{"id":"https://openalex.org/W68989059","doi":"https://doi.org/10.1176/ajp.150.8.1158","title":"Anger attacks in unipolar depression, Part 1: Clinical correlates and response to fluoxetine treatment","display_name":"Anger attacks in unipolar depression, Part 1: Clinical correlates and response to fluoxetine treatment","publication_year":1993,"publication_date":"1993-08-01","ids":{"openalex":"https://openalex.org/W68989059","doi":"https://doi.org/10.1176/ajp.150.8.1158","mag":"68989059","pmid":"https://pubmed.ncbi.nlm.nih.gov/7848377"},"language":"en","primary_location":{"id":"doi:10.1176/ajp.150.8.1158","doi":"https://doi.org/10.1176/ajp.150.8.1158","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.150.8.1158","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W68989059"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084024326","display_name":"Maurizio Fava M. D","orcid":"https://orcid.org/0000-0002-4635-0458","observed_orcids":["https://orcid.org/0000-0002-4635-0458"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Fava","raw_affiliation_strings":["Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111986190","display_name":"Jerrold F. Rosenbaum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Rosenbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150851","display_name":"Joel A. Pava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J A Pava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017042640","display_name":"Mary K. McCarthy","orcid":"https://orcid.org/0009-0008-5479-982X","observed_orcids":["https://orcid.org/0009-0008-5479-982X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M K McCarthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113461316","display_name":"Ron Steingard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Steingard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055543840","display_name":"Evan Bouffides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bouffides","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.0341,"has_fulltext":false,"cited_by_count":233,"citation_normalized_percentile":{"value":0.98463774,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"150","issue":"8","first_page":"1158","last_page":"1163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13118","display_name":"Psychological Treatments and Disorders","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anger-attacks","display_name":"anger attacks","score":0.9959999918937683},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hostility","display_name":"hostility","score":0.8939999938011169},{"id":"https://openalex.org/keywords/irritability","display_name":"irritability","score":0.7689999938011169},{"id":"https://openalex.org/keywords/autonomic-arousal","display_name":"autonomic arousal","score":0.8360000252723694},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6039999723434448},{"id":"https://openalex.org/keywords/somatization","display_name":"somatization","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.9043436050415039},{"id":"https://openalex.org/C2779302386","wikidata":"https://www.wikidata.org/wiki/Q79871","display_name":"Anger","level":2,"score":0.8670237064361572},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.7090926766395569},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5954686403274536},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5629850029945374},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5028059482574463},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.3873385787010193},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37261244654655457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.276833713054657},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.09421396255493164},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000553","descriptor_name":"Ambulatory Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000786","descriptor_name":"Anger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006791","descriptor_name":"Hostility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010554","descriptor_name":"Personality Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010554","descriptor_name":"Personality Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010555","descriptor_name":"Personality Inventory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1176/ajp.150.8.1158","doi":"https://doi.org/10.1176/ajp.150.8.1158","is_oa":false,"landing_page_url":"https://doi.org/10.1176/ajp.150.8.1158","pdf_url":null,"source":{"id":"https://openalex.org/S116025658","display_name":"American Journal of Psychiatry","issn_l":"0002-953X","issn":["0002-953X","1535-7228"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316602","host_organization_name":"American Psychiatric Association","host_organization_lineage":["https://openalex.org/P4310316602"],"host_organization_lineage_names":["American Psychiatric Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:7848377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7848377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W92632756","https://openalex.org/W1921122118","https://openalex.org/W1979002939","https://openalex.org/W1982292219","https://openalex.org/W1998427892","https://openalex.org/W2003130956","https://openalex.org/W2050475423","https://openalex.org/W2066975631","https://openalex.org/W2084413241","https://openalex.org/W2114613490","https://openalex.org/W2138284714","https://openalex.org/W2242438439","https://openalex.org/W2327028940","https://openalex.org/W2327337999","https://openalex.org/W2410508614"],"related_works":["https://openalex.org/W83395442","https://openalex.org/W2085013700","https://openalex.org/W1766394166","https://openalex.org/W1972603928","https://openalex.org/W1816053984","https://openalex.org/W45063799","https://openalex.org/W58722471","https://openalex.org/W2073129689","https://openalex.org/W2094189009","https://openalex.org/W2081355159"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Anger":[1,62],"attacks":[2,46,54,176,203,228],"are":[3],"sudden,":[4],"intense":[5],"spells":[6],"of":[7,13,26,29,33,89,109,115,124,130,146,182,215,226,237],"anger":[8,45,136,175,202,227,241,252],"associated":[9],"with":[10,42,58,103,118,201],"a":[11,24,119,192,213,231],"surge":[12],"autonomic":[14],"arousal":[15],"including":[16],"such":[17,162],"symptoms":[18],"as":[19],"tachycardia,":[20],"sweating,":[21],"flushing,":[22],"and":[23,43,51,74,106,149,151,173,218,229,253],"feeling":[25],"being":[27],"out":[28],"control.":[30],"The":[31,61],"purpose":[32],"this":[34],"study":[35,211],"was":[36,191],"to":[37,56,99,107,247],"determine":[38],"whether":[39,52],"depressed":[40,132,220,238],"patients":[41,111,139,184,200,206,221,239],"without":[44,207,240],"exhibit":[47,161],"distinct":[48,234],"psychological":[49,232],"characteristics":[50],"these":[53,110,138,171,256],"respond":[55],"treatment":[57,117,245],"fluoxetine.":[59,125],"METHOD:":[60],"Attacks":[63],"Questionnaire,":[64,73],"the":[65,71,75,81,85,90,95,131,156,174,179,183,224],"Hamilton":[66],"Rating":[67],"Scale":[68,78],"for":[69,199,205],"Depression,":[70],"Symptom":[72],"Cook-Medley":[76],"Hostility":[77],"were":[79,167],"among":[80],"scales":[82],"administered":[83],"at":[84,94],"Depression":[86],"Research":[87],"Program":[88],"Clinical":[91],"Psychopharmacology":[92],"Unit":[93],"Massachusetts":[96],"General":[97],"Hospital":[98],"127":[100],"medication-free":[101],"outpatients":[102,133],"major":[104],"depression":[105],"85":[108],"after":[112],"8":[113],"weeks":[114],"open":[116],"fixed":[120],"dose":[121],"(20":[122],"mg/day)":[123],"RESULTS:":[126],"At":[127],"baseline,":[128],"44%":[129],"reported":[134,188],"having":[135],"attacks;":[137],"had":[140,186],"significantly":[141],"higher":[142],"scores":[143],"on":[144],"measures":[145],"anxiety,":[147],"somatization,":[148],"state":[150],"trait":[152],"hostility":[153,254],"than":[154,204],"did":[155,159],"subjects":[157],"who":[158,185,222],"not":[160],"attacks.":[163,242],"After":[164],"treatment,":[165],"there":[166],"significant":[168],"reductions":[169],"in":[170,178,250,255],"measures,":[172],"disappeared":[177],"majority":[180],"(71%)":[181],"previously":[187],"them.":[189,208],"There":[190],"trend":[193],"toward":[194],"greater":[195],"overall":[196],"clinical":[197],"improvement":[198],"CONCLUSIONS:":[209],"This":[210],"identified":[212],"subgroup":[214],"highly":[216],"irritable":[217],"hostile":[219],"report":[223],"presence":[225],"have":[230],"profile":[233],"from":[235],"that":[236],"Furthermore,":[243],"fluoxetine":[244],"appears":[246],"be":[248],"beneficial":[249],"reducing":[251],"patients.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
