{"id":"https://openalex.org/W68676002","doi":"https://doi.org/10.1182/blood.v122.21.238.238","title":"BH3 Profiling Predicts On-Target Cell Death Due To Selective Inhibition Of BCL-2 By ABT-199 In Acute Myelogenous Leukemia","display_name":"BH3 Profiling Predicts On-Target Cell Death Due To Selective Inhibition Of BCL-2 By ABT-199 In Acute Myelogenous Leukemia","publication_year":2013,"publication_date":"2013-11-15","ids":{"openalex":"https://openalex.org/W68676002","doi":"https://doi.org/10.1182/blood.v122.21.238.238","mag":"68676002"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v122.21.238.238","doi":"https://doi.org/10.1182/blood.v122.21.238.238","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.238.238","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067250104","display_name":"Leah J. Hogdal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leah Hogdal","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA,","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082924494","display_name":"Daniel J. DeAngelo","orcid":"https://orcid.org/0000-0001-7865-2306","observed_orcids":["https://orcid.org/0000-0001-7865-2306"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. DeAngelo","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071023119","display_name":"Richard Maury Stone","orcid":"https://orcid.org/0000-0002-7526-2633","observed_orcids":["https://orcid.org/0000-0002-7526-2633"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard M. Stone","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081804029","display_name":"Verena I. Gaidzik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Verena I. Gaidzik","raw_affiliation_strings":["Department of Internal Medicine, University Hospital of Ulm, Ulm, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital of Ulm, Ulm, Germany,","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108518926","display_name":"Donna M. Bucci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donna Bucci","raw_affiliation_strings":["The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA,","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053983155","display_name":"Konstanze D\u00f6hner","orcid":"https://orcid.org/0000-0002-2261-9862","observed_orcids":["https://orcid.org/0000-0002-2261-9862"]},"institutions":[{"id":"https://openalex.org/I4210155144","display_name":"University Hospital Ulm","ror":"https://ror.org/05emabm63","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155144"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Konstanze D\u00f6hner","raw_affiliation_strings":["Department of Internal Medicine, University Hospital of Ulm, Ulm, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University Hospital of Ulm, Ulm, Germany,","institution_ids":["https://openalex.org/I4210155144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060959458","display_name":"Guido Marcucci","orcid":"https://orcid.org/0000-0002-3983-5908","observed_orcids":["https://orcid.org/0000-0002-3983-5908"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guido Marcucci","raw_affiliation_strings":["Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055160574","display_name":"Jeremy\u00a0A. Ryan","orcid":"https://orcid.org/0000-0002-3327-1283","observed_orcids":["https://orcid.org/0000-0002-3327-1283"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Ryan","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022857112","display_name":"Anthony G. Letai","orcid":"https://orcid.org/0000-0002-1993-9013","observed_orcids":["https://orcid.org/0000-0002-1993-9013"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Letai","raw_affiliation_strings":["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA,","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5067250104","https://openalex.org/A5081804029","https://openalex.org/A5108518926"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2799885155","https://openalex.org/I4210155144"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.1256,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44698319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"122","issue":"21","first_page":"238","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.40630000829696655,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bcl-2-inhibition","display_name":"BCL-2 inhibition","score":0.925000011920929},{"id":"https://openalex.org/keywords/bh3-profiling","display_name":"BH3 profiling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bcl-2-dependence","display_name":"BCL-2 dependence","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.6930000185966492},{"id":"https://openalex.org/keywords/bcl-w","display_name":"Bcl-w","score":0.7509999871253967},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.45899999141693115},{"id":"https://openalex.org/keywords/drug-response-prediction","display_name":"drug response prediction","score":0.5619999766349792},{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/flt3-mutation","display_name":"FLT3 mutation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5820000171661377},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5749695897102356},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5491729378700256},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5421254634857178},{"id":"https://openalex.org/C2483381","wikidata":"https://www.wikidata.org/wiki/Q18030194","display_name":"NPM1","level":5,"score":0.5320590138435364},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48975110054016113},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.43429073691368103},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41717129945755005},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38598406314849854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3443995416164398},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3249548673629761},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2444813847541809},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.13684692978858948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v122.21.238.238","doi":"https://doi.org/10.1182/blood.v122.21.238.238","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v122.21.238.238","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2336685181","https://openalex.org/W2102461774","https://openalex.org/W7096562014","https://openalex.org/W2512593159","https://openalex.org/W2221401096","https://openalex.org/W2605114805","https://openalex.org/W2276563970","https://openalex.org/W2980245895","https://openalex.org/W2510746093","https://openalex.org/W65177702"],"abstract_inverted_index":{"Abstract":[0],"Most":[1],"patients":[2],"with":[3,94,124,231,244,329,362,385,414,538],"acute":[4],"myeloid":[5],"leukemia":[6,50],"(AML)":[7],"become":[8],"resistant":[9],"to":[10,20,26,36,38,56,59,77,85,111,145,166,180,212,270,283,332,392,436,461,465,484,488,496,500,506,553],"chemotherapy":[11],"at":[12,404,531],"some":[13],"point":[14],"in":[15,32,64,256,313,317,367,509,520,564,573],"their":[16,21],"course":[17],"and":[18,43,107,117,161,174,198,218,220,259,296,335,371,450,463],"succumb":[19],"disease.":[22],"It":[23],"is":[24,73,267,476,504],"necessary":[25],"prevent":[27,57],"chemo-resistance":[28],"or":[29,353],"enhance":[30],"chemosensitivity":[31],"a":[33,39,44,83,96,237,268,277,318,430,445,455,477,511,541,561],"selective":[34,113,468],"fashion":[35],"lead":[37],"higher":[40],"cure":[41],"rate":[42,299],"lower":[45],"toxic":[46],"burden.":[47],"The":[48,490],"B-cell":[49],"/lymphoma":[51],"2":[52,205],"(BCL-2)":[53],"protein":[54,72,327],"acts":[55],"commitment":[58],"programmed":[60],"cell":[61,105,159,172,199,257,278,315,320,369],"death":[62,200,316],"initiated":[63],"the":[65,68,101,112,154,185,191,224,272,290,298,324,386,405,408,466,524,532,556],"mitochondrion.":[66],"Inhibiting":[67],"function":[69],"of":[70,103,156,187,216,223,239,276,286,293,300,339,426,433,493,544,571],"this":[71,150],"an":[74,245,347,565],"attractive":[75],"approach":[76],"cancer":[78],"therapy,":[79],"but":[80],"it":[81],"remains":[82],"challenge":[84],"identify":[86,307],"those":[87,243],"tumors":[88],"that":[89,133,135,170,210,229,377,379,399,474,507,534],"will":[90,141,550,558],"best":[91],"be":[92,142,202,234,429,485,501,551],"treated":[93],"such":[95],"strategy.":[97],"Here,":[98],"we":[99,152,208,356,440],"test":[100,118],"sensitivity":[102,123,155,211,360,460,464,492],"AML":[104,158,240,494],"lines":[106,160,173,258,370],"primary":[108,163,175,188,225,260,372],"patient":[109,164,176,189,226,261,373],"samples":[110,165,177,262],"BCL-2":[114,125,140,366,437,502],"inhibitor,":[115],"ABT-199,":[116,497],"for":[119,236,480,513],"correlation":[120,446],"between":[121,447,458],"ABT-199":[122,181,213,232,359,393,400,409,415,419,451,462,515,529,572],"dependence":[126,252,364,449],"measured":[127,251],"by":[128,147,263,279],"BH3":[129,264,291,525,547],"profiling.":[130,265],"We":[131,168,249,375,453],"hypothesized":[132],"cells":[134,227,378,495],"are":[136,311],"more":[137,143,390],"dependent":[138,482],"on":[139,253,350,365,402],"sensitive":[144,179,391,487],"inhibition":[146],"ABT-199.":[148,167,489],"To":[149],"end,":[151],"tested":[153,357],"seven":[157],"34":[162],"found":[169,209,376],"both":[171,368],"were":[178,389],"(Figure":[182,395],"1).":[183],"In":[184],"case":[186],"cells,":[190],"median":[192],"EC-50":[193],"was":[194,214,444],"approximately":[195],"20":[196],"nM,":[197],"could":[201,233,428],"seen":[203],"within":[204],"hours.":[206],"Importantly,":[207],"independent":[215],"cytogenetics":[217],"NPM1":[219],"FLT3":[221],"mutations":[222],"suggesting":[228],"treatment":[230,394],"useful":[235],"variety":[238],"patients,":[241],"even":[242],"intrinsically":[246],"poor":[247],"prognosis.":[248],"also":[250,306],"BCL-2-mediated":[254],"apoptosis":[255],"BH3-profiling":[266,304],"method":[269],"determine":[271,554],"mitochondrial":[273,410,459,542],"priming":[274],"level":[275],"exposing":[280],"cellular":[281],"mitochondria":[282,406,483],"standardized":[284],"amounts":[285],"peptides":[287],"derived":[288],"from":[289],"domains":[292],"BH3-only":[294,326],"proteins":[295],"determining":[297],"cytochrome":[301,340,381],"c":[302,341,382],"release.":[303],"can":[305],"which":[308,498,514],"anti-apoptotic":[309,348],"species":[310],"critical":[312],"mediating":[314],"given":[319],"type.":[321],"For":[322],"instance,":[323],"BAD":[325,343,387],"binds":[328],"high":[330],"affinity":[331],"BCL-2,":[333,351],"BCL-XL":[334,352],"BCL-W.":[336,354],"Thus,":[337],"release":[338],"following":[342,383],"peptide":[344,388,469],"incubation":[345,384],"suggests":[346,473],"dependency":[349],"Therefore,":[355,439],"whether":[358],"correlates":[361,412,535],"functional":[363],"samples.":[374],"released":[380],"2).":[396],"This":[397,472],"demonstrates":[398],"functions":[401],"target":[403],"since":[407],"activity":[411,519,530],"well":[413,537],"cytotoxicity":[416],"data.":[417],"Since":[418],"does":[420],"not":[421],"inhibit":[422],"MCL-1,":[423],"increased":[424],"expression":[425],"MCL-1":[427,448,467,481],"potential":[431],"source":[432],"upfront":[434],"resistance":[435],"inhibition.":[438],"asked":[441],"if":[442,555],"there":[443,475],"sensitivity.":[452],"observed":[454,508],"weak":[456],"anti-correlation":[457],"NOXA":[470],"BH3.":[471],"minor":[478],"tendency":[479],"less":[486],"ex-vivo":[491],"appears":[499],"specific,":[503],"similar":[505],"CLL,":[510],"disease":[512],"has":[516],"demonstrated":[517],"consistent":[518],"clinical":[521,569],"trials.":[522],"Moreover,":[523],"profiling":[526,548],"studies":[527,549],"demonstrate":[528],"mitochondrion":[533],"very":[536],"cytotoxicity,":[539],"supporting":[540],"mechanism":[543],"action.":[545],"Our":[546],"undertaken":[552],"results":[557],"serve":[559],"as":[560],"predictive":[562],"biomarker":[563],"upcoming":[566],"phase":[567],"II":[568],"trial":[570],"AML.":[574],"Disclosures:":[575],"Letai:":[576],"AbbVie:":[577],"Consultancy;":[578],"Dana-Farber":[579],"Cancer":[580],"Institute:":[581],"Patents":[582],"&":[583],"Royalties.":[584]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
