{"id":"https://openalex.org/W68882270","doi":null,"title":"Antiproteinuric effect of renin-angiotensin-aldosterone system (RAAS) blockade in obese patients: Which is the most efficient option?","display_name":"Antiproteinuric effect of renin-angiotensin-aldosterone system (RAAS) blockade in obese patients: Which is the most efficient option?","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W68882270","mag":"68882270"},"language":"en","primary_location":{"id":"pmh:oai:hispana.mcu.es:5990000","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952009000500007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036894659","display_name":"Enrique Morales","orcid":"https://orcid.org/0000-0002-5824-6973","observed_orcids":["https://orcid.org/0000-0002-5824-6973"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Enrique Morales","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0002-5824-6973","affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010010165","display_name":"Ana Huerta","orcid":"https://orcid.org/0000-0003-3342-7628","observed_orcids":["https://orcid.org/0000-0003-3342-7628"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Huerta","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0003-3342-7628","affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112142845","display_name":"Eduardo Guti\u00e9rrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo Guti\u00e9rrez","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110323481","display_name":"E. Guti\u00e9rrez Sol\u00eds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"E. Guti\u00e9rrez Sol\u00eds","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036491867","display_name":"J. Segura","orcid":"https://orcid.org/0000-0003-4677-9526","observed_orcids":["https://orcid.org/0000-0003-4677-9526"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"J. Segura","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0003-4677-9526","affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052017202","display_name":"Manuel Praga","orcid":"https://orcid.org/0000-0001-9270-1071","observed_orcids":["https://orcid.org/0000-0001-9270-1071"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Praga","raw_affiliation_strings":["Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a"],"raw_orcid":"https://orcid.org/0000-0001-9270-1071","affiliations":[{"raw_affiliation_string":"Hospital Universitario 12 de Octubre, Madrid, Espa\u00f1a","institution_ids":["https://openalex.org/I4210101691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210101691"],"apc_list":null,"apc_paid":null,"fwci":0.4234,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67898638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"29","issue":"5","first_page":"421","last_page":"429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.4867999851703644,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.3384000062942505,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6079999804496765},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.9950000047683716},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system-blockade","display_name":"renin-angiotensin-aldosterone system blockade","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lisinopril","display_name":"lisinopril","score":0.9750000238418579},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9620000123977661},{"id":"https://openalex.org/keywords/candesartan","display_name":"candesartan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor-antagonists","display_name":"mineralocorticoid receptor antagonists","score":0.8870000243186951},{"id":"https://openalex.org/keywords/eplerenone","display_name":"eplerenone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antiproteinuric-therapy","display_name":"antiproteinuric therapy","score":0.7710000276565552},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.47099998593330383},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.7348051071166992},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6763138771057129},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.676145613193512},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5787965059280396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47440075874328613},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35688453912734985},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12629669904708862},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07381424307823181}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:hispana.mcu.es:5990000","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952009000500007","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:scielo:S0211-69952009000500007","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0211-69952009000500007","pdf_url":null,"source":{"id":"https://openalex.org/S4306402135","display_name":"Scientific Electronic library online (Sciences Carlos III Health Institute)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801357902","host_organization_name":"Instituto de Salud Carlos III","host_organization_lineage":["https://openalex.org/I2801357902"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nefrolog\u00c3\u00ada (Madrid) v.29 n.5 2009","raw_type":"journal article"},{"id":"mag:1849418964","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/pdf/nefrologia/v29n5/07_original4.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S172832105","display_name":"Nefrolog\u00eda","issn_l":"0211-6995","issn":["0211-6995","1989-2284","2014-3273"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nefrolog\u00eda","raw_type":null},{"id":"mag:68882270","doi":null,"is_oa":false,"landing_page_url":"http://scielo.isciii.es/pdf/nefrologia/v29n5/07_original4.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S172832105","display_name":"Nefrolog\u00eda","issn_l":"0211-6995","issn":["0211-6995","1989-2284","2014-3273"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Nefrolog\u00eda","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W2000812251","https://openalex.org/W2003508199","https://openalex.org/W2003670762","https://openalex.org/W2007157760","https://openalex.org/W2017268330","https://openalex.org/W2019270553","https://openalex.org/W2022266546","https://openalex.org/W2031204813","https://openalex.org/W2039893332","https://openalex.org/W2039985181","https://openalex.org/W2044773944","https://openalex.org/W2048475555","https://openalex.org/W2049683553","https://openalex.org/W2056976690","https://openalex.org/W2066446806","https://openalex.org/W2074391878","https://openalex.org/W2080760372","https://openalex.org/W2090621492","https://openalex.org/W2091781256","https://openalex.org/W2097090923","https://openalex.org/W2098100684","https://openalex.org/W2100409734","https://openalex.org/W2100923541","https://openalex.org/W2107319610","https://openalex.org/W2110446902","https://openalex.org/W2114339665","https://openalex.org/W2118932957","https://openalex.org/W2128996416","https://openalex.org/W2132715232","https://openalex.org/W2147273166","https://openalex.org/W2148303421","https://openalex.org/W2150856330","https://openalex.org/W2152094259","https://openalex.org/W2170453602","https://openalex.org/W2312400976","https://openalex.org/W2327112682","https://openalex.org/W2615684303"],"related_works":["https://openalex.org/W2406205270","https://openalex.org/W1849418964","https://openalex.org/W2404793470","https://openalex.org/W2469460709","https://openalex.org/W1821239563","https://openalex.org/W7073991467","https://openalex.org/W2322842583","https://openalex.org/W2944234815","https://openalex.org/W2400365467","https://openalex.org/W2171452744"],"abstract_inverted_index":{"Introducci\u00f3n:":[0],"La":[1,205,292],"obesidad":[2],"aumenta":[3],"el":[4,169,185],"riesgo":[5],"de":[6,16,26,34,37,45,53,57,62,65,70,97,107,110,152,154,161,174,179,182,187,193,207,257,264,273,296,303,327],"proteinuria":[7,103,173,195,209,275,320],"e":[8],"insuficiencia":[9],"renal":[10],"cr\u00f3nica,":[11],"y":[12,33,84,120,144,184,231,236,253,282,300],"acelera":[13],"la":[14,27,43,54,58,66,71,172,194,208,227,274,297,301,319],"progresi\u00f3n":[15],"enfermedades":[17],"renales.":[18],"En":[19],"los":[20,35,63,158,313],"pacientes":[21,74,94,113,188,265,322],"obesos":[22,75,95,323],"existe":[23],"un":[24,81,88,125,150],"aumento":[25],"actividad":[28],"del":[29,166],"sistema":[30],"renina-angiotensina-aldosterona":[31],"(SRAA)":[32],"niveles":[36],"aldosterona.":[38],"Ning\u00fan":[39],"estudio":[40,82,167],"ha":[41],"comparado":[42],"eficacia":[44],"las":[46],"diferentes":[47,159,325],"estrategias":[48],"antiprotein\u00faricas":[49],"actualmente":[50],"disponibles":[51],"(inhibidores":[52],"enzima":[55],"convertidora":[56],"angiotensina":[59,67],"[IECA],":[60],"antagonistas":[61,69,295],"receptores":[64],"[ARA],":[68],"aldosterona)":[72],"en":[73,87,121,171,315,321],"con":[76,102,124,133,199,220,229,279,288,294,305,324],"nefropat\u00edas":[77,328],"protein\u00faricas.":[78,330],"M\u00e9todos:":[79],"Es":[80],"prospectivo":[83],"aleatorizado,":[85],"realizado":[86],"\u00fanico":[89],"centro.":[90],"Fueron":[91],"seleccionados":[92],"doce":[93],"(\u00edndice":[96],"masa":[98],"corporal":[99],">30":[100],"kg/m\u00b2),":[101],">0,5":[104],"g/24":[105],"h,":[106],"nuestras":[108],"consultas":[109],"Nefrolog\u00eda.":[111],"Los":[112],"fueron":[114,309],"tratados":[115],"consecutivamente":[116],"durante":[117],"seis":[118,155],"semanas":[119,156],"orden":[122],"aleatorio":[123],"IECA":[126,134,306,314],"(lisinopril":[127,137],"20":[128],"mg/d\u00eda),":[129],"una":[130,191,242,268],"terapia":[131,302],"combinada":[132],"m\u00e1s":[135,140,310],"ARA":[136,308],"10":[138],"mg/d\u00eda":[139],"candesart\u00e1n":[141,232,285],"16":[142],"mg/d\u00eda)":[143],"eplerenona":[145,237,280],"(25":[146],"mg/d\u00eda).":[147],"Se":[148],"estableci\u00f3":[149],"per\u00edodo":[151,181],"lavado":[153],"entre":[157,260],"per\u00edodos":[160],"tratamiento.":[162],"El":[163,262],"objetivo":[164],"principal":[165],"fue":[168,217,276],"cambio":[170],"24":[175],"h":[176],"al":[177,197,201,222,255,271],"final":[178],"cada":[180],"tratamiento":[183],"n\u00famero":[186,263],"que":[189,226,266,287,312],"mostraban":[190],"reducci\u00f3n":[192,206,228,269],"superior":[196],"25%":[198,272],"respecto":[200,221],"valor":[202,223],"basal.":[203],"Resultados:":[204],"obtenida":[210],"por":[211],"lisinopril":[212,230,258,283,289],"(11,3":[213],"\u00b1":[214,234,239],"34,8%)":[215],"no":[216],"estad\u00edsticamente":[218,244],"significativa":[219,245],"basal,":[224],"mientras":[225],"(26,9":[233],"30,6%)":[235],"(28,4":[238],"31,6%)":[240],"mostr\u00f3":[241],"diferencia":[243],"frente":[246,254],"a":[247],"sus":[248],"valores":[249],"basales":[250],"(comparaci\u00f3n":[251,259],"intragrupo)":[252],"grupo":[256],"grupos).":[261],"mostraron":[267],"mayor":[270,278],"significativamente":[277],"(67%)":[281,286],"+":[284,307],"(25%).":[290],"Conclusiones:":[291],"monoterapia":[293,316],"aldosterona":[298],"(eplerenona)":[299],"combinaci\u00f3n":[304],"efectivos":[311],"para":[317],"reducir":[318],"tipos":[326],"cr\u00f3nicas":[329]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}