{"id":"https://openalex.org/W69413864","doi":null,"title":"Effects of the combined action of roentgen rays and a chemical carcinogen (DAB) on the rat's liver.","display_name":"Effects of the combined action of roentgen rays and a chemical carcinogen (DAB) on the rat's liver.","publication_year":1962,"publication_date":"1962-03-01","ids":{"openalex":"https://openalex.org/W69413864","mag":"69413864","pmid":"https://pubmed.ncbi.nlm.nih.gov/14461344"},"language":"en","primary_location":{"id":"pmid:14461344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14461344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of roentgenology, radium therapy, and nuclear medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002973665","display_name":"A Lacassagne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A LACASSAGNE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113831478","display_name":"L Hurst","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L HURST","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.03721174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":null,"first_page":"536","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-rays","display_name":"X-rays","score":0.5289999842643738},{"id":"https://openalex.org/keywords/p-dimethylaminoazobenzene","display_name":"p-dimethylaminoazobenzene","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6449999809265137},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/compensatory-hypertrophy","display_name":"compensatory hypertrophy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/liver-atrophy","display_name":"liver atrophy","score":0.7839999794960022},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.5149999856948853},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6359999775886536},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7685495018959045},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7333377003669739},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.7179845571517944},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.543716549873352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4917464554309845},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.45899417996406555},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4229654371738434},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.41661933064460754},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41134709119796753},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3414834141731262},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2755478024482727},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17351838946342468},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09281089901924133},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011830","descriptor_name":"Radiation Effects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14461344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14461344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of roentgenology, radium therapy, and nuclear medicine","raw_type":"Journal Article"},{"id":"mag:69413864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14461344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2209907411","https://openalex.org/W2433632257","https://openalex.org/W236449468","https://openalex.org/W2083384083","https://openalex.org/W7145472069","https://openalex.org/W2211783843","https://openalex.org/W1547471396","https://openalex.org/W2029579899","https://openalex.org/W2399962381","https://openalex.org/W1828236295"],"abstract_inverted_index":{"The":[0,109],"effects":[1,10],"of":[2,5,11,15,22,33,87,92,96],"increasing":[3],"doses":[4,32],"x":[6],"rays":[7],"and":[8,18,35,57,117],"the":[9,12,53,72,75,85,93,100,104,112],"combined":[13],"action":[14,86],"ionizing":[16],"radiation":[17],"a":[19],"steady":[20],"diet":[21],"p-":[23],"dimethylaminoazobenzene":[24],"(DAB)":[25],"are":[26],"given.":[27],"It":[28],"was":[29,48,79,89],"found":[30],"that":[31,67,81],"500":[34],"1500":[36],"r":[37,47],"had":[38],"no":[39],"significant":[40],"effect":[41],"on":[42],"rats'":[43],"livers,":[44],"but":[45],"3000":[46],"not":[49,69,120],"well":[50],"tolerated.":[51],"With":[52],"3000-r":[54],"dose,":[55],"atropy":[56],"compensatory":[58],"hypertrophy":[59],"were":[60],"present":[61],"one":[62],"month":[63],"later":[64],"in":[65],"rats":[66],"did":[68,119],"succumb":[70],"to":[71,111,122],"dose.":[73],"In":[74],"second":[76],"experiment":[77],"it":[78],"concluded":[80],"malignant":[82],"transformation":[83],"under":[84],"DAB":[88,118],"retarded":[90],"because":[91],"possible":[94],"slackening":[95],"repair":[97],"processes":[98],"by":[99,115],"irradiation":[101,116],"which":[102],"preceded":[103],"chemically":[105],"induced":[106],"cancer":[107],"formation.":[108],"damage":[110],"hepatic":[113],"cells":[114],"appear":[121],"be":[123],"additive.":[124],"(P.C.H.)":[125]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
