{"id":"https://openalex.org/W69374983","doi":"https://doi.org/10.1097/nen.0b013e31822c62cf","title":"Accumulation of Transactive Response DNA Binding Protein 43 in Mild Cognitive Impairment and Alzheimer Disease","display_name":"Accumulation of Transactive Response DNA Binding Protein 43 in Mild Cognitive Impairment and Alzheimer Disease","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W69374983","doi":"https://doi.org/10.1097/nen.0b013e31822c62cf","mag":"69374983","pmid":"https://pubmed.ncbi.nlm.nih.gov/21865887","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3197017"},"language":"en","primary_location":{"id":"doi:10.1097/nen.0b013e31822c62cf","doi":"https://doi.org/10.1097/nen.0b013e31822c62cf","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0b013e31822c62cf","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3197017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022727147","display_name":"Cyntia Tremblay","orcid":"https://orcid.org/0000-0003-2522-517X","observed_orcids":["https://orcid.org/0000-0003-2522-517X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Cyntia Tremblay","raw_affiliation_strings":["Facult\u00e9 de pharmacie, Universit\u00e9 Laval and Centre Hospitalier de l'Universit\u00e9 Laval Research Center, Quebec, Canada","From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval and Centre Hospitalier de l'Universit\u00e9 Laval Research Center, Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006507252","display_name":"Isabelle St\u2010Amour","orcid":"https://orcid.org/0000-0003-2042-804X","observed_orcids":["https://orcid.org/0000-0003-2042-804X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Isabelle St-Amour","raw_affiliation_strings":["From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022605809","display_name":"Julie A. Schneider","orcid":"https://orcid.org/0000-0002-9482-1752","observed_orcids":["https://orcid.org/0000-0002-9482-1752"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Julie Schneider","raw_affiliation_strings":["From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014075642","display_name":"David Alan Bennett","orcid":"https://orcid.org/0000-0003-3689-554X","observed_orcids":["https://orcid.org/0000-0003-3689-554X"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"David A. Bennett","raw_affiliation_strings":["From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada; and Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005670129","display_name":"Fr\u00e9d\u00e9ric Calon","orcid":"https://orcid.org/0000-0002-4203-0887","observed_orcids":["https://orcid.org/0000-0002-4203-0887"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Fr\u00e9d\u00e9ric Calon","raw_affiliation_strings":["Centre Hospitalier de l'Universit\u00e9 Laval (CHUL) Research Center, QC, Canada","Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada","From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier de l'Universit\u00e9 Laval (CHUL) Research Center, QC, Canada","institution_ids":["https://openalex.org/I4210139308"]},{"raw_affiliation_string":"Facult\u00e9 de pharmacie, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"From the Facult\u00e9 de pharmacie, Universit\u00e9 Laval (CT, IS-A, FC) and Centre Hospitalier de l'Universit\u00e9 Laval Research Center (CT, IS-A, FC), Quebec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I43406934"]},{"raw_affiliation_string":"Rush Alzheimer's Disease Center (JS, DAB), Rush University Medical Center, Chicago, Illinois","institution_ids":["https://openalex.org/I1285301757"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005670129"],"corresponding_institution_ids":["https://openalex.org/I1285301757","https://openalex.org/I4210139308","https://openalex.org/I43406934"],"apc_list":{"value":5036,"currency":"USD","value_usd":5036},"apc_paid":null,"fwci":1.4977,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.77441002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"70","issue":"9","first_page":"788","last_page":"798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.9909999966621399},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":1.0},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7789999842643738},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8610000014305115},{"id":"https://openalex.org/keywords/paired-helical-filaments","display_name":"paired helical filaments","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cytoplasmic-inclusions","display_name":"cytoplasmic inclusions","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.8580126762390137},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.7544137239456177},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.5874816179275513},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.5863990783691406},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5564383864402771},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48859506845474243},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.4814395308494568},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.43747520446777344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42873552441596985},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39872419834136963},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38471144437789917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29962268471717834},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.29474082589149475},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.19875279068946838}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008609","descriptor_name":"Mental Status Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011180","descriptor_name":"Postmortem Changes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/nen.0b013e31822c62cf","doi":"https://doi.org/10.1097/nen.0b013e31822c62cf","is_oa":false,"landing_page_url":"https://doi.org/10.1097/nen.0b013e31822c62cf","pdf_url":null,"source":{"id":"https://openalex.org/S38023437","display_name":"Journal of Neuropathology & Experimental Neurology","issn_l":"0022-3069","issn":["0022-3069","1554-6578"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuropathology & Experimental Neurology","raw_type":"journal-article"},{"id":"pmid:21865887","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21865887","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuropathology and experimental neurology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2431732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3197017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3197017","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3197017/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neuropathol Exp Neurol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2431732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3197017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2988777808","display_name":null,"funder_award_id":"MOP102532","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4875156105","display_name":"Risk Factors, Pathology, and Clinical Expressions of AD","funder_award_id":"R01AG015819","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1511534554","https://openalex.org/W1542765837","https://openalex.org/W1554171816","https://openalex.org/W1562558820","https://openalex.org/W1593716627","https://openalex.org/W1619082318","https://openalex.org/W1646954254","https://openalex.org/W1964538957","https://openalex.org/W1966681419","https://openalex.org/W1967443709","https://openalex.org/W1972982304","https://openalex.org/W1973231428","https://openalex.org/W1974298458","https://openalex.org/W1977311503","https://openalex.org/W1984283611","https://openalex.org/W1985747467","https://openalex.org/W1989856924","https://openalex.org/W1991208268","https://openalex.org/W1993474946","https://openalex.org/W1995276702","https://openalex.org/W1997809912","https://openalex.org/W1999376988","https://openalex.org/W2000706612","https://openalex.org/W2002093269","https://openalex.org/W2003618511","https://openalex.org/W2005578478","https://openalex.org/W2008087702","https://openalex.org/W2009724146","https://openalex.org/W2010268863","https://openalex.org/W2011007124","https://openalex.org/W2014722859","https://openalex.org/W2019428673","https://openalex.org/W2020159880","https://openalex.org/W2021206757","https://openalex.org/W2022336636","https://openalex.org/W2028050242","https://openalex.org/W2031964319","https://openalex.org/W2041451000","https://openalex.org/W2044676388","https://openalex.org/W2045189928","https://openalex.org/W2048964557","https://openalex.org/W2052742260","https://openalex.org/W2053362200","https://openalex.org/W2055905297","https://openalex.org/W2057057871","https://openalex.org/W2064470441","https://openalex.org/W2065140753","https://openalex.org/W2067128590","https://openalex.org/W2067439875","https://openalex.org/W2075464796","https://openalex.org/W2077119043","https://openalex.org/W2081720711","https://openalex.org/W2092646825","https://openalex.org/W2093334504","https://openalex.org/W2094113864","https://openalex.org/W2102026369","https://openalex.org/W2104994835","https://openalex.org/W2115672510","https://openalex.org/W2117597459","https://openalex.org/W2125172225","https://openalex.org/W2126569879","https://openalex.org/W2131725903","https://openalex.org/W2134408741","https://openalex.org/W2136057227","https://openalex.org/W2145909463","https://openalex.org/W2152207212"],"related_works":["https://openalex.org/W1991949438","https://openalex.org/W2536360732","https://openalex.org/W206978487","https://openalex.org/W3022330814","https://openalex.org/W2154520196","https://openalex.org/W4200192644","https://openalex.org/W2147276396","https://openalex.org/W4385441981","https://openalex.org/W7161854594","https://openalex.org/W3113198890"],"abstract_inverted_index":{"Transactive":[0],"response":[1],"DNA":[2],"binding":[3],"protein":[4],"43":[5],"(TDP-43)":[6],"plays":[7],"a":[8,41],"central":[9],"role":[10],"in":[11,54,89,129,161,164,180],"the":[12,23,90,98,113,130,149,194],"neuropathology":[13],"of":[14,44,52,59,64,92,97,115,151,177,184,199],"frontotemporal":[15],"lobar":[16],"degeneration":[17],"and":[18,28,50,95,120,133,140,186,189,196],"amyotrophic":[19],"lateral":[20],"sclerosis,":[21],"but":[22],"relationship":[24],"between":[25],"TDP-43":[26,37,53,88,108,154,178],"abnormalities":[27,176],"Alzheimer":[29],"disease":[30],"(AD)":[31],"remains":[32],"unclear.":[33],"To":[34],"determine":[35],"whether":[36],"can":[38],"serve":[39],"as":[40],"neuropathologic":[42,197],"marker":[43],"AD,":[45,105],"we":[46],"performed":[47],"biochemical":[48],"characterization":[49],"quantification":[51],"homogenates":[55],"from":[56,137],"parietal":[57],"neocortex":[58],"subjects":[60],"with":[61,101,112,142,153,166,193],"aclinical":[62],"diagnosis":[63],"no":[65],"cognitive":[66,73,144],"impairment":[67,74],"(NCI,":[68],"n":[69,76],"=":[70,77,82],"12),":[71,78],"mild":[72],"(MCI,":[75],"or":[79,104,155],"AD":[80,138,162,187],"(n":[81],"12).":[83],"Immunoblots":[84],"revealed":[85],"increased":[86],"detergent-insoluble":[87],"cortex":[91],"0,":[93],"3,":[94],"6":[96],"12":[99],"individuals":[100,152],"NCI,":[102,165],"MCI,":[103],"respectively.":[106],"Detergent-insoluble":[107],"was":[109,127],"positively":[110],"correlated":[111,141],"accumulation":[114],"soluble":[116],"A\u03b242,":[117],"amyloid":[118],"plaques,":[119],"paired":[121],"helical":[122],"filamenttau.":[123],"In":[124],"contrast,":[125],"phospho-TDP-43":[126,156],"decreased":[128],"cytosolic":[131],"fraction":[132,136],"detergent-soluble":[134],"membrane/nuclear":[135],"patients":[139,188],"antemortem":[143],"function.Immunofluorescence":[145],"analysis":[146],"confirmed":[147],"that":[148,175,190],"frequencies":[150],"cytoplasmic":[157],"inclusions":[158],"were":[159],"higher":[160],"than":[163],"MCI":[167,185],"at":[168],"an":[169,181],"intermediate":[170],"level.":[171],"These":[172],"data":[173],"indicate":[174],"occur":[179],"important":[182],"subset":[183],"they":[191],"correlate":[192],"clinical":[195],"features":[198],"AD.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}