{"id":"https://openalex.org/W68631806","doi":null,"title":"Interactions of verapamil and diltiazem with ketamine: effects on memory and sleeping time in mice.","display_name":"Interactions of verapamil and diltiazem with ketamine: effects on memory and sleeping time in mice.","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W68631806","mag":"68631806","pmid":"https://pubmed.ncbi.nlm.nih.gov/2087152"},"language":"en","primary_location":{"id":"pmid:2087152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2087152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028922022","display_name":"Nilanjan Saha","orcid":"https://orcid.org/0000-0003-1564-0142","observed_orcids":["https://orcid.org/0000-0003-1564-0142","https://orcid.org/0009-0001-5181-8756"]},"institutions":[{"id":"https://openalex.org/I45294948","display_name":"Post Graduate Institute of Medical Education and Research","ror":"https://ror.org/009nfym65","country_code":"IN","type":"education","lineage":["https://openalex.org/I45294948"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N Saha","raw_affiliation_strings":["Department of Pharmacology, Postgraduate Institute of Medial Education and Research, Chandigarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Postgraduate Institute of Medial Education and Research, Chandigarh, India","institution_ids":["https://openalex.org/I45294948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033548213","display_name":"Yati Chugh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Chugh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Sankaranarayanan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Sankaranarayanan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109952344","display_name":"H K Datta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Datta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.00536673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"12","issue":"7","first_page":"507","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.2734000086784363,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.01899999938905239,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.9409999847412109},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diltiazem","display_name":"diltiazem","score":1.0},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8270000219345093},{"id":"https://openalex.org/keywords/memory-consolidation","display_name":"memory consolidation","score":0.703000009059906},{"id":"https://openalex.org/keywords/memory-acquisition","display_name":"memory acquisition","score":0.8629999756813049},{"id":"https://openalex.org/keywords/memory-retrieval","display_name":"memory retrieval","score":0.9470000267028809},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sleep-duration","display_name":"sleep duration","score":0.8679999709129333},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/anesthesia","display_name":"anesthesia","score":0.5080000162124634},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C2776741139","wikidata":"https://www.wikidata.org/wiki/Q422229","display_name":"Diltiazem","level":3,"score":0.9748717546463013},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.9362407326698303},{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.8578383922576904},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5521683096885681},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.515988826751709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43599510192871094},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.1819792091846466},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16697058081626892}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004110","descriptor_name":"Diltiazem","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2087152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2087152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Journal Article"},{"id":"mag:68631806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2087152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2407805475","https://openalex.org/W2076399768","https://openalex.org/W2997862866","https://openalex.org/W2077927285","https://openalex.org/W2027203784","https://openalex.org/W2316826543","https://openalex.org/W2418370772","https://openalex.org/W2394552486","https://openalex.org/W2011860462","https://openalex.org/W2395784794"],"abstract_inverted_index":{"The":[0,98,112],"effects":[1,56,92,107],"of":[2,27,45,70,83,93,108,118,127],"ketamine":[3,94,109,128],"(3,":[4],"10":[5,48,67,78],"and":[6,10,25,43,49,54],"30":[7,50,61],"mg/kg)":[8,16,20],"alone":[9],"in":[11,34],"combination":[12],"with":[13,76,121],"verapamil":[14,66,77,122],"(10":[15],"or":[17],"diltiazem":[18,60,103],"(30":[19],"on":[21,95,110],"the":[22,41,81,91,106,125],"acquisition,":[23],"consolidation":[24,44],"retrieval":[26],"memory":[28,46],"using":[29],"a":[30],"passive":[31],"avoidance":[32],"task":[33],"mice":[35],"were":[36,57],"studied.":[37],"Ketamine":[38],"significantly":[39],"inhibited":[40],"acquisition":[42],"at":[47],"mg/kg":[51,62,79],"dose":[52,126],"levels":[53],"these":[55],"antagonized":[58],"by":[59,65],"but":[63],"not":[64,89],"mg/kg.":[68],"Studies":[69],"sleeping":[71,84,96],"time":[72],"demonstrated":[73],"that":[74,102,116],"pretreatment":[75,117],"increased":[80],"duration":[82],"time.":[85,97],"Diltiazem,":[86],"however,":[87],"did":[88],"potentiate":[90],"present":[99],"findings":[100],"indicate":[101],"can":[104],"counter":[105],"memory.":[111],"data":[113],"also":[114],"indicates":[115],"surgical":[119],"patients":[120],"may":[123],"reduce":[124],"required":[129],"for":[130],"anesthesia.":[131]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}