{"id":"https://openalex.org/W69135234","doi":null,"title":"POST-TRA UMATIC SLEEP FOLLOWING DIFFUSE TRA UMATIC BRAIN IN JURY","display_name":"POST-TRA UMATIC SLEEP FOLLOWING DIFFUSE TRA UMATIC BRAIN IN JURY","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W69135234","mag":"69135234"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1006","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088889026","display_name":"Rachel K. Rowe","orcid":"https://orcid.org/0000-0002-9034-3159","observed_orcids":["https://orcid.org/0000-0002-9034-3159"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rachel K. Rowe","raw_affiliation_strings":["#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":"https://orcid.org/0000-0002-9034-3159","affiliations":[{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088889026"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00679486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.21739999949932098,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9210000038146973},{"id":"https://openalex.org/keywords/diffuse-brain-injury","display_name":"diffuse brain injury","score":0.734000027179718},{"id":"https://openalex.org/keywords/fluid-percussion-injury","display_name":"fluid percussion injury","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8190000057220459},{"id":"https://openalex.org/keywords/sleep-disruption","display_name":"sleep disruption","score":0.597000002861023},{"id":"https://openalex.org/keywords/neurological-recovery","display_name":"neurological recovery","score":0.578000009059906},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.7289999723434448},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.6359999775886536},{"id":"https://openalex.org/keywords/concussion","display_name":"concussion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/sleep-architecture","display_name":"sleep architecture","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.9376875162124634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6682978868484497},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.5573472380638123},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.4218199849128723},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.41142839193344116},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3921911120414734},{"id":"https://openalex.org/C2781210498","wikidata":"https://www.wikidata.org/wiki/Q1869874","display_name":"Insomnia","level":2,"score":0.30163562297821045},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1908589005470276},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1006","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},{"id":"mag:2292100795","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1006&context=neurobio_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:69135234","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1006&context=neurobio_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":276,"referenced_works":["https://openalex.org/W3028627","https://openalex.org/W5886163","https://openalex.org/W36950739","https://openalex.org/W37777227","https://openalex.org/W76456659","https://openalex.org/W84689042","https://openalex.org/W162285290","https://openalex.org/W183652139","https://openalex.org/W199598560","https://openalex.org/W414710620","https://openalex.org/W1419855764","https://openalex.org/W1480838305","https://openalex.org/W1480890041","https://openalex.org/W1490682840","https://openalex.org/W1497298414","https://openalex.org/W1508111780","https://openalex.org/W1510266002","https://openalex.org/W1520157167","https://openalex.org/W1521227715","https://openalex.org/W1523892186","https://openalex.org/W1542042755","https://openalex.org/W1545533518","https://openalex.org/W1550447348","https://openalex.org/W1556976316","https://openalex.org/W1574330564","https://openalex.org/W1579454106","https://openalex.org/W1672576559","https://openalex.org/W1707893729","https://openalex.org/W1728677071","https://openalex.org/W1806585896","https://openalex.org/W1829913204","https://openalex.org/W1905175420","https://openalex.org/W1914621113","https://openalex.org/W1925963981","https://openalex.org/W1944665321","https://openalex.org/W1962631311","https://openalex.org/W1963490521","https://openalex.org/W1964278471","https://openalex.org/W1965845779","https://openalex.org/W1965974639","https://openalex.org/W1966660293","https://openalex.org/W1966770838","https://openalex.org/W1967162115","https://openalex.org/W1968745677","https://openalex.org/W1969009328","https://openalex.org/W1969026212","https://openalex.org/W1969203830","https://openalex.org/W1969412681","https://openalex.org/W1970917906","https://openalex.org/W1971383788","https://openalex.org/W1971913131","https://openalex.org/W1972151202","https://openalex.org/W1972423968","https://openalex.org/W1972466031","https://openalex.org/W1973220557","https://openalex.org/W1973977212","https://openalex.org/W1974045191","https://openalex.org/W1974074735","https://openalex.org/W1975782323","https://openalex.org/W1975853067","https://openalex.org/W1978186585","https://openalex.org/W1978348024","https://openalex.org/W1979871716","https://openalex.org/W1981753157","https://openalex.org/W1982205031","https://openalex.org/W1982325600","https://openalex.org/W1983635597","https://openalex.org/W1984392358","https://openalex.org/W1984742490","https://openalex.org/W1985252982","https://openalex.org/W1988141317","https://openalex.org/W1988162831","https://openalex.org/W1988610853","https://openalex.org/W1989110124","https://openalex.org/W1989193081","https://openalex.org/W1990514899","https://openalex.org/W1990545071","https://openalex.org/W1990813290","https://openalex.org/W1991010754","https://openalex.org/W1991382015","https://openalex.org/W1995170778","https://openalex.org/W1996614758","https://openalex.org/W1997435185","https://openalex.org/W1997680764","https://openalex.org/W1998056500","https://openalex.org/W1998068393","https://openalex.org/W1999582871","https://openalex.org/W1999845971","https://openalex.org/W1999934730","https://openalex.org/W2000030536","https://openalex.org/W2000421692","https://openalex.org/W2000693195","https://openalex.org/W2003606001","https://openalex.org/W2004405382","https://openalex.org/W2005374086","https://openalex.org/W2005504069","https://openalex.org/W2005700669","https://openalex.org/W2006815671","https://openalex.org/W2007438633","https://openalex.org/W2008334217","https://openalex.org/W2008574207","https://openalex.org/W2008958086","https://openalex.org/W2009105636","https://openalex.org/W2009178440","https://openalex.org/W2009382150","https://openalex.org/W2010527958","https://openalex.org/W2011920011","https://openalex.org/W2012338377","https://openalex.org/W2012575744","https://openalex.org/W2013609330","https://openalex.org/W2014457069","https://openalex.org/W2014847319","https://openalex.org/W2015122191","https://openalex.org/W2015906010","https://openalex.org/W2016723726","https://openalex.org/W2018306768","https://openalex.org/W2018465654","https://openalex.org/W2019546770","https://openalex.org/W2019794759","https://openalex.org/W2019998186","https://openalex.org/W2022068824","https://openalex.org/W2022763266","https://openalex.org/W2023517019","https://openalex.org/W2024201248","https://openalex.org/W2024763628","https://openalex.org/W2025811337","https://openalex.org/W2025828188","https://openalex.org/W2026357988","https://openalex.org/W2027105684","https://openalex.org/W2027845732","https://openalex.org/W2028535633","https://openalex.org/W2028976687","https://openalex.org/W2030938312","https://openalex.org/W2031299209","https://openalex.org/W2031468337","https://openalex.org/W2031852804","https://openalex.org/W2032863300","https://openalex.org/W2034433299","https://openalex.org/W2035181561","https://openalex.org/W2035429585","https://openalex.org/W2035907179","https://openalex.org/W2037283540","https://openalex.org/W2037567458","https://openalex.org/W2038848909","https://openalex.org/W2040368069","https://openalex.org/W2043485493","https://openalex.org/W2044987694","https://openalex.org/W2045835312","https://openalex.org/W2045998740","https://openalex.org/W2047445016","https://openalex.org/W2049002034","https://openalex.org/W2049158024","https://openalex.org/W2049923824","https://openalex.org/W2050467552","https://openalex.org/W2050786936","https://openalex.org/W2050854467","https://openalex.org/W2051600991","https://openalex.org/W2053304919","https://openalex.org/W2054028677","https://openalex.org/W2054504556","https://openalex.org/W2056031482","https://openalex.org/W2056769976","https://openalex.org/W2057217973","https://openalex.org/W2058353483","https://openalex.org/W2059408557","https://openalex.org/W2060081813","https://openalex.org/W2060392742","https://openalex.org/W2060573807","https://openalex.org/W2061197367","https://openalex.org/W2061476401","https://openalex.org/W2062926546","https://openalex.org/W2063536480","https://openalex.org/W2063808715","https://openalex.org/W2064650404","https://openalex.org/W2065547297","https://openalex.org/W2066338529","https://openalex.org/W2067051297","https://openalex.org/W2067545381","https://openalex.org/W2067629356","https://openalex.org/W2068351868","https://openalex.org/W2069572398","https://openalex.org/W2070020404","https://openalex.org/W2070416004","https://openalex.org/W2074153094","https://openalex.org/W2075728714","https://openalex.org/W2075782105","https://openalex.org/W2076195318","https://openalex.org/W2076275094","https://openalex.org/W2076521166","https://openalex.org/W2077406427","https://openalex.org/W2079624058","https://openalex.org/W2079933139","https://openalex.org/W2080659194","https://openalex.org/W2081487927","https://openalex.org/W2081957132","https://openalex.org/W2083217606","https://openalex.org/W2084674974","https://openalex.org/W2087202696","https://openalex.org/W2087409544","https://openalex.org/W2088125540","https://openalex.org/W2088592819","https://openalex.org/W2088655509","https://openalex.org/W2088874382","https://openalex.org/W2089816012","https://openalex.org/W2090035193","https://openalex.org/W2090240067","https://openalex.org/W2090555468","https://openalex.org/W2090635612","https://openalex.org/W2092439208","https://openalex.org/W2092828502","https://openalex.org/W2093281755","https://openalex.org/W2094660330","https://openalex.org/W2095491556","https://openalex.org/W2095507597","https://openalex.org/W2097663158","https://openalex.org/W2100138491","https://openalex.org/W2103044571","https://openalex.org/W2103743177","https://openalex.org/W2109812447","https://openalex.org/W2109837753","https://openalex.org/W2110502877","https://openalex.org/W2113895559","https://openalex.org/W2114261191","https://openalex.org/W2116047361","https://openalex.org/W2117373688","https://openalex.org/W2118777827","https://openalex.org/W2119045494","https://openalex.org/W2120003285","https://openalex.org/W2121836743","https://openalex.org/W2122828560","https://openalex.org/W2123977622","https://openalex.org/W2124177697","https://openalex.org/W2128332802","https://openalex.org/W2128810790","https://openalex.org/W2133268982","https://openalex.org/W2135623011","https://openalex.org/W2138254752","https://openalex.org/W2141923055","https://openalex.org/W2144628640","https://openalex.org/W2145054010","https://openalex.org/W2145062984","https://openalex.org/W2146373526","https://openalex.org/W2147604161","https://openalex.org/W2147783395","https://openalex.org/W2151486654","https://openalex.org/W2151817454","https://openalex.org/W2153005893","https://openalex.org/W2157324785","https://openalex.org/W2158960911","https://openalex.org/W2159744238","https://openalex.org/W2160145375","https://openalex.org/W2161127400","https://openalex.org/W2161804899","https://openalex.org/W2163225965","https://openalex.org/W2164038707","https://openalex.org/W2165467410","https://openalex.org/W2171395319","https://openalex.org/W2188231788","https://openalex.org/W2188849278","https://openalex.org/W2228346480","https://openalex.org/W2240012954","https://openalex.org/W2286922506","https://openalex.org/W2287941853","https://openalex.org/W2290237204","https://openalex.org/W2317184793","https://openalex.org/W2328605528","https://openalex.org/W2398012102","https://openalex.org/W2399025129","https://openalex.org/W2399907169","https://openalex.org/W2416327412","https://openalex.org/W2423856317","https://openalex.org/W2433602230","https://openalex.org/W2478672379","https://openalex.org/W2736091234","https://openalex.org/W3142270006","https://openalex.org/W4406066835"],"related_works":["https://openalex.org/W1985252982","https://openalex.org/W2088655509","https://openalex.org/W2899813503","https://openalex.org/W1971383788","https://openalex.org/W2795130697","https://openalex.org/W2740065170","https://openalex.org/W3211324037","https://openalex.org/W4386925636","https://openalex.org/W6996539231","https://openalex.org/W1995572922"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,86,146],"injury":[2,40,147,153,176,182],"(TBI)":[3],"is":[4,94,313,329],"a":[5,311,337],"major":[6],"cause":[7],"of":[8,39,100,107,114,158,175,180,191,203,243,262,286,315],"death":[9],"and":[10,31,56,207,275,281,298,307],"disability":[11],"throughout":[12],"the":[13,37,53,98,105,132,156,192,201,316],"world":[14],"with":[15,28,45,216,288],"few":[16],"pharmacological":[17],"treatments":[18],"available":[19],"for":[20,171,341],"individuals":[21,73],"who":[22],"suffer":[23],"from":[24,319],"neurological":[25,43,58,108,234],"morbidities":[26],"associated":[27],"TBI.":[29,111,224,259],"Cellular":[30],"molecular":[32],"pathological":[33],"processes":[34],"initiated":[35],"at":[36,254],"time":[38,179],"develop":[41],"into":[42],"impairments,":[44],"chronic":[46,220],"sleep":[47,79,103,121,130,142,160,170,193,205,212,221,230,245,280,297,309,323],"disorders":[48],"(insomnia,":[49],"hypersomnolence)":[50],"being":[51],"among":[52],"somatic,":[54],"cognitive":[55],"emotional":[57],"impairments.":[59],"Immediately":[60],"post-injury,":[61],"TBI":[62,263],"patients":[63],"report":[64],"excessive":[65],"daytime":[66],"sleepiness,":[67],"however,":[68],"discordant":[69],"opinions":[70],"suggest":[71,308],"that":[72],"should":[74,81],"not":[75,247,264,325],"be":[76,82],"allowed":[77],"to":[78,96,118,154,233,334],"or":[80,178],"frequently":[83],"awoken":[84],"following":[85,144,222,344],"injury.":[87,320],"To":[88],"provide":[89],"adequate":[90],"medical":[91,267],"care,":[92],"it":[93,328],"imperative":[95],"understand":[97],"role":[99,348],"acute":[101,169,215],"post-traumatic":[102,120,159,211,229,240,244,279,296],"on":[104,278,295],"recovery":[106,318],"function":[109],"after":[110,122,236,257,310],"The":[112],"aim":[113],"this":[115],"thesis":[116],"was":[117,231],"examine":[119,155],"experimental":[123],"TBI,":[124],"defined":[125],"as":[126],"an":[127],"increase":[128],"in":[129,161,168,188,210,219,330,349],"during":[131],"first":[133],"hours":[134,173],"post-injury.":[135],"In":[136],"these":[137,302],"studies,":[138],"we":[139,226],"non-invasively":[140],"measured":[141],"activity":[143],"diffuse":[145,223,258],"induced":[148],"by":[149,238],"midline":[150],"fluid":[151],"percussion":[152],"architecture":[157],"mice.":[162],"We":[163,184,199],"detected":[164],"significant":[165],"injury-induced":[166],"increases":[167,187,209],"six":[172],"regardless":[174],"severity":[177],"day":[181],"occurred.":[183],"found":[185,208],"concurrent":[186],"cortical":[189],"levels":[190],"promoting":[194],"inflammatory":[195],"cytokine":[196],"interleukin":[197],"1-beta.":[198],"extended":[200],"timeline":[202],"post-injury":[204],"recording":[206],"are":[213],"distinctly":[214],"no":[217,331],"changes":[218],"Further,":[225],"investigated":[227,272],"if":[228],"beneficial":[232,333],"outcome":[235,250],"brain-injury":[237],"disrupting":[239,322],"sleep.":[241],"Disruption":[242],"did":[246],"worsen":[248,326],"functional":[249,282,299],"(neuromotor,":[251],"sensorimotor,":[252],"cognition)":[253],"one":[255],"week":[256],"With":[260],"sufferers":[261],"always":[265],"seeking":[266],"attention,":[268],"our":[269],"final":[270],"studies":[271,303],"over-the-counter":[273],"analgesics":[274,287],"their":[276],"effect":[277,294],"outcome.":[283,300,352],"Acute":[284],"administration":[285],"varying":[289],"anti-inflammatory":[290],"properties":[291],"had":[292],"little":[293,347],"Overall,":[301],"demonstrated":[304],"translational":[305],"potential":[306],"concussion":[312,345],"part":[314],"natural":[317],"While":[321],"does":[324],"outcome,":[327],"way":[332],"recovery.":[335],"Additionally,":[336],"single":[338],"analgesic":[339],"dose":[340],"pain":[342],"management":[343],"plays":[346],"short":[350],"term":[351]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}