":[81],"controls.":[82],"Additionally,":[83,290],"VLP-primed":[84],"CD11c":[85],"trafficked":[89],"CCR2-dependent":[92],"manner,":[93],"upregulated":[95],"T":[96,109],"co-stimulatory":[98],"molecules":[99],"associated":[101],"with":[102,258,294],"enhanced":[103,142,175],"viral":[104,195],"clearance.":[105,196],"Influenza-specific":[106],"CD4":[107],"proliferation":[111],"activation":[113],"inducible":[119],"bronchus-associated":[120],"lymphoid":[121],"tissues":[122],"(iBALT)":[123],"mice.":[129,289],"Finally,":[130],"pulmonary":[131],"epithelial":[132],"expression":[133],"polymeric":[136],"Ig":[137],"receptor":[138],"allowed":[139],"for":[140,339,351],"luminal":[143],"presence":[144],"anti-influenza":[146],"antibody,":[147],"these":[149,315],"further":[152],"supported":[153],"germinal":[155],"center":[156],"B":[157],"TFH":[160],"lung.":[164],"Thus,":[165,306],"exposure":[167],"VLPs":[172,338],"resulted":[173,192],"antigen":[176,324],"processing":[177],"abilities,":[178],"causing":[179],"influenza-specific":[181],"iBALT":[188],"TBLNs,":[190],"next":[198],"ovalbumin":[204],"(OVA),":[205],"can":[206],"be":[207,320],"chemically":[208,325],"conjugated":[209,222,326],"exterior":[212],"our":[214],"VLP,":[215,261,330],"small":[217],"heat-shock":[218],"protein":[219],"(sHsp).":[220],"When":[221],"OVA-sHsp":[223,268],"was":[224,236],"delivered":[225],"intranasally":[226],"naive":[228],"mice,":[229],"resulting":[231],"response":[233],"OVA":[235],"intensified,":[239],"OVA-specific":[241,271,303],"IgG1":[242,272],"apparent":[245,275],"within":[246],"5":[247],"days":[248,279],"after":[249,280],"single":[251,282],"immunizing":[252,283],"dose.":[253],"If":[254],"animals":[255],"pretreated":[257,293],"disparate":[260],"P22":[262,295],"(a":[263],"non-replicative":[264],"bacteriophage":[265],"capsid),":[266],"before":[267],"conjugate":[269,286],"immunization,":[270],"already":[276],"4":[278],"dose":[284],"OVA-naive":[288],"produced":[296],"high":[297],"titer":[298],"mucosal":[299],"IgA,":[300],"isotype-switched":[302],"serum":[304],"IgG.":[305],"VLP-treatment":[307],"elicited":[308],"quick":[309],"intense":[311],"antibody":[312],"could":[318],"similarly":[319],"induced":[321],"an":[323],"sHsp":[329],"demonstrating":[331],"utility":[333],"conjugating":[335],"antigens":[336],"pre-,":[340],"or":[341],"possibly":[342],"post-exposure":[343],"prophylaxis":[344],"lung,":[346],"all":[347],"without":[348],"need":[350],"adjuvant.":[352]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
