{"id":"https://openalex.org/W68689422","doi":null,"title":"Vaniqa--eflornithine 13.9% cream.","display_name":"Vaniqa--eflornithine 13.9% cream.","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W68689422","mag":"68689422","pmid":"https://pubmed.ncbi.nlm.nih.gov/11376395"},"language":"en","primary_location":{"id":"pmid:11376395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11376395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin therapy letter","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002475506","display_name":"Jerry Shapiro","orcid":"https://orcid.org/0000-0002-2971-1223","observed_orcids":["https://orcid.org/0000-0002-2971-1223"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Shapiro","raw_affiliation_strings":["Hair Research and Treatment Centre, and Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hair Research and Treatment Centre, and Division of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110186921","display_name":"Lui H","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Lui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3247,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.77600616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"7","first_page":"1","last_page":"3, 5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.5292999744415283,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.21639999747276306,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.04360000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/difluoromethylornithine","display_name":"difluoromethylornithine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/topical-cream","display_name":"topical cream","score":0.800000011920929},{"id":"https://openalex.org/keywords/hirsutism","display_name":"hirsutism","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ornithine-decarboxylase-inhibition","display_name":"ornithine decarboxylase inhibition","score":0.9240000247955322},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/hair-growth-inhibition","display_name":"hair growth inhibition","score":0.8069999814033508},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5950000286102295},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.699999988079071},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2780722877","wikidata":"https://www.wikidata.org/wiki/Q424751","display_name":"Eflornithine","level":4,"score":0.9469937086105347},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.7427782416343689},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5778601765632629},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.5767906308174133},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5243613719940186},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5215073227882385},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4533209502696991},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31142401695251465},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3047904968261719},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20500805974006653},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1615513265132904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.07144111394882202},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005145","descriptor_name":"Face","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006204","descriptor_name":"Hair Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11376395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11376395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Skin therapy letter","raw_type":"Journal Article"},{"id":"mag:68689422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11376395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1965109002","https://openalex.org/W1967268011","https://openalex.org/W1974953159","https://openalex.org/W1993990718","https://openalex.org/W2002669250","https://openalex.org/W2007180743","https://openalex.org/W2008554491","https://openalex.org/W2011686471","https://openalex.org/W2029077911","https://openalex.org/W2029270250","https://openalex.org/W2030580131","https://openalex.org/W2035329737","https://openalex.org/W2037851423","https://openalex.org/W2039499183","https://openalex.org/W2043411850","https://openalex.org/W2047850933","https://openalex.org/W2059110732","https://openalex.org/W2091109523","https://openalex.org/W2091457647","https://openalex.org/W2093862552","https://openalex.org/W2101693204","https://openalex.org/W2127203733","https://openalex.org/W2220905983","https://openalex.org/W2414506645","https://openalex.org/W4240426632"],"related_works":["https://openalex.org/W3188375221","https://openalex.org/W7115597636","https://openalex.org/W4298241220","https://openalex.org/W4250637148","https://openalex.org/W4234291529","https://openalex.org/W4403876952","https://openalex.org/W1611977008","https://openalex.org/W2138357005","https://openalex.org/W7095315058","https://openalex.org/W2127021539"],"abstract_inverted_index":{"Eflornithine":[0],"HCl":[1],"13.9%":[2],"cream":[3,53],"is":[4,44],"the":[5,14,18,36,55],"first":[6],"topical":[7],"prescription":[8],"treatment":[9],"to":[10,63],"be":[11],"approved":[12],"by":[13],"US":[15],"FDA":[16],"for":[17,39,46],"reduction":[19],"of":[20,57,65,73,83],"unwanted":[21,58],"facial":[22,59],"hair":[23,47,60],"in":[24,61],"women.":[25,66],"It":[26],"irreversibly":[27],"inhibits":[28],"ornithine":[29],"decarboxylase":[30],"(ODC),":[31],"an":[32],"enzyme":[33],"that":[34],"catalyzes":[35],"rate-limiting":[37],"step":[38],"follicular":[40],"polyamine":[41],"synthesis,":[42],"which":[43],"necessary":[45],"growth.":[48],"In":[49],"clinical":[50],"trials":[51],"eflornithine":[52],"slowed":[54],"growth":[56],"up":[62],"60%":[64],"Improvement":[67],"occurs":[68],"gradually":[69],"over":[70],"a":[71],"period":[72],"4-8":[74],"weeks":[75],"or":[76],"longer.":[77],"Most":[78],"reported":[79],"adverse":[80],"reactions":[81],"consisted":[82],"minor":[84],"skin":[85],"irritation.":[86]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}