{"id":"https://openalex.org/W68794505","doi":null,"title":"The role of T cells in osteoporosis, an update.","display_name":"The role of T cells in osteoporosis, an update.","publication_year":2009,"publication_date":"2009-05-20","ids":{"openalex":"https://openalex.org/W68794505","mag":"68794505","pmid":"https://pubmed.ncbi.nlm.nih.gov/19636401","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713452"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1492605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713452","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713452","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034979649","display_name":"Wen Zhao","orcid":"https://orcid.org/0000-0003-4566-5914","observed_orcids":["https://orcid.org/0000-0003-4566-5914"]},"institutions":[{"id":"https://openalex.org/I4210126345","display_name":"Beijing Aerospace General Hospital","ror":"https://ror.org/02zxyre23","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210126345"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhao","raw_affiliation_strings":["Department of Orthopedics, Beijing Aerospace General Hospital Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Beijing Aerospace General Hospital Beijing, China","institution_ids":["https://openalex.org/I4210126345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685992","display_name":"Yuying Liu","orcid":"https://orcid.org/0000-0003-3848-9254","observed_orcids":["https://orcid.org/0000-0003-3848-9254","https://orcid.org/0000-0003-0415-1124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuying Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine M Cahill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine M Cahill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113452862","display_name":"Wenlu Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenlu Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071704528","display_name":"Jack T. Rogers","orcid":"https://orcid.org/0000-0003-1262-8578","observed_orcids":["https://orcid.org/0000-0003-1262-8578"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack T Rogers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112674630","display_name":"Xudong Huang","orcid":"https://orcid.org/0009-0008-8573-1596","observed_orcids":["https://orcid.org/0009-0008-8573-1596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xudong Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5494,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.58981446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2","issue":"6","first_page":"544","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/bone-immune-interaction","display_name":"bone-immune interaction","score":0.6010000109672546},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.8569999933242798},{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.8730000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.7288239002227783},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7011524438858032},{"id":"https://openalex.org/C26374806","wikidata":"https://www.wikidata.org/wiki/Q7107616","display_name":"Osteoimmunology","level":5,"score":0.6677976846694946},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.6676616668701172},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6042757630348206},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.503311812877655},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.46125850081443787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4375171959400177},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3508126735687256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34550154209136963},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33858737349510193},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22503983974456787},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.21574079990386963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15746325254440308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13710910081863403},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:1492605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713452","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:19636401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19636401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2713452","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2713452/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"pmh:oai:dash.harvard.edu:1/37372447","doi":null,"is_oa":false,"landing_page_url":"https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372447","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"mag:68794505","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19636401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1492605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2713452","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1511403203","https://openalex.org/W1523595999","https://openalex.org/W1536853938","https://openalex.org/W1555919277","https://openalex.org/W1677043489","https://openalex.org/W1964650077","https://openalex.org/W1967502057","https://openalex.org/W1968796843","https://openalex.org/W1969323709","https://openalex.org/W1977753585","https://openalex.org/W1979036381","https://openalex.org/W1979354204","https://openalex.org/W1981803131","https://openalex.org/W1997585969","https://openalex.org/W1997722036","https://openalex.org/W1999752605","https://openalex.org/W2009640996","https://openalex.org/W2012419453","https://openalex.org/W2014830732","https://openalex.org/W2015178646","https://openalex.org/W2016020334","https://openalex.org/W2021008851","https://openalex.org/W2021154537","https://openalex.org/W2022509414","https://openalex.org/W2022652983","https://openalex.org/W2022749534","https://openalex.org/W2023677969","https://openalex.org/W2024932182","https://openalex.org/W2030811514","https://openalex.org/W2033394124","https://openalex.org/W2034014808","https://openalex.org/W2038026702","https://openalex.org/W2042546270","https://openalex.org/W2044482752","https://openalex.org/W2052084644","https://openalex.org/W2060943696","https://openalex.org/W2061543337","https://openalex.org/W2064741899","https://openalex.org/W2071940607","https://openalex.org/W2078656162","https://openalex.org/W2084847794","https://openalex.org/W2085419497","https://openalex.org/W2089591066","https://openalex.org/W2092099741","https://openalex.org/W2092505499","https://openalex.org/W2092602103","https://openalex.org/W2094885043","https://openalex.org/W2096234941","https://openalex.org/W2098645445","https://openalex.org/W2099989406","https://openalex.org/W2105871881","https://openalex.org/W2114293211","https://openalex.org/W2114982159","https://openalex.org/W2115075530","https://openalex.org/W2130443006","https://openalex.org/W2133281510","https://openalex.org/W2136357996","https://openalex.org/W2137230091","https://openalex.org/W2137512902","https://openalex.org/W2140709802","https://openalex.org/W2150740381","https://openalex.org/W2151440511","https://openalex.org/W2153983398","https://openalex.org/W2155575117","https://openalex.org/W2168961998","https://openalex.org/W4301914653"],"related_works":["https://openalex.org/W2812112","https://openalex.org/W1963657210","https://openalex.org/W3048084685","https://openalex.org/W1520951628","https://openalex.org/W2048460721","https://openalex.org/W2078047860","https://openalex.org/W2181934487","https://openalex.org/W1545626147","https://openalex.org/W2114293211","https://openalex.org/W2795727128"],"abstract_inverted_index":{"Emerging":[0],"evidence":[1,15],"highlights":[2],"the":[3,6,9,66,80,97],"importance":[4],"of":[5,53,65,68,79,96],"interplay":[7],"between":[8,99],"bone":[10,34,102],"and":[11,25,32,46,58,71,76,84,101],"immune":[12,100],"systems.":[13,117],"That":[14],"bolsters":[16],"a":[17],"longstanding":[18],"recognition":[19],"that":[20,43,112],"estrogen":[21],"deficiency,":[22],"infection,":[23],"inflammation,":[24],"autoimmune":[26],"disorders":[27],"are":[28],"associated":[29],"with":[30],"systemic":[31],"local":[33],"loss.":[35],"Yet,":[36],"only":[37],"recently":[38],"has":[39],"an":[40],"understanding":[41,64],"emerged":[42],"T":[44,69],"lymphocytes":[45,70],"their":[47,72,88],"products":[48,73],"act":[49],"as":[50],"key":[51],"regulators":[52],"osteoclast":[54],"formation,":[55],"life":[56],"span,":[57],"activity.":[59],"This":[60],"review":[61],"presents":[62],"this":[63],"process":[67],"mediating":[74],"osteoporosis":[75],"explores":[77],"some":[78],"most":[81],"recent":[82],"findings":[83],"hypotheses":[85],"to":[86,106],"explain":[87],"action":[89],"in":[90],"bone.":[91],"A":[92],"more":[93],"complete":[94],"appreciation":[95],"interactions":[98],"cells":[103],"should":[104],"lead":[105],"targeted":[107],"therapeutic":[108],"strategies":[109],"for":[110],"diseases":[111],"affect":[113],"either":[114],"or":[115],"both":[116]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}