{"id":"https://openalex.org/W6894029223","doi":"https://doi.org/10.5281/zenodo.7731017","title":"SEVI Inhibits A\u03b2 Amyloid Aggregation by Capping the \u03b2-Sheet Elongation Edges","display_name":"SEVI Inhibits A\u03b2 Amyloid Aggregation by Capping the \u03b2-Sheet Elongation Edges","publication_year":2023,"publication_date":"2023-03-14","ids":{"openalex":"https://openalex.org/W6894029223","doi":"https://doi.org/10.5281/zenodo.7731017"},"language":"en","primary_location":{"id":"pmh:oai:zenodo.org:7732322","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/7732322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/7732322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092042487","display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang, Ying","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xun, Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xun, Jia","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fengjuan Hang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengjuan Hang","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068186480","display_name":"Jiajia Yan","orcid":"https://orcid.org/0009-0005-3951-8987","observed_orcids":["https://orcid.org/0009-0005-3951-8987"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Yan","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023255450","display_name":"Xinjie Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinjie Fan","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zou, Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zou, Yu","raw_affiliation_strings":["Zhejiang Univerisity"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhejiang Univerisity","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wang, Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang, Chuang","raw_affiliation_strings":["Ningbo University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626869","display_name":"Feng Ding","orcid":"https://orcid.org/0000-0003-1850-6336","observed_orcids":["https://orcid.org/0000-0003-1850-6336"]},"institutions":[{"id":"https://openalex.org/I8078737","display_name":"Clemson University","ror":"https://ror.org/037s24f05","country_code":"US","type":"education","lineage":["https://openalex.org/I8078737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ding, Feng","raw_affiliation_strings":["Clemson University"],"raw_orcid":"https://orcid.org/0000-0003-1850-6336","affiliations":[{"raw_affiliation_string":"Clemson University","institution_ids":["https://openalex.org/I8078737"]}]},{"author_position":"last","author":{"id":null,"display_name":"Sun, Yunxiang","orcid":"https://orcid.org/0000-0001-9799-7131","observed_orcids":["https://orcid.org/0000-0001-9799-7131"]},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sun, Yunxiang","raw_affiliation_strings":["Ningbo University"],"raw_orcid":"https://orcid.org/0000-0001-9799-7131","affiliations":[{"raw_affiliation_string":"Ningbo University","institution_ids":["https://openalex.org/I109935558"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31069079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevi","display_name":"SEVI","score":0.9779999852180481},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.800000011920929},{"id":"https://openalex.org/keywords/amyloid-aggregation-inhibition","display_name":"amyloid aggregation inhibition","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.7940000295639038},{"id":"https://openalex.org/keywords/heteroaggregation","display_name":"heteroaggregation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7089999914169312},{"id":"https://openalex.org/keywords/fibril-nucleation","display_name":"fibril nucleation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7549999952316284},{"id":"https://openalex.org/C33947775","wikidata":"https://www.wikidata.org/wiki/Q271439","display_name":"Elongation","level":3,"score":0.6685000061988831},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.6462000012397766},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5774000287055969},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4796000123023987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45890000462532043},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4440000057220459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4309999942779541},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.3781999945640564},{"id":"https://openalex.org/C61048295","wikidata":"https://www.wikidata.org/wiki/Q909022","display_name":"Nucleation","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.2685000002384186},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.25609999895095825}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:zenodo.org:7732322","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/7732322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.7731017","doi":"https://doi.org/10.5281/zenodo.7731017","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.7731017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.7731018","doi":"https://doi.org/10.5281/zenodo.7731018","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.7731018","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.7732322","doi":"https://doi.org/10.5281/zenodo.7732322","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.7732322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:7732322","doi":null,"is_oa":true,"landing_page_url":"https://zenodo.org/record/7732322","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382703366","https://openalex.org/W2794865442","https://openalex.org/W3096142810","https://openalex.org/W6991434911","https://openalex.org/W3005315021","https://openalex.org/W3204727315","https://openalex.org/W4414032248","https://openalex.org/W4400782408","https://openalex.org/W7115602889","https://openalex.org/W2763359991"],"abstract_inverted_index":{"Inhibiting":[0],"the":[1,24,28,68,98,111,131,141,164,173,189],"aggregation":[2,79,120,137],"of":[3,27,36,59,71,143,176,180,191],"amyloid":[4],"peptides":[5,8],"with":[6,56,91],"endogenous":[7],"has":[9],"broad":[10],"interest":[11],"due":[12],"to":[13,89,117,145],"their":[14,157],"intrinsically":[15,54],"high":[16,64],"biocompatibility":[17],"and":[18,106,126,150],"low":[19],"immunogenicity.":[20],"Here,":[21],"we":[22],"investigated":[23],"inhibition":[25,179],"mechanism":[26,175],"prostatic":[29],"acidic":[30],"phosphatase":[31],"fragment":[32],"SEVI":[33,52,72,87,95,109,114,181],"(semen-derived":[34],"enhancer":[35],"viral":[37],"infection)":[38],"against":[39,182,194],"A\u03b242":[40,75,100,139,183],"fibrillization":[41],"using":[42],"atomistic":[43],"discrete":[44],"molecular":[45,174],"dynamics":[46],"simulations.":[47],"Our":[48],"result":[49],"revealed":[50],"that":[51],"was":[53,73],"disordered":[55],"dynamic":[57],"formation":[58,142],"residual":[60],"helices.":[61],"With":[62],"a":[63,77],"positive":[65],"net":[66],"charge,":[67],"self-aggregation":[69],"tendency":[70],"weak.":[74],"had":[76],"strong":[78],"propensity":[80],"by":[81,108,129,163],"readily":[82],"self-assembling":[83],"into":[84,148,188],"\u03b2-sheet-rich":[85],"aggregates.":[86],"preferred":[88],"interact":[90],"A\u03b242,":[92],"rather":[93],"than":[94],"themselves.":[96],"In":[97],"hetero-aggregates,":[99],"mainly":[101],"adopted":[102],"\u03b2-sheets":[103],"buried":[104],"inside":[105],"capped":[107],"in":[110],"outer":[112],"layer.":[113],"could":[115,153],"bind":[116],"various":[118],"A\u03b2":[119],"species":[121],"\u2013":[122,128],"including":[123],"monomers,":[124],"dimers,":[125],"proto-fibrils":[127],"capping":[130],"exposed":[132],"\u03b2-sheet":[133,158],"elongation":[134,159],"edges.":[135],"The":[136],"processes":[138],"from":[140],"oligomers":[144],"conformational":[146],"nucleation":[147],"fibrils":[149],"fibril":[151],"growth":[152],"be":[154],"inhibited":[155],"as":[156],"edges":[160],"being":[161],"occupied":[162],"highly":[165],"charged":[166],"SEVI.":[167],"Overall,":[168],"our":[169],"computational":[170],"study":[171],"uncovered":[172],"experimentally":[177],"observed":[178],"aggregation,":[184],"providing":[185],"novel":[186],"insights":[187],"development":[190],"therapeutic":[192],"strategies":[193],"Alzheimer's":[195],"disease.":[196]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
