{"id":"https://openalex.org/W6947598528","doi":"https://doi.org/10.3929/ethz-b-000704271","title":"Early-Life Adversities Are Associated With Lower Expected Value Signaling in the Adult Brain","display_name":"Early-Life Adversities Are Associated With Lower Expected Value Signaling in the Adult Brain","publication_year":2024,"publication_date":"2024-12-15","ids":{"openalex":"https://openalex.org/W6947598528","doi":"https://doi.org/10.3929/ethz-b-000704271"},"language":"en","primary_location":{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/704271","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/704271","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Psychiatry, 96 (12)","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/20.500.11850/704271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080016475","display_name":"Seda Sacu","orcid":"https://orcid.org/0000-0003-4734-9835","observed_orcids":["https://orcid.org/0000-0003-4734-9835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sacu, Seda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055765010","display_name":"Magda Dubois","orcid":"https://orcid.org/0000-0002-5396-1855","observed_orcids":["https://orcid.org/0000-0002-5396-1855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dubois, Magda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089972486","display_name":"Frank Hubert Hezemans","orcid":"https://orcid.org/0000-0003-0092-3289","observed_orcids":["https://orcid.org/0000-0003-0092-3289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hezemans, Frank H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Aggensteiner, Pascal-M.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aggensteiner, Pascal-M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109616833","display_name":"Maximilian Monninger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monninger, Maximilian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027904065","display_name":"Daniel Brandeis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brandeis, Daniel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016008616","display_name":"Tobias Banaschewski","orcid":"https://orcid.org/0000-0003-4595-1144","observed_orcids":["https://orcid.org/0000-0003-4595-1144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Banaschewski, Tobias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042016465","display_name":"Tobias U. Hauser","orcid":"https://orcid.org/0000-0002-7997-8137","observed_orcids":["https://orcid.org/0000-0002-7997-8137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hauser, Tobias U.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Holz, Nathalie E.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holz, Nathalie E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32105044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.04910000041127205,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-adversity","display_name":"childhood adversity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/reward-learning","display_name":"reward learning","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prediction-error","display_name":"prediction error","score":0.699999988079071},{"id":"https://openalex.org/keywords/reward-network","display_name":"reward network","score":0.4860000014305115},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":1.0},{"id":"https://openalex.org/keywords/anterior-cingulate-cortex","display_name":"anterior cingulate cortex","score":1.0},{"id":"https://openalex.org/keywords/maternal-stimulation","display_name":"maternal stimulation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/prenatal-stress","display_name":"prenatal stress","score":0.8450000286102295},{"id":"https://openalex.org/keywords/maternal-smoking","display_name":"maternal smoking","score":0.7440000176429749},{"id":"https://openalex.org/keywords/psychopathology","display_name":"psychopathology","score":0.8730000257492065},{"id":"https://openalex.org/keywords/withdrawal-symptoms","display_name":"withdrawal symptoms","score":0.6919999718666077},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9620000123977661},{"id":"https://openalex.org/keywords/decision-making","display_name":"decision-making","score":0.699999988079071},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/computational-neuroimaging","display_name":"computational neuroimaging","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47870001196861267},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3783999979496002},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2784000039100647},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.27619999647140503},{"id":"https://openalex.org/C26760741","wikidata":"https://www.wikidata.org/wiki/Q160402","display_name":"Perception","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C96851999","wikidata":"https://www.wikidata.org/wiki/Q848369","display_name":"Subconscious","level":3,"score":0.24729999899864197}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/704271","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/704271","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Psychiatry, 96 (12)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000704271","doi":"https://doi.org/10.3929/ethz-b-000704271","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000704271","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/704271","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/704271","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biological Psychiatry, 96 (12)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.47131532430648804,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Early":[1],"adverse":[2,226],"experiences":[3,227],"are":[4,28],"assumed":[5],"to":[6,32,112,177],"affect":[7],"fundamental":[8],"processes":[9],"of":[10,26,65,95,258],"reward":[11,66,156,238],"learning":[12,67,239],"and":[13,30,62,101,129,138,150,189,209,211,252],"decision":[14,250],"making.":[15],"However,":[16],"computational":[17,63],"neuroimaging":[18],"studies":[19,33],"investigating":[20],"these":[21],"circuits":[22],"in":[23,35,153,182,196,228,240],"the":[24,39,93,103,154,166,183,197,203,217,256],"context":[25,230],"adversity":[27,118,122,167,207],"sparse":[29],"limited":[31],"conducted":[34],"adolescent":[36],"samples,":[37],"leaving":[38],"long-term":[40,234],"effects":[41],"unexplored.":[42],"Methods:":[43],"Using":[44],"data":[45],"from":[46],"a":[47,80,108,233],"longitudinal":[48],"birth":[49],"cohort":[50],"study":[51],"(n":[52],"=":[53],"156;":[54],"87":[55],"female),":[56],"we":[57],"investigated":[58],"associations":[59],"between":[60,205],"adversities":[61,128],"markers":[64],"(i.e.,":[68],"expected":[69,179],"value,":[70],"prediction":[71],"errors).":[72],"At":[73],"age":[74],"33":[75],"years,":[76],"all":[77],"participants":[78],"completed":[79],"functional":[81,96],"magnetic":[82,97],"resonance":[83,98],"imaging\u2013based":[84],"passive":[85],"avoidance":[86],"task.":[87],"Psychopathology":[88],"measures":[89],"were":[90,146],"collected":[91],"at":[92],"time":[94],"imaging":[99],"investigation":[100],"during":[102,216],"COVID-19":[104,218],"pandemic.":[105,219],"We":[106,163],"applied":[107],"principal":[109],"component":[110],"analysis":[111],"capture":[113],"common":[114],"variations":[115],"across":[116],"7":[117],"measures.":[119],"The":[120],"resulting":[121],"factors":[123],"(factor":[124],"1:":[125],"postnatal":[126],"psychosocial":[127],"prenatal":[130,135],"maternal":[131,136,144,173],"smoking;":[132],"factor":[133,141],"2:":[134],"stress":[137],"obstetric":[139],"adversity;":[140],"3:":[142],"lower":[143,172,178],"stimulation)":[145],"linked":[147,176],"with":[148,248],"psychopathology":[149,210],"neural":[151],"responses":[152],"core":[155],"network":[157],"using":[158],"multiple":[159],"regression":[160],"analysis.":[161],"Results:":[162],"found":[164],"that":[165,224],"dimension":[168,208],"primarily":[169],"informed":[170],"by":[171],"stimulation":[174],"was":[175],"value":[180,194],"representation":[181],"right":[184,186,198],"putamen,":[185],"nucleus":[187,199],"accumbens,":[188],"anterior":[190],"cingulate":[191],"cortex.":[192],"Expected":[193],"encoding":[195],"accumbens":[200],"further":[201],"mediated":[202],"relationship":[204],"this":[206],"predicted":[212],"higher":[213],"withdrawn":[214],"symptoms":[215],"Conclusions:":[220],"Our":[221],"results":[222],"suggested":[223],"early":[225],"caregiver":[229],"might":[231],"have":[232],"disruptive":[235],"effect":[236],"on":[237],"reward-related":[241],"brain":[242],"regions,":[243],"which":[244],"can":[245],"be":[246],"associated":[247],"suboptimal":[249],"making":[251],"thereby":[253],"may":[254],"increase":[255],"vulnerability":[257],"developing":[259],"psychopathology.":[260]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
