{"id":"https://openalex.org/W68885281","doi":null,"title":"Acute ultrastructural changes of cornea after excimer laser ablation.","display_name":"Acute ultrastructural changes of cornea after excimer laser ablation.","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W68885281","mag":"68885281","pmid":"https://pubmed.ncbi.nlm.nih.gov/1544782"},"language":"en","primary_location":{"id":"pmid:1544782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1544782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011615193","display_name":"S A Ozler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S A Ozler","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic, Irvine, CA 92715"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic, Irvine, CA 92715","institution_ids":["https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709883","display_name":"L.\u2010H. Liaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L H Liaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025587149","display_name":"Joseph Neev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Neev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015834763","display_name":"Daniel Raney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Raney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084427519","display_name":"Michael W. Berns","orcid":"https://orcid.org/0000-0002-9640-2885","observed_orcids":["https://orcid.org/0000-0002-9640-2885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M W Berns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4289,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.62617885,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"33","issue":"3","first_page":"540","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10732","display_name":"Laser Material Processing Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excimer-laser-ablation","display_name":"excimer laser ablation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/corneal-ultrastructure","display_name":"corneal ultrastructure","score":0.9200000166893005},{"id":"https://openalex.org/keywords/arf-excimer-laser","display_name":"ArF excimer laser","score":0.9710000157356262},{"id":"https://openalex.org/keywords/laser-repetition-rate","display_name":"laser repetition rate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/corneal-endothelium-damage","display_name":"corneal endothelium damage","score":0.8460000157356262},{"id":"https://openalex.org/keywords/descemet-s-membrane","display_name":"Descemet's membrane","score":0.9319999814033508},{"id":"https://openalex.org/keywords/laser-refractive-surgery","display_name":"laser refractive surgery","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780477314","wikidata":"https://www.wikidata.org/wiki/Q241056","display_name":"Excimer laser","level":3,"score":0.8373401165008545},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.8093945980072021},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7781277894973755},{"id":"https://openalex.org/C74561354","wikidata":"https://www.wikidata.org/wiki/Q901723","display_name":"Excimer","level":3,"score":0.7248105406761169},{"id":"https://openalex.org/C2778305132","wikidata":"https://www.wikidata.org/wiki/Q1806547","display_name":"Photoablation","level":4,"score":0.5348882079124451},{"id":"https://openalex.org/C2775901793","wikidata":"https://www.wikidata.org/wiki/Q1189806","display_name":"Corneal endothelium","level":3,"score":0.5203402042388916},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.4930102527141571},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.45344075560569763},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.41521722078323364},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3295729160308838},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2645544707775116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053685","descriptor_name":"Laser Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1544782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1544782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:68885281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1544782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4607486877","display_name":"A Laser Microbeam Biotechnology Resource","funder_award_id":"P41RR001192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135637392","https://openalex.org/W1991072921","https://openalex.org/W2034266979","https://openalex.org/W1522989496","https://openalex.org/W7099352977","https://openalex.org/W50278602","https://openalex.org/W2039641739","https://openalex.org/W1984292749","https://openalex.org/W2158097511","https://openalex.org/W2026871615"],"abstract_inverted_index":{"Corneal":[0],"ultrastructural":[1],"changes":[2,84],"induced":[3],"by":[4],"an":[5,67,78],"argon":[6],"fluoride":[7],"excimer":[8,145],"laser":[9,146],"using":[10,131],"different":[11,38],"parameters":[12],"were":[13,18,85],"investigated.":[14],"Twenty-eight":[15],"rabbit":[16],"corneas":[17],"ablated":[19],"at":[20,36,52,120],"light":[21,40,54,93],"doses":[22,41,55,94],"per":[23,56,95],"pulse":[24,57],"and":[25,32,65,77,101,117],"repetition":[26,59,99,105,132,141],"rates":[27,60,106,133,142],"ranging":[28],"from":[29],"25-800":[30],"mJ/cm2":[31],"1-100":[33],"Hz,":[34],"respectively,":[35],"four":[37],"total":[39],"(25-150":[42],"J/cm2).":[43],"Transmission":[44],"electron":[45],"microscopy":[46],"showed":[47],"that":[48,125,139],"corneal":[49,147],"ablations":[50,89],"done":[51,90],"subthreshold":[53],"with":[58,66],"higher":[61],"than":[62,70],"30":[63],"Hz":[64,111],"exposure":[68,102],"more":[69],"100":[71],"sec":[72],"caused":[73,112],"significant":[74],"surface":[75],"coagulation":[76],"increase":[79],"in":[80,88],"pseudomembrane":[81],"thickness.":[82],"These":[83],"not":[86,127],"observed":[87],"above":[91],"threshold":[92],"pulse,":[96],"regardless":[97],"of":[98],"rate":[100],"time.":[103],"However,":[104],"as":[107,109],"high":[108,140],"80":[110],"damage":[113,130,152],"to":[114,153],"the":[115,121,154],"endothelium":[116],"Descemet's":[118],"membrane":[119],"same":[122],"ablation":[123],"depth":[124],"did":[126],"cause":[128,150],"such":[129],"under":[134],"40":[135],"Hz.":[136],"It":[137],"appears":[138],"used":[143],"during":[144],"surgery":[148],"may":[149],"irreversible":[151],"cornea.":[155]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}