{"id":"https://openalex.org/W68834936","doi":null,"title":"Excess of factor X antigen versus clotting counterpart in coumarin treated patients as determined by an Elisa method.","display_name":"Excess of factor X antigen versus clotting counterpart in coumarin treated patients as determined by an Elisa method.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W68834936","mag":"68834936","pmid":"https://pubmed.ncbi.nlm.nih.gov/2410342"},"language":"en","primary_location":{"id":"pmid:2410342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2410342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia haematologica (Leipzig, Germany : 1928)","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046561459","display_name":"Antonio Girolami","orcid":"https://orcid.org/0000-0002-8314-2009","observed_orcids":["https://orcid.org/0000-0002-8314-2009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Girolami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110186582","display_name":"Maria Angela Vicarioto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Vicarioto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024337803","display_name":"G. Ruzza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Ruzza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059629523","display_name":"A Vergolani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Vergolani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073626306","display_name":"Giuseppe Boeri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Boeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5049,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62062389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"2","first_page":"326","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/factor-x-activity","display_name":"factor X activity","score":0.8949999809265137},{"id":"https://openalex.org/keywords/long-term-anticoagulation","display_name":"long-term anticoagulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.7490000128746033},{"id":"https://openalex.org/keywords/electroimmunoassay","display_name":"electroimmunoassay","score":0.8109999895095825},{"id":"https://openalex.org/keywords/laser-nephelometry","display_name":"laser nephelometry","score":0.8629999756813049},{"id":"https://openalex.org/keywords/assay-comparison","display_name":"assay comparison","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6928752064704895},{"id":"https://openalex.org/C2777444498","wikidata":"https://www.wikidata.org/wiki/Q423701","display_name":"Factor X","level":4,"score":0.6554975509643555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48658668994903564},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.46686482429504395},{"id":"https://openalex.org/C2781338262","wikidata":"https://www.wikidata.org/wiki/Q111812","display_name":"Coumarin","level":2,"score":0.4548838436603546},{"id":"https://openalex.org/C2992139802","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Clotting factor","level":2,"score":0.4313867390155792},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.42121559381484985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3846597671508789},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32560139894485474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29877662658691406},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.19469162821769714},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.14538991451263428},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005170","descriptor_name":"Factor X","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005170","descriptor_name":"Factor X","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2410342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2410342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia haematologica (Leipzig, Germany : 1928)","raw_type":"Journal Article"},{"id":"mag:68834936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2410342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1861491057","https://openalex.org/W9201593","https://openalex.org/W7099382455","https://openalex.org/W1968006825","https://openalex.org/W2320249094","https://openalex.org/W2141836865","https://openalex.org/W2087736935","https://openalex.org/W4239535479","https://openalex.org/W2436129897","https://openalex.org/W2411243577"],"abstract_inverted_index":{"Factor":[0],"X":[1,54,58,75,86],"antigen":[2,32,55,87],"was":[3,23,34,50],"assayed":[4],"by":[5],"means":[6],"of":[7],"an":[8],"Elisa":[9,76],"(sandwich)":[10],"method":[11,61,77,83],"in":[12],"36":[13],"patients":[14],"on":[15],"long-term":[16],"anticoagulant":[17],"therapy.":[18],"The":[19,60],"average":[20],"value":[21],"observed":[22],"31.4%":[24],"+/-":[25,41],"12.2.":[26],"In":[27,43],"almost":[28],"every":[29],"instance":[30],"the":[31,37],"level":[33],"higher":[35],"than":[36],"clotting":[38],"counterpart":[39],"(14.4%":[40],"4.5).":[42],"a":[44,81],"few":[45],"instances":[46],"no":[47],"major":[48],"difference":[49],"noted":[51],"between":[52],"factor":[53,57,74,85],"and":[56,70],"activity.":[59],"correlated":[62],"fairly":[63],"well":[64],"with":[65],"other":[66],"immunological":[67],"methods":[68],"(electroimmunoassay":[69],"Laser":[71],"Nephelometer).":[72],"Therefore,":[73],"appears":[78],"to":[79],"be":[80],"suitable":[82],"for":[84],"evaluation.":[88]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}