{"id":"https://openalex.org/W68616571","doi":null,"title":"Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia.","display_name":"Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia.","publication_year":1996,"publication_date":"1996-04-01","ids":{"openalex":"https://openalex.org/W68616571","mag":"68616571","pmid":"https://pubmed.ncbi.nlm.nih.gov/8792092"},"language":"en","primary_location":{"id":"pmid:8792092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8792092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & metabolism","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108242816","display_name":"Elazar Shafrir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"E Shafrir","raw_affiliation_strings":["Department of Biochemistry, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108242816"],"corresponding_institution_ids":["https://openalex.org/I2799899409"],"apc_list":null,"apc_paid":null,"fwci":2.9042,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.90272218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"122","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/diabesity","display_name":"diabesity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/compensatory-insulin-secretion","display_name":"compensatory insulin secretion","score":0.6740000247955322},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/insulin-receptor-tyrosine-kinase","display_name":"insulin receptor tyrosine kinase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5920000076293945},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.8289999961853027},{"id":"https://openalex.org/keywords/psammomys-obesus","display_name":"Psammomys obesus","score":0.9739999771118164},{"id":"https://openalex.org/keywords/desert-gerbil","display_name":"desert gerbil","score":0.7630000114440918},{"id":"https://openalex.org/keywords/acomys-cahirinus","display_name":"Acomys cahirinus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/thrifty-gene-hypothesis","display_name":"thrifty gene hypothesis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.5379999876022339},{"id":"https://openalex.org/keywords/insulin-deficiency","display_name":"insulin deficiency","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8516608476638794},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.822782039642334},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8140945434570312},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.6685003638267517},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.662750244140625},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.6464484333992004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5785779356956482},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5345823764801025},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.4976847469806671},{"id":"https://openalex.org/C2777368190","wikidata":"https://www.wikidata.org/wiki/Q477390","display_name":"Hyperinsulinism","level":4,"score":0.4928619861602783},{"id":"https://openalex.org/C2780609358","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Impaired glucose tolerance","level":4,"score":0.426201730966568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2884410619735718},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.05831795930862427}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005849","descriptor_name":"Gerbillinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008017","descriptor_name":"Life Expectancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009115","descriptor_name":"Muridae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011922","descriptor_name":"Rats, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8792092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8792092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & metabolism","raw_type":"Journal Article"},{"id":"mag:68616571","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8792092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2274527500","https://openalex.org/W2161567465","https://openalex.org/W1982946550","https://openalex.org/W2003693236","https://openalex.org/W2166224820","https://openalex.org/W2063007317","https://openalex.org/W3083878863","https://openalex.org/W7010190871","https://openalex.org/W2027009452","https://openalex.org/W124070935"],"abstract_inverted_index":{"Studies":[0],"involving":[1],"genetically":[2],"and":[3,26,84,113,172,193,222,231,247],"nutritionally":[4],"induced":[5],"diabetes":[6,249],"in":[7,37,116,202,220,223,235,243,252],"animals":[8],"indicate":[9],"that":[10,261],"early":[11],"hyperinsulinaemia":[12],"is":[13,126,147,165,188,200,259,265,273],"the":[14,65,78,137,175,232,262,274],"causative":[15],"factor":[16],"of":[17,53,77,139,158,217,278],"tissue":[18],"insulin":[19,24,111,115,140],"resistance,":[20],"leading":[21],"to":[22,69,88,141,167,181,213,228],"compensatory":[23],"oversecretion":[25,67],"pancreatic":[27],"beta-cell":[28,226],"dysfunction.":[29],"The":[30,95,184,225],"models":[31],"for":[32,239],"this":[33],"syndrome,":[34],"which":[35,62,103,119,178],"occurs":[36],"association":[38],"with":[39,48,58,150,206],"obesity":[40],"(thus":[41],"termed":[42],"\"diabesity\"":[43],"here),":[44],"concern":[45],"either":[46],"species":[47,205],"a":[49,133,155,215,240],"sturdy":[50],"pancreas,":[51],"capable":[52],"long-lasting":[54,229],"oversecretion,":[55],"or":[56,74],"those":[57],"labile":[59],"beta":[60,117],"cells":[61,118],"cannot":[63],"sustain":[64],"initial":[66],"due":[68],"genomic":[70],"modifiers":[71],"enhancing":[72],"gluco-":[73],"lipotoxicity.":[75],"Examples":[76],"latter":[79,96],"are":[80,109,179],"db/db":[81],"mice":[82,100],"mutants":[83],"desert":[85],"gerbils":[86],"susceptible":[87],"overnutrition,":[89],"i.e.":[90],"Psammomys":[91],"obesus":[92,125],"(sand":[93],"rats).":[94],"also":[97,210],"comprise":[98],"spiny":[99],"(Acomys":[101],"cahirinus)":[102],"do":[104],"not":[105],"manifest":[106],"resistance.":[107],"They":[108],"low":[110,129],"secretors":[112],"accumulate":[114],"may":[120],"disintegrate,":[121],"producing":[122],"insulin-deficiency.":[123],"P.":[124],"characterised":[127],"by":[128,190],"insulin-receptor":[130],"density.":[131],"On":[132],"high":[134],"energy":[135],"diet,":[136],"capacity":[138],"activate":[142],"receptor":[143,176,197,233,268],"tyrosine":[144],"kinase":[145],"(TK)":[146],"reduced,":[148],"concomitant":[149],"hyperinsulinaemia.":[151,280],"With":[152],"subsequent":[153],"hyperglycaemia,":[154],"vicious":[156],"circle":[157],"insulinaemia-glycaemia":[159],"accentuates":[160],"TK":[161,182,186,198],"activation":[162,187],"failure.":[163],"This":[164],"attributable":[166],"multisite":[168],"phosphorylation,":[169],"including":[170],"serine":[171],"threonine":[173],"on":[174,267],"b-subunit,":[177],"inhibitory":[180],"activity.":[183],"compromised":[185],"reversible":[189],"diet":[191],"restriction":[192],"normoinsulinaemia":[194],"restoration.":[195],"Similar":[196],"malfunction":[199,234],"seen":[201],"other":[203],"animal":[204],"diabesity.":[207],"Hyperinsulinaemia":[208],"has":[209],"been":[211],"shown":[212],"cause":[214],"variety":[216],"detrimental":[218],"effects":[219],"vitro":[221],"vivo.":[224],"response":[227],"stimulation":[230],"diabesity":[236],"have":[237],"implications":[238],"similar":[241],"etiology":[242],"human":[244],"insulin-resistance":[245],"syndrome":[246],"non-insulin-dependent":[248],"mellitus,":[250],"particularly":[251],"populations":[253],"emerging":[254],"into":[255],"nutritional":[256],"abundance.":[257],"It":[258],"postulated":[260],"\"thrifty":[263],"gene\"":[264],"focused":[266],"TK,":[269],"whose":[270],"reduced":[271],"function":[272],"primary":[275],"phenotypic":[276],"expression":[277],"protracted":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
