{"id":"https://openalex.org/W6929330617","doi":"https://doi.org/10.5167/uzh-275946","title":"A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis","display_name":"A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis","publication_year":2025,"publication_date":"2025-02-19","ids":{"openalex":"https://openalex.org/W6929330617","doi":"https://doi.org/10.5167/uzh-275946"},"language":"en","primary_location":{"id":"pmh:oai:www.zora.uzh.ch:275946","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Raia, Pierre; Lee, Kitaik; Bartsch, Simon M; Rico-Resendiz, Felix; Portugal-Calisto, Daniela; Vadas, Oscar; Panse, Vikram Govind; Fiedler, Dorothea; Hothorn, Michael (2025). A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. Nature Communications, 16(1):1753.","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070891945","display_name":"Pierre Raia","orcid":"https://orcid.org/0000-0003-3469-1922","observed_orcids":["https://orcid.org/0000-0003-3469-1922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raia, Pierre","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3469-1922","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Lee, Kitaik","orcid":"https://orcid.org/0000-0002-7761-5586","observed_orcids":["https://orcid.org/0000-0002-7761-5586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee, Kitaik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7761-5586","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045283360","display_name":"Simon M. Bartsch","orcid":"https://orcid.org/0000-0002-2215-7901","observed_orcids":["https://orcid.org/0000-0002-2215-7901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bartsch, Simon M","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2215-7901","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067926766","display_name":"Felix Rico-Res\u00e9ndiz","orcid":"https://orcid.org/0000-0003-0260-7298","observed_orcids":["https://orcid.org/0000-0003-0260-7298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rico-Resendiz, Felix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057393341","display_name":"Daniela Portugal-Calisto","orcid":"https://orcid.org/0000-0003-1591-5812","observed_orcids":["https://orcid.org/0000-0003-1591-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Portugal-Calisto, Daniela","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1591-5812","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006249493","display_name":"Oscar Vadas","orcid":"https://orcid.org/0000-0003-3511-6479","observed_orcids":["https://orcid.org/0000-0003-3511-6479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vadas, Oscar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3511-6479","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040502336","display_name":"Vikram Govind Panse","orcid":"https://orcid.org/0000-0002-4770-7068","observed_orcids":["https://orcid.org/0000-0002-4770-7068","https://orcid.org/0000-0001-7950-5746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Panse, Vikram Govind","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4770-7068","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008781299","display_name":"Dorothea Fiedler","orcid":"https://orcid.org/0000-0002-0798-946X","observed_orcids":["https://orcid.org/0000-0002-0798-946X","https://orcid.org/0000-0003-2990-4612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fiedler, Dorothea","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0798-946X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089590993","display_name":"Michael Hothorn","orcid":"https://orcid.org/0000-0002-3597-5698","observed_orcids":["https://orcid.org/0000-0002-3597-5698"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hothorn, Michael","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3597-5698","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33609911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12991","display_name":"Phytase and its Applications","score":0.48899999260902405,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.09189999848604202,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0786999985575676,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatase-domain","display_name":"phosphatase domain","score":0.8199999928474426},{"id":"https://openalex.org/keywords/inositol-pyrophosphates","display_name":"inositol pyrophosphates","score":0.9539999961853027},{"id":"https://openalex.org/keywords/phosphate-homeostasis","display_name":"phosphate homeostasis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gaf-domain","display_name":"GAF domain","score":0.6650000214576721},{"id":"https://openalex.org/keywords/zinc-binding-site","display_name":"zinc binding site","score":0.6959999799728394},{"id":"https://openalex.org/keywords/substrate-channel","display_name":"substrate channel","score":0.7039999961853027},{"id":"https://openalex.org/keywords/kinase-phosphatase-balance","display_name":"kinase-phosphatase balance","score":0.7210000157356262},{"id":"https://openalex.org/keywords/enzyme-crystal-structure","display_name":"enzyme crystal structure","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.8044000267982483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.616100013256073},{"id":"https://openalex.org/C2778905257","wikidata":"https://www.wikidata.org/wiki/Q1620721","display_name":"Histidine kinase","level":4,"score":0.6017000079154968},{"id":"https://openalex.org/C10522644","wikidata":"https://www.wikidata.org/wiki/Q24775216","display_name":"HAMP domain","level":4,"score":0.5687000155448914},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.5673999786376953},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5511999726295471},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5361999869346619},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5271000266075134},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5192999839782715},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.4668999910354614},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.4634999930858612},{"id":"https://openalex.org/C389152","wikidata":"https://www.wikidata.org/wiki/Q6593007","display_name":"Protein phosphatase 2","level":4,"score":0.43549999594688416},{"id":"https://openalex.org/C125209161","wikidata":"https://www.wikidata.org/wiki/Q422816","display_name":"Enzyme activator","level":3,"score":0.41690000891685486},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4043999910354614},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.39559999108314514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37950000166893005},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.37880000472068787},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.35370001196861267},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.34929999709129333},{"id":"https://openalex.org/C2776321633","wikidata":"https://www.wikidata.org/wiki/Q7187557","display_name":"Phosphoric monoester hydrolases","level":4,"score":0.34290000796318054},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.28380000591278076},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.26809999346733093},{"id":"https://openalex.org/C2780120296","wikidata":"https://www.wikidata.org/wiki/Q96286","display_name":"Hydrolase","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.2662000060081482},{"id":"https://openalex.org/C2780535078","wikidata":"https://www.wikidata.org/wiki/Q879954","display_name":"Sugar phosphates","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C97920573","wikidata":"https://www.wikidata.org/wiki/Q17915102","display_name":"DUSP6","level":5,"score":0.25870001316070557}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.zora.uzh.ch:275946","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Raia, Pierre; Lee, Kitaik; Bartsch, Simon M; Rico-Resendiz, Felix; Portugal-Calisto, Daniela; Vadas, Oscar; Panse, Vikram Govind; Fiedler, Dorothea; Hothorn, Michael (2025). A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. Nature Communications, 16(1):1753.","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5167/uzh-275946","doi":"https://doi.org/10.5167/uzh-275946","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-275946","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:www.zora.uzh.ch:275946","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/275946/1/ZORA275946.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Raia, Pierre; Lee, Kitaik; Bartsch, Simon M; Rico-Resendiz, Felix; Portugal-Calisto, Daniela; Vadas, Oscar; Panse, Vikram Govind; Fiedler, Dorothea; Hothorn, Michael (2025). A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis. Nature Communications, 16(1):1753.","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Inositol":[0],"pyrophosphates":[1],"(PP-InsPs)":[2],"are":[3],"eukaryotic":[4,147],"nutrient":[5],"messengers.":[6],"The":[7,27,67],"N-terminal":[8],"kinase":[9,14,30],"domain":[10,23,49,86,98],"of":[11,42,116,146],"diphosphoinositol":[12],"pentakisphosphate":[13],"(PPIP5K)":[15],"generates":[16],"the":[17,20,43,101,104,110,114,117,122,127,140],"messenger":[18],"1,5-InsP$_{8}$,":[19],"C-terminal":[21],"phosphatase":[22,32,48,61],"catalyzes":[24],"PP-InsP":[25],"breakdown.":[26],"balance":[28],"between":[29],"and":[31,45,75,94,132,144],"activities":[33],"regulates":[34],"1,5-InsP$_{8}$":[35,74],"levels.":[36],"Here,":[37],"we":[38],"present":[39],"crystal":[40],"structures":[41],"apo":[44],"substrate-bound":[46],"PPIP5K":[47,148],"from":[50],"S.":[51],"cerevisiae":[52],"(ScVip1$^{PD}$).":[53],"ScVip1$^{PD}$":[54],"is":[55,76],"a":[56,70,89,95],"phytase-like":[57],"inositol":[58],"1-pyrophosphate":[59],"histidine":[60],"with":[62],"two":[63],"conserved":[64],"catalytic":[65],"motifs.":[66],"enzyme":[68,128],"has":[69],"strong":[71],"preference":[72],"for":[73],"inhibited":[77],"by":[78,88],"inorganic":[79],"phosphate.":[80],"It":[81],"contains":[82],"an":[83],"\u03b1-helical":[84],"insertion":[85],"stabilized":[87],"structural":[90],"Zn$^{2+}$":[91],"binding":[92],"site,":[93,112],"unique":[96],"GAF":[97,118],"that":[99,108],"channels":[100],"substrate":[102,123],"to":[103],"active":[105,111],"site.":[106],"Mutations":[107],"alter":[109],"restrict":[113],"movement":[115],"domain,":[119],"or":[120],"change":[121],"channel\u2019s":[124],"charge":[125],"inhibit":[126],"activity":[129],"in":[130,135],"vitro,":[131],"Arabidopsis":[133],"VIH2":[134],"planta.":[136],"Our":[137],"work":[138],"reveals":[139],"structure,":[141],"enzymatic":[142],"mechanism":[143],"regulation":[145],"phosphatases.":[149]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
