{"id":"https://openalex.org/W69257189","doi":null,"title":"Altered antigenicity of keratan sulfate proteoglycan in selected corneal diseases.","display_name":"Altered antigenicity of keratan sulfate proteoglycan in selected corneal diseases.","publication_year":1990,"publication_date":"1990-03-01","ids":{"openalex":"https://openalex.org/W69257189","mag":"69257189","pmid":"https://pubmed.ncbi.nlm.nih.gov/2138589"},"language":"en","primary_location":{"id":"pmid:2138589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2138589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055977350","display_name":"James L. Funderburgh","orcid":"https://orcid.org/0000-0002-6192-6363","observed_orcids":["https://orcid.org/0000-0002-6192-6363"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Funderburgh","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111401331","display_name":"M.L. Funderburgh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M L Funderburgh","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102079792","display_name":"Merlyn M. Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M Rodrigues","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111797135","display_name":"Jay H. Krachmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Krachmer","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109922556","display_name":"G.W. Conrad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G W Conrad","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":null,"apc_paid":null,"fwci":4.0878,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.93256239,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"419","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratan-sulfate","display_name":"keratan sulfate","score":0.9319999814033508},{"id":"https://openalex.org/keywords/keratan-sulfate-proteoglycans","display_name":"keratan sulfate proteoglycan","score":0.8629999756813049},{"id":"https://openalex.org/keywords/corneal-disease","display_name":"corneal disease","score":0.7200000286102295},{"id":"https://openalex.org/keywords/keratoconus","display_name":"keratoconus","score":1.0},{"id":"https://openalex.org/keywords/pellucid-marginal-degeneration","display_name":"pellucid marginal degeneration","score":0.9980000257492065},{"id":"https://openalex.org/keywords/macular-corneal-dystrophy","display_name":"macular corneal dystrophy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8240000009536743},{"id":"https://openalex.org/keywords/immunofluorescence","display_name":"immunofluorescence","score":0.7200000286102295},{"id":"https://openalex.org/keywords/corneal-stroma","display_name":"corneal stroma","score":0.9559999704360962},{"id":"https://openalex.org/keywords/antigenicity","display_name":"antigenicity","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2778230131","wikidata":"https://www.wikidata.org/wiki/Q2457767","display_name":"Keratan sulfate","level":4,"score":0.9610844850540161},{"id":"https://openalex.org/C2778918178","wikidata":"https://www.wikidata.org/wiki/Q611984","display_name":"Keratoconus","level":3,"score":0.8529356122016907},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.6581884026527405},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6213183403015137},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.58458411693573},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5719141960144043},{"id":"https://openalex.org/C2778982777","wikidata":"https://www.wikidata.org/wiki/Q2044949","display_name":"Corneal dystrophy","level":3,"score":0.49880433082580566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43935665488243103},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.395228773355484},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21060612797737122},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.20240238308906555},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.1022939383983612}],"mesh":[{"descriptor_ui":"D000071234","descriptor_name":"Lumican","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003317","descriptor_name":"Corneal Dystrophies, Hereditary","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007632","descriptor_name":"Keratan Sulfate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007640","descriptor_name":"Keratoconus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2138589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2138589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:69257189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2138589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2111909822","display_name":"Fibroblast Differentiation During Eye Development","funder_award_id":"R01EY000952","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2081893922","https://openalex.org/W65838659","https://openalex.org/W27555609","https://openalex.org/W2146531209","https://openalex.org/W2147920354","https://openalex.org/W2124089530","https://openalex.org/W1968188000","https://openalex.org/W1970878966","https://openalex.org/W1986290968","https://openalex.org/W2091857468"],"abstract_inverted_index":{"Monoclonal":[0],"antibody":[1,44],"against":[2],"keratan":[3,201,216],"sulfate":[4,202,217],"(KS)":[5],"was":[6,65,78,103,124],"used":[7],"for":[8],"immunofluorescent":[9],"staining":[10,102,109,123,143,174],"of":[11,13,84,117,141,173,176,191,198,214],"sections":[12],"human":[14],"corneas":[15,49,59,98,151,179,205],"from":[16,206],"8":[17],"normal":[18,68,94,101,162],"eyes,":[19],"19":[20],"with":[21,24,29,36,50,99,189],"keratoconus,":[22,100],"4":[23],"pellucid":[25,73,136,148,209],"marginal":[26,74,137,149,210],"degeneration,":[27,211],"5":[28],"primary":[30,51],"macular":[31,38,52,85,220],"corneal":[32,39,53,86,221],"dystrophy,":[33,54],"and":[34,72,77,108,135,147,155,208,212],"1":[35],"recurrent":[37],"dystrophy.":[40,222],"The":[41,120],"anti-KS":[42],"monoclonal":[43],"did":[45],"not":[46,125],"stain":[47],"the":[48,106,113,118,133,177],"but":[55],"stained":[56],"all":[57],"other":[58],"to":[60,152],"varying":[61],"degrees.":[62],"Staining":[63],"intensity":[64,110,144],"weaker":[66],"than":[67,170],"in":[69,81,91,112,127,132,187,204,219],"most":[70],"keratoconus":[71,134,146,178,207],"degeneration":[75,138,150],"corneas,":[76,163],"very":[79],"weak":[80],"a":[82,92,164,181],"case":[83],"dystrophy":[87],"that":[88],"had":[89],"recurred":[90],"transplanted":[93],"cornea.":[95],"In":[96],"several":[97],"seen":[104],"at":[105],"periphery,":[107],"decreased":[111,121],"thinned":[114],"central":[115],"portion":[116],"stroma.":[119],"KS":[122],"localized":[126],"stromal":[128],"scar":[129],"tissue":[130],"found":[131,145],"corneas.":[139],"Quantitation":[140],"relative":[142],"be":[153],"49%":[154],"40%":[156],"as":[157,161],"intensely":[158],"stained,":[159],"respectively,":[160],"statistically":[165],"significant":[166],"decrease":[167],"(P":[168],"less":[169],"0.01).":[171],"Distribution":[172],"intensities":[175],"demonstrated":[180],"single":[182],"modality.":[183],"These":[184],"results":[185],"are":[186],"agreement":[188],"findings":[190],"previous":[192],"biochemical":[193],"studies,":[194],"which":[195],"show":[196],"reduction":[197],"highly":[199],"sulfated":[200,215],"epitopes":[203,218],"absence":[213]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}