{"id":"https://openalex.org/W6903069747","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999","title":"Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses","display_name":"Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W6903069747","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999"},"language":"en","primary_location":{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/1e7ac090-1eb0-4ea1-87cd-a954a118beb1","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/1e7ac090-1eb0-4ea1-87cd-a954a118beb1","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"de Leeuw, W J, Dierssen, J, Vasen, H F, Wijnen, J T, Kenter, G G, Meijers-Heijboer, H, Brocker-Vriends, A, Stormorken, A, Moller, P, Menko, F, Cornelisse, C J & Morreau, H 2000, 'Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients', Journal of pathology, vol. 192, no. 3, pp. 328-335. https://doi.org/10.1002/1096-9896(2000)9999:9999","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111551860","display_name":"W J de Leeuw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"de Leeuw, W. J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146330168","display_name":"J. Dierssen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dierssen, J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010756339","display_name":"Hans F. A. Vasen","orcid":"https://orcid.org/0000-0003-2682-2603","observed_orcids":["https://orcid.org/0000-0003-2682-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vasen, H. F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127388472","display_name":"J.T. Wijnen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wijnen, J. T.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085925712","display_name":"Gemma G. Kenter","orcid":"https://orcid.org/0000-0002-7284-3918","observed_orcids":["https://orcid.org/0000-0002-7284-3918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenter, G. G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076448508","display_name":"Hanne E.J. Meijers-Heijboer","orcid":"https://orcid.org/0000-0003-1169-3853","observed_orcids":["https://orcid.org/0000-0003-1169-3853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meijers-Heijboer, H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146311851","display_name":"A. Brocker-Vriends","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brocker-Vriends, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072493355","display_name":"Astrid Tenden Stormorken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stormorken, A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089598316","display_name":"P\u00e5l M\u00f8ller","orcid":"https://orcid.org/0000-0001-8211-8237","observed_orcids":["https://orcid.org/0000-0001-8211-8237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moller, P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067697862","display_name":"Fred H. Menko","orcid":"https://orcid.org/0000-0001-5475-3241","observed_orcids":["https://orcid.org/0000-0001-5475-3241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Menko, F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146359543","display_name":"C. J. Cornelisse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cornelisse, C. J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5146392889","display_name":"H. Morreau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morreau, H.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.38386724,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13657","display_name":"Aortic Thrombus and Embolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lymphoid-follicles","display_name":"lymphoid follicles","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mucosa-associated-lymphoid-tissue","display_name":"mucosa-associated lymphoid tissue","score":0.9359999895095825},{"id":"https://openalex.org/keywords/aortic-plaque","display_name":"aortic plaque","score":0.7089999914169312},{"id":"https://openalex.org/keywords/b-cell-maturation","display_name":"B cell maturation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cd45ro-t-cells","display_name":"CD45RO+ memory T cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.753000020980835},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7200000286102295},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.9010000228881836},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.6425999999046326},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5746999979019165},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.5565999746322632},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.5335999727249146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5292999744415283},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48539999127388},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4442000091075897},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38440001010894775},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.33880001306533813},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.3122999966144562},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3025999963283539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2946999967098236},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.29120001196861267},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C3019684167","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignant cells","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25940001010894775},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2554999887943268}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/1e7ac090-1eb0-4ea1-87cd-a954a118beb1","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/1e7ac090-1eb0-4ea1-87cd-a954a118beb1","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"de Leeuw, W J, Dierssen, J, Vasen, H F, Wijnen, J T, Kenter, G G, Meijers-Heijboer, H, Brocker-Vriends, A, Stormorken, A, Moller, P, Menko, F, Cornelisse, C J & Morreau, H 2000, 'Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients', Journal of pathology, vol. 192, no. 3, pp. 328-335. https://doi.org/10.1002/1096-9896(2000)9999:9999","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/de913d52-314d-4c6b-9936-08ba887d9d71","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/de913d52-314d-4c6b-9936-08ba887d9d71","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Houtkamp, M A, de Boer, O J, van der Loos, C M, van der Wal, A C & Becker, A E 2001, 'Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responses', Journal of pathology, vol. 193, no. 2, pp. 263-269. https://doi.org/10.1002/1096-9896(2000)9999:9999","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/0e604526-e2a9-407a-b268-374de3456855","doi":"https://doi.org/10.1002/1096-9896(2000)9999:9999","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/0e604526-e2a9-407a-b268-374de3456855","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Van Grieken, N C T, Weiss, M M, Meijer, G A, Hermsen, M A J A, Scholte, G H A, Lindeman, J, Craanen, M E, Bloemena, E, Meuwissen, S G M, Baak, J P A & Kuipers, E J 2000, 'Helicobacter pylori-related and -non-related gastric cancers do not differ with respect to chromosomal aberrations', Journal of pathology, vol. 192, no. 3, pp. 301-306. https://doi.org/10.1002/1096-9896(2000)9999:9999","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144019380","https://openalex.org/W1985981007","https://openalex.org/W2186019492","https://openalex.org/W2110947961","https://openalex.org/W2072691048","https://openalex.org/W3173281583","https://openalex.org/W53807693","https://openalex.org/W4408250907","https://openalex.org/W1991581154","https://openalex.org/W2081399826"],"abstract_inverted_index":{"Advanced":[0],"atherosclerotic":[1,64,123,203],"lesions":[2],"often":[3],"contain":[4,10],"adventitial":[5,52,126,198],"lymphoid":[6,14,37,74,129,199],"infiltrates,":[7],"which":[8],"occasionally":[9],"nodular":[11,133],"aggregates":[12],"resembling":[13,128],"follicles.":[15,130],"The":[16,98,131,170],"structural":[17],"organization":[18],"suggests":[19],"that":[20],"local":[21,209],"maturation":[22],"of":[23,51,58,62,107,120,137,158,211,226,234],"B":[24,82,139],"cells":[25,143,159,176],"may":[26],"take":[27],"place":[28],"at":[29],"these":[30],"sites,":[31],"as":[32,77,94,114,232],"described":[33],"for":[34,69,73],"the":[35,46,59,105,121],"mucosa-associated":[36],"tissue":[38,228],"(MALT).":[39],"This":[40,191],"concept":[41],"was":[42,92,101],"evaluated":[43],"by":[44,168,220],"studying":[45],"micro-anatomy":[47],"and":[48,88,116,150,166,177,206,230],"cellular":[49,70],"composition":[50],"infiltrates":[53,127,200],"associated":[54],"with":[55,186],"advanced":[56,202,235],"atherosclerosis":[57,236],"aorta.":[60],"Sections":[61],"22":[63,122],"aortas":[65,124],"were":[66,135,160,164,182],"stained":[67],"immunohistochemically":[68],"markers":[71],"characteristic":[72],"follicles,":[75],"such":[76],"HECA-452-positive":[78,178],"endothelial":[79],"cells,":[80,83,87,140],"CD20-positive":[81],"CD21-positive":[84],"follicular":[85,141],"dendritic":[86,142],"CD68-positive":[89],"macrophages.":[90,169],"Ki-67":[91],"used":[93,102],"a":[95,145,194,212,224],"proliferation":[96],"marker.":[97],"TUNEL":[99],"technique":[100],"to":[103,217],"study":[104,192],"presence":[106],"apoptotic":[108,162],"cells.":[109],"Specimens":[110,185],"containing":[111],"MALT":[112,187],"served":[113],"comparison":[115],"positive":[117],"controls.":[118],"Seven":[119],"contained":[125,173],"organized":[132],"centres":[134],"composed":[136],"CD45RA+":[138],"(CD21+),":[144],"few":[146],"T":[147,175],"lymphocytes":[148],"(CD3+)":[149],"'tingible":[151],"body'":[152],"macrophages":[153],"(CD68+).":[154],"A":[155],"large":[156],"number":[157],"Ki-67-positive;":[161],"bodies":[163],"numerous":[165],"phagocytosed":[167],"parafollicular":[171],"area":[172],"CD45RO-positive":[174],"vessels.":[179],"Vessels":[180],"elsewhere":[181],"always":[183],"HECA-452-negative.":[184],"showed":[188],"similar":[189],"features.":[190],"reveals":[193],"close":[195],"resemblance":[196],"between":[197],"in":[201],"aortic":[204],"disease":[205],"MALT,":[207],"suggesting":[208],"generation":[210],"humoral":[213],"immune":[214],"response,":[215],"likely":[216],"be":[218],"initiated":[219],"antigens":[221],"released":[222],"during":[223],"process":[225],"long-standing":[227],"injury":[229],"inflammation":[231],"part":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}