{"id":"https://openalex.org/W6913045007","doi":"https://doi.org/10.5281/zenodo.8157794","title":"Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands","display_name":"Radiation-Induced Changes in Energy Metabolism Result in Mitochondrial Dysfunction in Salivary Glands","publication_year":2023,"publication_date":"2023-09-25","ids":{"openalex":"https://openalex.org/W6913045007","doi":"https://doi.org/10.5281/zenodo.8157794"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.8157794","doi":"https://doi.org/10.5281/zenodo.8157794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.8157794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.8157794","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033909972","display_name":"Lauren G. Buss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buss, Lauren G","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066799480","display_name":"Brenna A. Rheinheimer","orcid":"https://orcid.org/0000-0001-9461-4967","observed_orcids":["https://orcid.org/0000-0001-9461-4967"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rheinheimer, Brenna A","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070270181","display_name":"Kirsten H. Limesand","orcid":"https://orcid.org/0000-0003-4295-4665","observed_orcids":["https://orcid.org/0000-0003-4295-4665"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limesand, Kirsten H","raw_affiliation_strings":["University of Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":0.1661,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4858515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.6636000275611877,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.9639999866485596},{"id":"https://openalex.org/keywords/energy-metabolism-reprogramming","display_name":"energy metabolism reprogramming","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/salivary-gland-acinar-cells","display_name":"salivary acinar cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/glycolytic-flux","display_name":"glycolytic flux","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.8230000138282776},{"id":"https://openalex.org/keywords/extracellular-acidification","display_name":"extracellular acidification","score":0.8659999966621399},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.843999981880188},{"id":"https://openalex.org/keywords/spare-respiratory-capacity","display_name":"spare respiratory capacity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/head-and-neck-radiotherapy","display_name":"head and neck radiotherapy","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.641700029373169},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.5701000094413757},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5619000196456909},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.554099977016449},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5432000160217285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5331000089645386},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.5145999789237976},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4952999949455261},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.4634999930858612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4607999920845032},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3862999975681305},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.353300005197525},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34150001406669617},{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.33709999918937683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3343999981880188},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33410000801086426},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C55885012","wikidata":"https://www.wikidata.org/wiki/Q4750801","display_name":"Anaerobic glycolysis","level":4,"score":0.31200000643730164},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.2919999957084656},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.2831999957561493},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C66517615","wikidata":"https://www.wikidata.org/wiki/Q912751","display_name":"Cellular respiration","level":3,"score":0.2750999927520752},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2653999924659729}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.8157794","doi":"https://doi.org/10.5281/zenodo.8157794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.8157794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.8157795","doi":"https://doi.org/10.5281/zenodo.8157795","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.8157795","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.8157794","doi":"https://doi.org/10.5281/zenodo.8157794","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.8157794","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361021373","https://openalex.org/W6968349919","https://openalex.org/W7067666360","https://openalex.org/W3126517272","https://openalex.org/W4377134037","https://openalex.org/W6931803401","https://openalex.org/W3142820357","https://openalex.org/W4388979196","https://openalex.org/W4386478909","https://openalex.org/W4399129644"],"abstract_inverted_index":{"Salivary":[0],"glands":[1,150,188],"are":[2],"indirectly":[3],"damaged":[4],"during":[5],"radiotherapy":[6],"for":[7,20,45,64],"head":[8],"and":[9,15,56,88,97,117,123,144,158,168],"neck":[10],"cancer,":[11],"resulting":[12],"in":[13,54,74,78,112,139,154,160,181],"acute":[14,122],"chronic":[16,130,193],"hyposalivation.":[17],"Current":[18],"treatments":[19],"radiation-induced":[21],"hyposalivation":[22],"do":[23],"not":[24],"permanently":[25],"restore":[26],"function":[27,196],"to":[28,41,60,82,110],"the":[29,36,192],"gland;":[30],"therefore,":[31],"more":[32],"mechanistic":[33],"understanding":[34,71],"of":[35,72,101,185,195],"damage":[37],"response":[38],"is":[39,69,135],"needed":[40],"identify":[42],"therapeutic":[43],"targets":[44],"lasting":[46],"restoration.":[47],"Energy":[48],"metabolism":[49,76,183],"reprogramming":[50,77,184],"has":[51],"been":[52],"observed":[53],"cancer":[55],"wound":[57],"healing":[58],"models":[59],"provide":[61],"necessary":[62],"fuel":[63,99],"cell":[65],"proliferation;":[66],"however,":[67],"there":[68,134],"limited":[70],"alterations":[73],"energy":[75,182],"tissues":[79],"that":[80,189],"fail":[81],"heal.":[83],"We":[84],"measured":[85],"extracellular":[86],"acidification":[87],"oxygen":[89],"consumption":[90],"rates,":[91],"assessed":[92],"mitochondrial":[93,161,173],"DNA":[94,162],"copy":[95,163],"number,":[96],"tested":[98],"dependency":[100],"irradiated":[102,186],"primary":[103],"salivary":[104,149,187],"acinar":[105],"cells.":[106],"Radiation":[107],"treatment":[108],"leads":[109],"increases":[111,159],"glycolytic":[113,140],"flux,":[114,141],"oxidative":[115,142],"phosphorylation,":[116,143],"ATP":[118,145],"production":[119,146],"rate":[120],"at":[121,129,165],"intermediate":[124],"time":[125,132],"points.":[126],"In":[127],"contrast,":[128],"radiation":[131],"points":[133],"a":[136,172],"significant":[137,152],"decrease":[138],"rate.":[147],"Irradiated":[148],"exhibit":[151],"decreases":[153],"spare":[155],"respiratory":[156],"capacity":[157],"number":[164],"days":[166],"5":[167],"30":[169],"post-treatment,":[170],"suggesting":[171],"dysfunction":[174],"phenotype.":[175,197],"These":[176],"results":[177],"elucidate":[178],"kinetic":[179],"changes":[180],"may":[190],"underscore":[191],"loss":[194]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
