{"id":"https://openalex.org/W68613483","doi":null,"title":"Detection of neopterin as parameter of potential monocyte activation in patients with acute ischemic stroke.","display_name":"Detection of neopterin as parameter of potential monocyte activation in patients with acute ischemic stroke.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W68613483","mag":"68613483","pmid":"https://pubmed.ncbi.nlm.nih.gov/18767412"},"language":"en","primary_location":{"id":"pmid:18767412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18767412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of internal medicine = Revue roumaine de medecine interne","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108493034","display_name":"Inimioara Mihaela Cojocaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]},{"id":"https://openalex.org/I4210153981","display_name":"Spitalul Clinic Colentina","ror":"https://ror.org/04fkbqt11","country_code":"RO","type":"healthcare","lineage":["https://openalex.org/I4210153981"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Inimioara Mihaela Cojocaru","raw_affiliation_strings":["\"Carol Davila\" University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania. mcojocar@cmb.ro"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\"Carol Davila\" University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania. mcojocar@cmb.ro","institution_ids":["https://openalex.org/I162051807","https://openalex.org/I4210153981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041643386","display_name":"Manole Cojocaru","orcid":"https://orcid.org/0000-0002-7192-7490","observed_orcids":["https://orcid.org/0000-0002-7192-7490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cojocaru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059092152","display_name":"C\u00e9cilia Burcin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Burcin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032360381","display_name":"Adina Nicoleta Atanasiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adina Atanasiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2207,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58267563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"45","issue":"4","first_page":"365","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.6865000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.23829999566078186,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neopterin","display_name":"neopterin","score":1.0},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.9309999942779541},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2776603314","wikidata":"https://www.wikidata.org/wiki/Q908292","display_name":"Neopterin","level":2,"score":0.9890827536582947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9236161112785339},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6299440264701843},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6100807785987854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6034786701202393},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.5502864122390747},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5297651886940002},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.497268944978714},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.4336961507797241},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.43314510583877563},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4107632040977478},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39576709270477295},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36751943826675415},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.3591915965080261},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019798","descriptor_name":"Neopterin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:18767412","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18767412","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of internal medicine = Revue roumaine de medecine interne","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093965598","https://openalex.org/W2078119036","https://openalex.org/W874507397","https://openalex.org/W4288611117","https://openalex.org/W3188214419","https://openalex.org/W2018754047","https://openalex.org/W2402008847","https://openalex.org/W2946083600","https://openalex.org/W2079534129","https://openalex.org/W2736739805"],"abstract_inverted_index":{"The":[0,127],"mechanisms":[1,121],"by":[2,197],"which":[3,135],"inflammation":[4],"may":[5,155],"induce":[6],"endothelial":[7],"dysfunction":[8],"are":[9],"not":[10],"fully":[11],"understood.":[12],"It":[13],"was":[14,76,183],"analyzed":[15],"if":[16],"neopterin":[17,82,102,182],"(a":[18],"by-product":[19],"of":[20,35,63,80,101,129,133,142,159,185],"activated":[21],"macrophage":[22],"metabolism)":[23],"is":[24,136],"elevated":[25],"in":[26],"patients":[27,43,65,151,174],"with":[28,44,66,92,152,175],"systemic":[29],"inflammatory":[30,145,160],"insult":[31],"at":[32],"the":[33,143,148],"time":[34],"ischemic":[36,58,74,94,125,153,171],"stroke.":[37,59,172],"There":[38],"were":[39,52,84],"investigated":[40],"86":[41],"consecutive":[42],"mean":[45,67],"age":[46,68],"67":[47],"+/-":[48,70,105,110,114],"7.8":[49],"years":[50,72],"who":[51],"admitted":[53],"within":[54],"24":[55],"h":[56],"after":[57,170],"A":[60],"control":[61],"group":[62],"37":[64],"58":[69],"4.9":[71],"without":[73],"stroke":[75,95,154,176],"also":[77],"tested.":[78],"Measurements":[79],"serum":[81,99,131],"levels":[83,100,132,158],"performed":[85],"using":[86],"enzyme":[87],"linked":[88],"immunosorbent":[89],"assay.":[90],"Patients":[91],"acute":[93],"had":[96],"significantly":[97],"higher":[98,130,157],"(mean":[103],"value":[104],"SD)":[106],"than":[107],"controls:":[108],"9.6":[109],"1.2":[111],"vs.":[112],"7":[113],"0.8":[115],"nmol/L":[116],"(p":[117],"<":[118],"0.01).":[119],"Immune":[120],"contribute":[122],"to":[123,194],"cerebral":[124],"injury.":[126],"finding":[128],"neopterin,":[134],"regarded":[137],"as":[138],"a":[139],"humoral":[140],"component":[141],"immune-mediated":[144],"response,":[146],"sustains":[147],"hypothesis":[149],"that":[150,181],"show":[156],"markers":[161],"like":[162],"neopterin.":[163],"Our":[164],"results":[165,192],"indicate":[166],"increased":[167],"monocyte":[168],"activation":[169],"In":[173],"it":[177],"has":[178],"been":[179],"shown":[180],"determinant":[184],"endothelium-dependent":[186],"vascular":[187],"dysfunction.":[188],"However,":[189],"these":[190],"preliminary":[191],"need":[193],"be":[195],"confirmed":[196],"controlled":[198],"studies.":[199]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
