{"id":"https://openalex.org/W6878446","doi":null,"title":"Ticlopidine treatment for patients with unstable angina at rest. A further analysis of the study of ticlopidine in unstable angina. Studio della Ticlopidina nell'Angina Instabile Group.","display_name":"Ticlopidine treatment for patients with unstable angina at rest. A further analysis of the study of ticlopidine in unstable angina. Studio della Ticlopidina nell'Angina Instabile Group.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W6878446","mag":"6878446","pmid":"https://pubmed.ncbi.nlm.nih.gov/1806376"},"language":"en","primary_location":{"id":"pmid:1806376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1806376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082849561","display_name":"Domenico Scrutinio","orcid":"https://orcid.org/0000-0002-8535-3264","observed_orcids":["https://orcid.org/0000-0002-8535-3264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Scrutinio","raw_affiliation_strings":["Clinica del Lavoro Foundation, Institute of Care and Research, Bari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica del Lavoro Foundation, Institute of Care and Research, Bari, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064703521","display_name":"Rocco Lagioia","orcid":"https://orcid.org/0000-0002-2036-1634","observed_orcids":["https://orcid.org/0000-0002-2036-1634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Lagioia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085918109","display_name":"Paolo Rizzon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Rizzon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7071,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68551264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"12 Suppl G","issue":null,"first_page":"27","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticlopidine","display_name":"ticlopidine","score":1.0},{"id":"https://openalex.org/keywords/unstable-angina","display_name":"unstable angina","score":0.9020000100135803},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.859000027179718},{"id":"https://openalex.org/keywords/vascular-mortality","display_name":"vascular death","score":0.9639999866485596},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.828000009059906},{"id":"https://openalex.org/keywords/nitrate","display_name":"nitrate","score":0.9879999756813049},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7649999856948853},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9503147602081299},{"id":"https://openalex.org/C2778905298","wikidata":"https://www.wikidata.org/wiki/Q420571","display_name":"Ticlopidine","level":4,"score":0.8783013820648193},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.710865318775177},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5948020219802856},{"id":"https://openalex.org/C2777785093","wikidata":"https://www.wikidata.org/wiki/Q2032041","display_name":"Unstable angina","level":3,"score":0.563477635383606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5457637906074524},{"id":"https://openalex.org/C2778425758","wikidata":"https://www.wikidata.org/wiki/Q180762","display_name":"Angina","level":3,"score":0.5261352062225342},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48893800377845764},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4883720278739929},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38718244433403015},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32395443320274353},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.10868248343467712}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000789","descriptor_name":"Angina, Unstable","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000789","descriptor_name":"Angina, Unstable","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000789","descriptor_name":"Angina, Unstable","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000789","descriptor_name":"Angina, Unstable","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:1806376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1806376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Clinical Trial"},{"id":"mag:2491708020","doi":null,"is_oa":false,"landing_page_url":"https://moh-it.pure.elsevier.com/en/publications/ticlopidine-treatment-for-patients-with-unstable-angina-at-rest-a","pdf_url":null,"source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"European Heart Journal","raw_type":null},{"id":"mag:6878446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1806376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1994777661","https://openalex.org/W2064647083","https://openalex.org/W1987846050","https://openalex.org/W4245504819","https://openalex.org/W2047330128","https://openalex.org/W2068540732","https://openalex.org/W1983885389","https://openalex.org/W2105311655","https://openalex.org/W2045194959","https://openalex.org/W2051533305","https://openalex.org/W2163660095","https://openalex.org/W1973234645","https://openalex.org/W2190330961","https://openalex.org/W2027088467","https://openalex.org/W2092873988","https://openalex.org/W170502564","https://openalex.org/W2054954756","https://openalex.org/W2025302524"],"related_works":["https://openalex.org/W1990963444","https://openalex.org/W2491708020","https://openalex.org/W1965645590","https://openalex.org/W2778141781","https://openalex.org/W2074524543","https://openalex.org/W3149171268","https://openalex.org/W2182984440","https://openalex.org/W2424601053","https://openalex.org/W4246477363","https://openalex.org/W2889104880"],"abstract_inverted_index":{"Data":[0],"collected":[1],"to":[2,72,98,119,135],"investigate":[3],"the":[4,28,73,90,150,157,172,179,200,207,220,243,248],"effects":[5],"of":[6,11,67,85,110,130,183,203],"ticlopidine":[7,48,158,180,204],"in":[8,89,149,156,171,178,206],"a":[9,226],"subset":[10],"489":[12,29],"patients":[13,146,170,208,235],"with":[14,209,241],"angina":[15,210],"at":[16,211],"rest":[17,212],"accompanied":[18,213],"by":[19,214],"transient":[20,215],"ischaemic":[21,216],"electrocardiographic":[22,217],"changes":[23,218],"have":[24],"been":[25],"analysed.":[26],"Of":[27],"patients,":[30],"255":[31],"received":[32,44],"conventional":[33,45],"treatment":[34,46,205,240],"including":[35],"beta-blockers,":[36],"nitrates,":[37],"or":[38,87,112],"calcium":[39],"antagonists":[40],"(control":[41],"group);":[42],"234":[43],"plus":[47],"250":[49],"mg":[50],"b.i.d.":[51],"(ticlopidine":[52],"group).":[53],"The":[54,65,76,83,108,186],"predefined":[55],"end-points":[56,68],"were":[57],"vascular":[58],"death":[59,86],"and":[60,129,154,175],"acute":[61],"myocardial":[62,252],"infarction":[63],"(AMI).":[64],"incidence":[66,109],"was":[69,81,94,115,191,223],"assessed":[70],"according":[71],"intention-to-treat":[74],"principle.":[75],"post-hoc":[77,187],"estimated":[78,188],"statistical":[79,189],"power":[80,190],"80%.":[82,192],"rate":[84],"AMI":[88,114,132],"6-month":[91],"follow-up":[92],"period":[93],"reduced":[95,116],"from":[96,117,133,238],"14.9":[97],"6.8%":[99],"(-54.4%)":[100],"(odds":[101,122,138,162],"ratio:":[102,123,139,163],"0.42;":[103],"confidence":[104,125,141,165],"intervals:":[105,126,142,166],"0.22,":[106],"0.80).":[107,144],"fatal":[111],"nonfatal":[113,131],"12.2":[118],"4.3%":[120],"(-65%)":[121],"0.32;":[124],"0.14,":[127],"0.70)":[128],"10.2":[134],"3.8%":[136],"(-63%)":[137],"0.35;":[140],"0.15,":[143],"Nineteen":[145],"died;":[147],"12":[148],"control":[151,173],"group":[152,159,174,181],"(4.7%)":[153],"seven":[155],"(83%)":[160],"(-36%)":[161],"0.62;":[164],"0.21,":[167],"1.74);":[168],"five":[169],"only":[176],"one":[177],"died":[182],"an":[184],"AMI.":[185],"However,":[193],"we":[194],"cannot":[195],"draw":[196],"definitive":[197],"conclusions":[198],"about":[199],"clinical":[201],"effect":[202,250],"because":[219],"subgroup":[221],"analysis":[222],"not":[224],"planned":[225],"priori.":[227],"Nevertheless,":[228],"this":[229],"report":[230],"strongly":[231],"suggests":[232],"that":[233],"such":[234],"can":[236],"benefit":[237,244],"antiplatelet":[239],"ticlopidine;":[242],"mainly":[245],"depends":[246],"on":[247],"protective":[249],"against":[251],"infarction.":[253]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}