{"id":"https://openalex.org/W68993272","doi":"https://doi.org/10.1007/978-1-60327-058-8_23","title":"Protein Crystallization in Restricted Geometry: Advancing Old Ideas for Modern Times in Structural Proteomics","display_name":"Protein Crystallization in Restricted Geometry: Advancing Old Ideas for Modern Times in Structural Proteomics","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W68993272","doi":"https://doi.org/10.1007/978-1-60327-058-8_23","mag":"68993272","pmid":"https://pubmed.ncbi.nlm.nih.gov/18542876"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60327-058-8_23","doi":"https://doi.org/10.1007/978-1-60327-058-8_23","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-058-8_23","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2399364539","display_name":"Structural Proteomics"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111785727","display_name":"Joseph D. Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1287610024","display_name":"Hauptman-Woodward Medical Research Institute","ror":"https://ror.org/02e1cpg76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1287610024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Ng","raw_affiliation_strings":["Hauptman-Woodward Medical Research Institute, Buffalo, NY, USA","Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hauptman-Woodward Medical Research Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1287610024"]},{"raw_affiliation_string":"Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1287610024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017648766","display_name":"Raymond C. Stevens","orcid":"https://orcid.org/0000-0002-4522-8725","observed_orcids":["https://orcid.org/0000-0002-4522-8725"]},"institutions":[{"id":"https://openalex.org/I1287610024","display_name":"Hauptman-Woodward Medical Research Institute","ror":"https://ror.org/02e1cpg76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1287610024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond C. Stevens","raw_affiliation_strings":["Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1287610024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000472988","display_name":"Peter K\u00fchn","orcid":"https://orcid.org/0000-0003-2629-4505","observed_orcids":["https://orcid.org/0000-0003-2629-4505"]},"institutions":[{"id":"https://openalex.org/I1287610024","display_name":"Hauptman-Woodward Medical Research Institute","ror":"https://ror.org/02e1cpg76","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1287610024"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Kuhn","raw_affiliation_strings":["Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hauptman-Woodward Medical Research Institute, Buffalo, New York, USA","institution_ids":["https://openalex.org/I1287610024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1287610024"],"apc_list":null,"apc_paid":null,"fwci":3.9537,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.9344653,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"426","issue":null,"first_page":"363","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"protein crystallization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/restricted-geometry","display_name":"restricted geometry","score":0.8450000286102295},{"id":"https://openalex.org/keywords/structural-genomics","display_name":"structural genomics","score":0.8349999785423279},{"id":"https://openalex.org/keywords/crystal-growth-optimization","display_name":"crystal growth optimization","score":0.5299999713897705},{"id":"https://openalex.org/keywords/miniaturization","display_name":"miniaturization","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C153064111","wikidata":"https://www.wikidata.org/wiki/Q1281033","display_name":"Protein crystallization","level":3,"score":0.8017021417617798},{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.7439370155334473},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.6276708841323853},{"id":"https://openalex.org/C192772702","wikidata":"https://www.wikidata.org/wiki/Q2583975","display_name":"Structural genomics","level":3,"score":0.5067461133003235},{"id":"https://openalex.org/C200447597","wikidata":"https://www.wikidata.org/wiki/Q334104","display_name":"Supersaturation","level":2,"score":0.4903550148010254},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44765034317970276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4262164235115051},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4261443614959717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39136847853660583},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.37347519397735596},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33780914545059204},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2599744200706482},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24160051345825195},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.1736074686050415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0969063937664032},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-60327-058-8_23","doi":"https://doi.org/10.1007/978-1-60327-058-8_23","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60327-058-8_23","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:18542876","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18542876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4824391660","display_name":null,"funder_award_id":"GM073197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6281797270","display_name":"JCIMPT-Complexes","funder_award_id":"P50GM073197","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W45836587","https://openalex.org/W600712839","https://openalex.org/W1503807176","https://openalex.org/W1539796472","https://openalex.org/W1540175722","https://openalex.org/W1871343740","https://openalex.org/W1971983296","https://openalex.org/W1976477725","https://openalex.org/W1991308549","https://openalex.org/W1993963235","https://openalex.org/W1998331486","https://openalex.org/W2010108435","https://openalex.org/W2015982647","https://openalex.org/W2017697736","https://openalex.org/W2020068704","https://openalex.org/W2027468035","https://openalex.org/W2049519154","https://openalex.org/W2063275954","https://openalex.org/W2070396536","https://openalex.org/W2078863041","https://openalex.org/W2078920376","https://openalex.org/W2081550483","https://openalex.org/W2082804080","https://openalex.org/W2090471855","https://openalex.org/W2093660390","https://openalex.org/W2094504398","https://openalex.org/W2098512408","https://openalex.org/W2107757176","https://openalex.org/W2116435022","https://openalex.org/W2117239890","https://openalex.org/W2129848443","https://openalex.org/W2130214618","https://openalex.org/W2144940319","https://openalex.org/W2147473535","https://openalex.org/W2159944520"],"related_works":["https://openalex.org/W2142838328","https://openalex.org/W2147473535","https://openalex.org/W4409625140","https://openalex.org/W2169614634","https://openalex.org/W1967499250","https://openalex.org/W1975247727","https://openalex.org/W2027468035","https://openalex.org/W7095695188","https://openalex.org/W2039077964","https://openalex.org/W3163232381"],"abstract_inverted_index":{"In":[0],"the":[1,49,122,167],"structural":[2,173],"genomics":[3],"period":[4],"traditional":[5,66],"methods":[6,58,73],"for":[7,25,102,150,166,172],"protein":[8,26,114],"crystallization":[9,104,108],"have":[10,38],"been":[11,39],"eclipsed":[12],"by":[13,45,91],"automation":[14,171],"using":[15],"batch":[16],"or":[17],"vapor":[18],"diffusion":[19],"equilibration":[20],"to":[21,99,112,126,162],"find":[22],"conditions":[23],"conducive":[24],"crystal":[27,137],"growth.":[28],"Although":[29],"many":[30],"globular":[31],"and":[32,41,56,61,65,86,106,143,157],"soluble":[33],"proteins":[34,52],"predominantly":[35],"from":[36],"prokaryotes":[37],"crystallized":[40],"their":[42],"structures":[43],"solved":[44],"high":[46],"throughput":[47],"approaches,":[48],"remaining":[50],"difficult":[51],"require":[53],"more":[54],"systematic":[55],"reflective":[57],"combining":[59],"miniaturization":[60],"integration":[62],"of":[63,70,134,170],"modern":[64],"crystallography":[67,152],"techniques.":[68],"One":[69],"these":[71],"conventional":[72],"is":[74,81,125],"growing":[75],"crystals":[76,115],"in":[77,116,121,139,145],"restricted":[78],"geometry,":[79],"which":[80],"a":[82,87,131,140],"historically":[83],"well-known":[84],"concept":[85],"practical":[88,97],"technique":[89],"under-used":[90],"today's":[92],"crystallographers.":[93],"This":[94],"chapter":[95],"presents":[96],"guidelines":[98],"use":[100],"capillaries":[101],"microbatch":[103],"screening":[105,129],"counter-diffusion":[107],"as":[109],"valuable":[110],"techniques":[111],"obtain":[113],"confined":[117],"volumes.":[118],"The":[119],"emphasis":[120],"authors'":[123],"application":[124],"perform":[127],"broad-based":[128],"with":[130],"microgram":[132],"amount":[133],"protein,":[135],"optimize":[136],"growth":[138],"supersaturation":[141],"gradient,":[142],"undergo":[144],"situ":[146],"x-ray":[147,151],"data":[148],"analysis":[149],"without":[153],"invasive":[154],"manipulation.":[155],"Applications":[156],"concepts":[158],"presented":[159],"here":[160],"bring":[161],"light":[163],"future":[164],"prerequisites":[165],"next":[168],"generation":[169],"genomics.":[174]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
