{"id":"https://openalex.org/W68817271","doi":null,"title":"Brain enkephalin receptors in Parkinson's disease.","display_name":"Brain enkephalin receptors in Parkinson's disease.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W68817271","mag":"68817271","pmid":"https://pubmed.ncbi.nlm.nih.gov/6321647"},"language":"en","primary_location":{"id":"pmid:6321647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6321647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111593194","display_name":"U. K. Rinne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U K Rinne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108404526","display_name":"J. K. Rinne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Rinne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087888043","display_name":"Juha O. Rinne","orcid":"https://orcid.org/0000-0001-6369-0764","observed_orcids":["https://orcid.org/0000-0001-6369-0764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J O Rinne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046608248","display_name":"KAREN LAAKSO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Laakso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072685466","display_name":"Olli S. Tenovuo","orcid":"https://orcid.org/0000-0003-1876-3180","observed_orcids":["https://orcid.org/0000-0003-1876-3180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Tenovuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017080297","display_name":"Pirkko L\u00f6nnberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L\u00f6nnberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"V Koskinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Koskinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.00620719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":null,"first_page":"163","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7904999852180481,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.19449999928474426,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8410000205039978},{"id":"https://openalex.org/keywords/enkephalin-receptors","display_name":"enkephalin receptors","score":0.9539999961853027},{"id":"https://openalex.org/keywords/leu-enkephalin","display_name":"leu-enkephalin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/naloxone-binding","display_name":"naloxone binding","score":0.9570000171661377},{"id":"https://openalex.org/keywords/receptor-supersensitivity","display_name":"receptor supersensitivity","score":0.7179999947547913},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8690000176429749},{"id":"https://openalex.org/keywords/caudate-nucleus","display_name":"caudate nucleus","score":0.9520000219345093},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.902999997138977},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9829999804496765},{"id":"https://openalex.org/keywords/limbic-cortex","display_name":"limbic cortex","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.8289999961853027},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2777803847","wikidata":"https://www.wikidata.org/wiki/Q325101","display_name":"Enkephalin","level":4,"score":0.7262985706329346},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.7027053833007812},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.681986391544342},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.6608569025993347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6518595218658447},{"id":"https://openalex.org/C2781423529","wikidata":"https://www.wikidata.org/wiki/Q1132309","display_name":"Caudate nucleus","level":2,"score":0.6367224454879761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6144140958786011},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46993881464004517},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44864752888679504},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44847556948661804},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.41156303882598877},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4006795287132263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31267204880714417},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2332477569580078},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.21473580598831177},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.1827816665172577},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.06324988603591919},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004743","descriptor_name":"Enkephalin, Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004744","descriptor_name":"Enkephalin, Methionine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6321647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6321647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural transmission. Supplementum","raw_type":"Journal Article"},{"id":"mag:68817271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6321647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2419176067","https://openalex.org/W2056327020","https://openalex.org/W2419313627","https://openalex.org/W2082857206","https://openalex.org/W1998086668","https://openalex.org/W18319520","https://openalex.org/W2063790734","https://openalex.org/W2036532498","https://openalex.org/W2000638034","https://openalex.org/W2005456488"],"abstract_inverted_index":{"Brain":[0],"enkephalin":[1,85,109,135],"receptors":[2,110,125],"were":[3],"studied":[4],"in":[5,43,62,70,95,111,126,137],"post-mortem":[6],"brain":[7,134],"samples":[8],"of":[9,16,35,91,105,108,122,132,141],"27":[10],"patients":[11],"with":[12],"Parkinson's":[13,142],"disease":[14],"and":[15,30,38,52,114],"26":[17],"control":[18],"subjects":[19],"without":[20],"extrapyramidal":[21],"disorders":[22],"by":[23],"the":[24,44,63,71,84,96,112,127,130,138],"radioligand-binding":[25],"technique":[26],"using":[27],"3H-leu-enkephalin,":[28],"3H-met-enkephalin":[29],"3H-naloxone.":[31],"The":[32],"specific":[33],"binding":[34,90],"both":[36],"3H-leu-":[37],"3H-met-enkephalins":[39],"was":[40,59,93],"significantly":[41,88],"increased":[42],"caudate":[45,98],"nucleus,":[46],"putamen,":[47],"nucleus":[48],"accumbens,":[49],"limbic":[50,115],"cortex":[51],"hippocampus.":[53],"Scatchard":[54],"analysis":[55],"showed":[56],"that":[57],"there":[58,101],"an":[60],"increase":[61],"receptor":[64],"number,":[65],"but":[66],"no":[67],"significant":[68,81],"changes":[69],"mean":[72],"dissociation":[73],"constant.":[74],"Levodopa":[75],"treatment":[76],"did":[77],"not":[78],"have":[79],"any":[80],"effect":[82],"on":[83],"bindings.":[86],"A":[87],"decreased":[89],"3H-naloxone":[92],"found":[94],"parkinsonian":[97],"nucleus.":[99],"Thus":[100],"is":[102],"a":[103,106,120],"supersensitivity":[104],"population":[107],"striatum":[113],"system,":[116],"as":[117,119],"well":[118],"loss":[121],"other":[123],"opiate":[124],"striatum,":[128],"suggesting":[129],"involvement":[131],"certain":[133],"neurons":[136],"pathophysiological":[139],"process":[140],"disease.":[143]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
